Latest PhD Studentships - 1 December 2009

Welcome to the FindAPhD weekly Newsletter. Listed below are the latest research projects to be advertised on FindAPhD.com.

University of Leeds
Understanding and influencing the ecology of staphylococci on human skin

University of St Andrews
Development of Homogeneous Catalysts – Green Chemistry and Pharmaceutical Compounds.

University of Strathclyde
Extraction, purification and characterisation of antimicrobial natural products from traditional herbal remedies

University of Strathclyde
Characterisation of the effect of antibacterial agents on Streptomyces coelicolor growth and development

University of Leeds
Targeting and functional regulation of an intracellular P2X receptor

King's College London
Contribution of stem cell dysfunction to disease progression in muscular dystrophy

King's College London
How are signaling networks central to development, redeployed to regulate adult muscle stem cell function?

King's College London
The potential of human spinal cord stem cells to counteract astrocyte-induced neurotoxicity in ALS

King's College London
Influence of nutrition on adult neural stem cells and mental health

King's College London
Cell fate decisions in sensory stem cells: a systems biology approach

King's College London
Directed stem cell migration and tissue repair

Queen's University Belfast
Matching nitrogen application to crop demand in winter wheat to optimize nitrogen use efficiency

King's College London
Integration of embryonic stem cell-derived motor neurons into neural circuits

King's College London
Using mesenchymal stem cells to improve survival of transplanted islets in diabetes therapy

Heriot-Watt University
Advanced waveguide laser source development

Many more projects have been added this week! Click here to view them all!

Kind regards,

The FindAPhD.com Team

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Mol. Biol. Cell Table of Contents for 1 December 2009; Vol. 20, No. 23

		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

Mol. Biol. Cell Online Table of Contents Alert

A new issue of Molecular Biology of the Cell is available online:

1 December 2009; Vol. 20, No. 23

The below Table of Contents is available online at: http://www.molbiolcell.org/content/vol20/issue23/?etoc

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Articles

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Caspase-independent Mitochondrial Cell Death Results from Loss of Respiration, Not Cytotoxic Protein Release

Lydia Lartigue, Yulia Kushnareva, Youngmo Seong, Helen Lin, Benjamin Faustin, and Donald D. Newmeyer

Polyamines Regulate c-Myc Translation through Chk2-dependent HuR Phosphorylation

Lan Liu, Jaladanki N. Rao, Tongtong Zou, Lan Xiao, Peng-Yuan Wang, Douglas J. Turner, Myriam Gorospe, and Jian-Ying Wang

Brd4 Marks Select Genes on Mitotic Chromatin and Directs Postmitotic Transcription

Anup Dey, Akira Nishiyama, Tatiana Karpova, James McNally, and Keiko Ozato

Evidence that Electrostatic Interactions between Vesicle-associated Membrane Protein 2 and Acidic Phospholipids May Modulate the Fusion of Transport Vesicles with the Plasma Membrane

Dumaine Williams, Jérome Vicôgne, Irina Zaitseva, Stuart McLaughlin, and Jeffrey E. Pessin

Neogenin Regulates Skeletal Myofiber Size and Focal Adhesion Kinase and Extracellular Signal-regulated Kinase Activities In Vivo and In Vitro

Gyu-Un Bae, Youn-Joo Yang, Guoying Jiang, Mingi Hong, Hye-Jin Lee, Marc Tessier-Lavigne, Jong-Sun Kang, and Robert S. Krauss

Macrophages Create an Acidic Extracellular Hydrolytic Compartment to Digest Aggregated Lipoproteins

Abigail S. Haka, Inna Grosheva, Ethan Chiang, Adina R. Buxbaum, Barbara A. Baird, Lynda M. Pierini, and Frederick R. Maxfield

RhoG Promotes Neural Progenitor Cell Proliferation in Mouse Cerebral Cortex

Satoshi Fujimoto, Manabu Negishi, and Hironori Katoh

Dcp1-Bodies in Mouse Oocytes

Adam Swetloff, Beatrice Conne, Joachim Huarte, Jean-Luc Pitetti, Serge Nef, and Jean-Dominique Vassalli

Rescue of Munc18-1 and -2 Double Knockdown Reveals the Essential Functions of Interaction between Munc18 and Closed Syntaxin in PC12 Cells

Liping Han, Tiandan Jiang, Gayoung A. Han, Nancy T. Malintan, Li Xie, Li Wang, Frederick W. Tse, Herbert Y. Gaisano, Brett M. Collins, Frederic A. Meunier, and Shuzo Sugita

Heat-Shock Factor 1 Controls Genome-wide Acetylation in Heat-shocked Cells

Sabrina Fritah, Edwige Col, Cyril Boyault, Jérôme Govin, Karin Sadoul, Susanna Chiocca, Elisabeth Christians, Saadi Khochbin, Caroline Jolly, and Claire Vourc'h

The Exomer Coat Complex Transports Fus1p to the Plasma Membrane via a Novel Plasma Membrane Sorting Signal in Yeast

Robyn M. Barfield, J. Christopher Fromme, and Randy Schekman

Tight Functional Coupling of Kinesin-1A and Dynein Motors in the Bidirectional Transport of Neurofilaments

Atsuko Uchida, Nael H. Alami, and Anthony Brown

Utp9p Facilitates Msn5p-mediated Nuclear Reexport of Retrograded tRNAs in Saccharomyces cerevisiae

Manoja B.K. Eswara, Andrew T. McGuire, Jacqueline B. Pierce, and Dev Mangroo

A Mutation Associated with CMT2A Neuropathy Causes Defects in Fzo1 GTP Hydrolysis, Ubiquitylation, and Protein Turnover

Elizabeth A. Amiott, Mickael M. Cohen, Yann Saint-Georges, Allan M. Weissman, and Janet M. Shaw

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Corrections

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Rack-1 Directs Dynactin-dependent RAB-11 Endosomal Recycling during Mitosis in Caenorhabditis eleganshttp://www.molbiolcell.org/cgi/content/full/20/23/5036

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Kidney International - Table of Contents alert Volume 76 Supplement 114s

KIDNEY INTERNATIONAL

December 2009 Volume 76 Number S114, pp S1 - S42

International Society of Nephrology
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----------------------
INTRODUCTION
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Beyond phosphate binding: the effect of binder therapy on novel biomarkers may have clinical implications for the management of chronic kidney disease patients
Gary E Striker
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----------------------
REVIEWS
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Role of oxidants/inflammation in declining renal function in chronic kidney disease and normal aging
Helen Vlassara, Massimo Torreggiani, James B Post, Feng Zheng, Jaime Uribarri and Gary E Striker
Abstract: http://links.ealert.nature.com/ctt?kn=7&m=34450984&r=MTc2MzAwNDQzNwS2&b=2&j=NjE2Njk0MTQS1&mt=1&rt=0
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Uremic toxins originating from colonic microbial metabolism
Pieter Evenepoel, Bjorn K I Meijers, Bert R M Bammens and Kristin Verbeke
Abstract: http://links.ealert.nature.com/ctt?kn=44&m=34450984&r=MTc2MzAwNDQzNwS2&b=2&j=NjE2Njk0MTQS1&mt=1&rt=0
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Endotoxin-binding affinity of sevelamer: a potential novel anti-inflammatory mechanism
Phyllis P Sun, Mary C Perianayagam and Bertrand L Jaber
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Sevelamer and the bone-vascular axis in chronic kidney disease: bone turnover, inflammation, and calcification regulation
Vincent M Brandenburg, Willi Jahnen-Dechent and Markus Ketteler
Abstract: http://links.ealert.nature.com/ctt?kn=36&m=34450984&r=MTc2MzAwNDQzNwS2&b=2&j=NjE2Njk0MTQS1&mt=1&rt=0
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Clinical relevance of FGF-23 in chronic kidney disease
Sarah Seiler, Gunnar H Heine and Danilo Fliser
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Nature Reviews Gastroenterology & Hepatology - Table of Contents alert Volume 6 Issue 12

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY

December 2009 Volume 6 Number 12

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----------------------
EDITORIAL
----------------------
Indecent exposures
Stephen B. Hanauer
p685 | doi:10.1038/nrgastro.2009.204
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----------------------
RESEARCH HIGHLIGHTS
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Pediatrics: Amitriptyline and placebo in children with functional
gastrointestinal disorders
p687 | doi:10.1038/nrgastro.2009.190
http://links.ealert.nature.com/ctt?kn=47&m=34450818&r=MTc2OTYyOTQ2MwS2&b=2&j=NjE2NjgxNzUS1&mt=1&rt=0

Colonoscopy: Unsedated colonoscopy is a feasible primary screening tool for
colorectal cancer
p688 | doi:10.1038/nrgastro.2009.188
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Cancer: Human bacterium induces colon tumors in mice through activation of
TH17 cells
p688 | doi:10.1038/nrgastro.2009.189
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Targeting Ras in HCC
p689 | doi:10.1038/nrgastro.2009.191
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IBD: Sargramostim for corticosteroid-dependent Crohn's disease
p689 | doi:10.1038/nrgastro.2009.192
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Ulcerative proctitis: Potential therapeutic role for appendicectomy
p689 | doi:10.1038/nrgastro.2009.194
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Liver transplantation: Predicting infectious complications after OLT
p690 | doi:10.1038/nrgastro.2009.187
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Fecal incontinence: Efficacy of biofeedback
p690 | doi:10.1038/nrgastro.2009.193
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----------------------
NEWS AND VIEWS
----------------------
Primary sclerosing cholangitis: The importance of treating stenoses and
infections
Jens J. W. Tischendorf and Ramin Schirin-Sokhan
p691 | doi:10.1038/nrgastro.2009.181
The treatment of primary sclerosing cholangitis is a major challenge.
Complications such as dominant bile duct stenoses and biliary infections
are associated with poor outcomes. Data from a new prospective study with
a follow-up of 20 years now show that dominant stenosis and fungal, but
not bacterial infections reduce survival free of liver transplantation.
http://links.ealert.nature.com/ctt?kn=8&m=34450818&r=MTc2OTYyOTQ2MwS2&b=2&j=NjE2NjgxNzUS1&mt=1&rt=0

Gastrointestinal bleeding: Carvedilol-the best [beta]-blocker for
primary prophylaxis?
Emmanuel A. Tsochatzis, Christos K. Triantos and Andrew K. Burroughs
p692 | doi:10.1038/nrgastro.2009.198
Endoscopic band ligation (EBL) and nonselective [beta]-blockade are two
effective strategies in the primary prevention of variceal bleeding.
Meta-analyses have shown an advantage of EBL over propranolol with regard
to bleeding rates but not mortality. By contrast, a recent randomized,
controlled trial shows less bleeding associated with the use of carvedilol
compared with EBL.
http://links.ealert.nature.com/ctt?kn=7&m=34450818&r=MTc2OTYyOTQ2MwS2&b=2&j=NjE2NjgxNzUS1&mt=1&rt=0

Chronic anal fissure: Surgical or reversible neurochemical sphincterotomy?
Giuseppe Brisinda and Serafino Vanella
p694 | doi:10.1038/nrgastro.2009.200
The management of chronic anal fissure has received renewed interest and
has been re-evaluated over the past 20 years. The use of botulinum toxin
seems to be a promising and safe approach, particularly in patients at
high risk for incontinence. A recent meta-analysis investigated the efficacy
of botulinum toxin injection compared with lateral internal sphincterotomy
for the management of this condition.
http://links.ealert.nature.com/ctt?kn=10&m=34450818&r=MTc2OTYyOTQ2MwS2&b=2&j=NjE2NjgxNzUS1&mt=1&rt=0

GERD: Is laparoscopic surgery cost-effective?
Alexander C. Ford
p695 | doi:10.1038/nrgastro.2009.196
A Markov model using data from a randomized, controlled trial has
demonstrated that laparoscopic fundoplication is a cost-effective
intervention for the management of chronic GERD. However, there are some
limitations of the model, discussed below, which suggest that the results
should be viewed cautiously until longer follow-up is reported.
http://links.ealert.nature.com/ctt?kn=9&m=34450818&r=MTc2OTYyOTQ2MwS2&b=2&j=NjE2NjgxNzUS1&mt=1&rt=0

Hepatocellular adenoma: Should phenotypic classification direct management?
Turkan Terkivatan and Jan N. M. Ijzermans
p697 | doi:10.1038/nrgastro.2009.199
The Bordeaux group has made major progress in the genotyping and phenotyping
of hepatocellular adenomas. Their efforts have allowed the classification
of hepatocellular adenomas into subtypes, which enhances our understanding
of this benign liver lesion. The clinical relevance of their findings is
open to debate.
http://links.ealert.nature.com/ctt?kn=4&m=34450818&r=MTc2OTYyOTQ2MwS2&b=2&j=NjE2NjgxNzUS1&mt=1&rt=0

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REVIEWS
----------------------
Epidemiology of pancreatic cancer: an overview
Sara Raimondi, Patrick Maisonneuve and Albert B. Lowenfels
Published online: 06 October 2009
p699 | doi:10.1038/nrgastro.2009.177
Pancreatic cancer, although infrequent, has an extremely high mortality
rate. The epidemiologic features of this rare cancer are still poorly known.
In this Review Raimondi and colleagues discuss the environmental, lifestyle
and genetic factors that increase or decrease the probability of developing
pancreatic cancer and that may explain the different incidence rates observed
in distinct subpopulations.
Abstract: http://links.ealert.nature.com/ctt?kn=3&m=34450818&r=MTc2OTYyOTQ2MwS2&b=2&j=NjE2NjgxNzUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=6&m=34450818&r=MTc2OTYyOTQ2MwS2&b=2&j=NjE2NjgxNzUS1&mt=1&rt=0

Anastomoses of the lower gastrointestinal tract
Govind Nandakumar, Sharon L. Stein and Fabrizio Michelassi
Published online: 03 November 2009
p709 | doi:10.1038/nrgastro.2009.185
Intestinal anastomoses are frequently performed to remove tumors or diseased
tissue. They have clear benefits but they can also lead to serious
complications such as dehiscences and strictures. This Review discusses
the surgical techniques, healing factors and perioperative and postoperative
strategies to minimize complications when performing anastomoses of the lower
gastrointestinal tract.
Abstract: http://links.ealert.nature.com/ctt?kn=27&m=34450818&r=MTc2OTYyOTQ2MwS2&b=2&j=NjE2NjgxNzUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=26&m=34450818&r=MTc2OTYyOTQ2MwS2&b=2&j=NjE2NjgxNzUS1&mt=1&rt=0

Endoscopy for upper gastrointestinal bleeding: is routine second-look
necessary?
Kelvin K. F. Tsoi, Philip W. Y. Chiu and Joseph J. Y. Sung
p717 | doi:10.1038/nrgastro.2009.186
A repeat endoscopic evaluation of a bleeding lesion on subsequent follow-up
is commonly called second-look endoscopy. Tsoi and colleagues review the
findings from five randomized, controlled trials and consider whether
second-look endoscopy can be recommended as routine practice, and which
groups of patients might benefit most. The cost-effectiveness of second-look
endoscopy and the use of PPIs versus second-look endoscopy are also discussed.
Abstract: http://links.ealert.nature.com/ctt?kn=25&m=34450818&r=MTc2OTYyOTQ2MwS2&b=2&j=NjE2NjgxNzUS1&mt=1&rt=0
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Stem cells in gastroenterology and hepatology
Michael Quante and Timothy C. Wang
Published online: 03 November 2009
p724 | doi:10.1038/nrgastro.2009.195
Stem cells are primitive, relatively unspecialized cells that can self-renew
and are multipotent. In this Review, Quante and Wang discuss potential
types of stem cells found within the gastrointestinal tract, the
susceptibility of these stem cells for malignant transformation, and their
potential for use in restoring tissue function to treat gastrointestinal
disorders.
Abstract: http://links.ealert.nature.com/ctt?kn=23&m=34450818&r=MTc2OTYyOTQ2MwS2&b=2&j=NjE2NjgxNzUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=22&m=34450818&r=MTc2OTYyOTQ2MwS2&b=2&j=NjE2NjgxNzUS1&mt=1&rt=0

----------------------
PERSPECTIVES
----------------------
OPINION
CT and radiation-related cancer risk-time for a paradigm shift?
David A. Johnson, Paul R. Helft and Douglas K. Rex
p738 | doi:10.1038/nrgastro.2009.184
The use of CT has been increasing exponentially over the past decade.
Unfortunately, there is little cognizance among health-care providers
(or their patients) about the relative latent cancer risks associated with
repetitive exposure to ionizing radiation. Given the exposure of a relatively
high proportion of the population to these tests, it is incumbent on
health-care providers to have an improved understanding of these risks and
discuss them accordingly with their patients.
Abstract: http://links.ealert.nature.com/ctt?kn=21&m=34450818&r=MTc2OTYyOTQ2MwS2&b=2&j=NjE2NjgxNzUS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=19&m=34450818&r=MTc2OTYyOTQ2MwS2&b=2&j=NjE2NjgxNzUS1&mt=1&rt=0

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Kidney International - Table of Contents alert Volume 76 Issue 12

KIDNEY INTERNATIONAL

December 2009 Volume 76 Number 12, pp 1213 - 1297

International Society of Nephrology
===================================
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Renew your ISN membership now!
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----------------------

----------------------
IN THIS ISSUE
----------------------
In this Issue
http://links.ealert.nature.com/ctt?kn=45&m=34450634&r=MTc2MzAwNDQzNwS2&b=2&j=NjE2NjY4MjcS1&mt=1&rt=0

----------------------
BOOK REVIEW
----------------------
Proteomics in Nephrology: Towards Clinical Applications
Gang Jee Ko and Hamid Rabb
http://links.ealert.nature.com/ctt?kn=52&m=34450634&r=MTc2MzAwNDQzNwS2&b=2&j=NjE2NjY4MjcS1&mt=1&rt=0

----------------------
JOURNAL CLUB
----------------------
Journal Club
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----------------------
COMMENTARIES
----------------------
Vitamin D: a new hope for chronic kidney disease?
Min Li and Vecihi Batuman
Abstract: http://links.ealert.nature.com/ctt?kn=59&m=34450634&r=MTc2MzAwNDQzNwS2&b=2&j=NjE2NjY4MjcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=48&m=34450634&r=MTc2MzAwNDQzNwS2&b=2&j=NjE2NjY4MjcS1&mt=1&rt=0

Expanding the spectrum of NPHS1-associated disease
Martin R Pollak
Abstract: http://links.ealert.nature.com/ctt?kn=49&m=34450634&r=MTc2MzAwNDQzNwS2&b=2&j=NjE2NjY4MjcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=50&m=34450634&r=MTc2MzAwNDQzNwS2&b=2&j=NjE2NjY4MjcS1&mt=1&rt=0

Protein kinase C[zeta]: not-so-innocent bystander or unusual suspect in kidney transplant rejection?
Jens WD Goebel
Abstract: http://links.ealert.nature.com/ctt?kn=18&m=34450634&r=MTc2MzAwNDQzNwS2&b=2&j=NjE2NjY4MjcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=17&m=34450634&r=MTc2MzAwNDQzNwS2&b=2&j=NjE2NjY4MjcS1&mt=1&rt=0

----------------------
REVIEWS
----------------------
The enigmatic parietal epithelial cell is finally getting noticed: a review
Takamoto Ohse, Jeffrey W Pippin, Alice M Chang, Ronald D Krofft, Jeffrey H Miner, Michael R Vaughan and Stuart J Shankland
Abstract: http://links.ealert.nature.com/ctt?kn=15&m=34450634&r=MTc2MzAwNDQzNwS2&b=2&j=NjE2NjY4MjcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=14&m=34450634&r=MTc2MzAwNDQzNwS2&b=2&j=NjE2NjY4MjcS1&mt=1&rt=0

Assessing acid-base disorders
Horacio J Adrogue, F John Gennari, John H Galla and Nicolaos E Madias
Abstract: http://links.ealert.nature.com/ctt?kn=13&m=34450634&r=MTc2MzAwNDQzNwS2&b=2&j=NjE2NjY4MjcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=11&m=34450634&r=MTc2MzAwNDQzNwS2&b=2&j=NjE2NjY4MjcS1&mt=1&rt=0

----------------------
ORIGINAL ARTICLES
----------------------
Combination therapy with paricalcitol and trandolapril reduces renal fibrosis in obstructive nephropathy
Xiaoyue Tan, Weichun He and Youhua Liu
Abstract: http://links.ealert.nature.com/ctt?kn=84&m=34450634&r=MTc2MzAwNDQzNwS2&b=2&j=NjE2NjY4MjcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=82&m=34450634&r=MTc2MzAwNDQzNwS2&b=2&j=NjE2NjY4MjcS1&mt=1&rt=0

Localization of the succinate receptor in the distal nephron and its signaling in polarized MDCK cells
Joris H Robben, Robert A Fenton, Sarah L Vargas, Horst Schweer, Janos Peti-Peterdi, Peter M T Deen and Graeme Milligan
Abstract: http://links.ealert.nature.com/ctt?kn=86&m=34450634&r=MTc2MzAwNDQzNwS2&b=2&j=NjE2NjY4MjcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=85&m=34450634&r=MTc2MzAwNDQzNwS2&b=2&j=NjE2NjY4MjcS1&mt=1&rt=0

Nephrin mutations cause childhood- and adult-onset focal segmental glomerulosclerosis
Sheila Santin, Rafael Garcia-Maset, Patricia Ruiz, Isabel Gimenez, Isabel Zamora, Antonia Pena, Alvaro Madrid, Juan A Camacho, Gloria Fraga, Ana Sanchez-Moreno, Maria Angeles Cobo, Carmen Bernis, Alberto Ortiz, Augusto Luque de Pablos, Guillem Pintos, Maria Luisa Justa, Emilia Hidalgo-Barquero, Patricia Fernandez-Llama, Jose Ballarin, Elisabet Ars and Roser Torra on behalf of the FSGS Spanish Study Group
Abstract: http://links.ealert.nature.com/ctt?kn=72&m=34450634&r=MTc2MzAwNDQzNwS2&b=2&j=NjE2NjY4MjcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=75&m=34450634&r=MTc2MzAwNDQzNwS2&b=2&j=NjE2NjY4MjcS1&mt=1&rt=0

Protein microarrays identify antibodies to protein kinase C[zeta] that are associated with a greater risk of allograft loss in pediatric renal transplant recipients
Scott M Sutherland, Li Li, Tara K Sigdel, Persis P Wadia, David B Miklos, Atul J Butte and Minnie M Sarwal
Abstract: http://links.ealert.nature.com/ctt?kn=76&m=34450634&r=MTc2MzAwNDQzNwS2&b=2&j=NjE2NjY4MjcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=77&m=34450634&r=MTc2MzAwNDQzNwS2&b=2&j=NjE2NjY4MjcS1&mt=1&rt=0

A prospective study of protein excretion using short-interval timed urine collections in patients with lupus nephritis
Derek M Fine, Martina Ziegenbein, Michelle Petri, Ernest C Han, Alison M McKinley, Jerry W Chellini, Haikady N Nagaraja, Kathryn A Carson and Brad H Rovin
Abstract: http://links.ealert.nature.com/ctt?kn=78&m=34450634&r=MTc2MzAwNDQzNwS2&b=2&j=NjE2NjY4MjcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=79&m=34450634&r=MTc2MzAwNDQzNwS2&b=2&j=NjE2NjY4MjcS1&mt=1&rt=0

----------------------
TECHNICAL NOTE
----------------------
The use of continuous renal replacement therapy in series with extracorporeal membrane oxygenation
Maria J Santiago, Amelia Sanchez, Jesus Lopez-Herce, Rosario Perez, Jimena del Castillo, Javier Urbano and Angel Carrillo
Abstract: http://links.ealert.nature.com/ctt?kn=81&m=34450634&r=MTc2MzAwNDQzNwS2&b=2&j=NjE2NjY4MjcS1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=104&m=34450634&r=MTc2MzAwNDQzNwS2&b=2&j=NjE2NjY4MjcS1&mt=1&rt=0

----------------------
LETTERS TO THE EDITOR
----------------------
Inhibiting renal sodium-glucose transport in diabetes: pass the salt
Robert Zietse and Ewout J Hoorn
http://links.ealert.nature.com/ctt?kn=101&m=34450634&r=MTc2MzAwNDQzNwS2&b=2&j=NjE2NjY4MjcS1&mt=1&rt=0

Response to `Inhibiting renal sodium-glucose transport in diabetes: pass the salt'
George L Bakris and Vivian A Fonseca
http://links.ealert.nature.com/ctt?kn=95&m=34450634&r=MTc2MzAwNDQzNwS2&b=2&j=NjE2NjY4MjcS1&mt=1&rt=0

----------------------
MAKE YOUR DIAGNOSIS
----------------------
The Case | A Caucasian male with dark skin, black urine, and acute kidney injury
Arvin L Santos, Ghassan Ibrahim, Sharon Mount, Christian Thomas and Wolfgang J Weise
http://links.ealert.nature.com/ctt?kn=93&m=34450634&r=MTc2MzAwNDQzNwS2&b=2&j=NjE2NjY4MjcS1&mt=1&rt=0

----------------------
NEPHROLOGY IMAGE
----------------------
Hydronephrosis in autosomal dominant polycystic kidney disease
Andreas D Kistler, Diane Poster, Rudolf P Wuthrich and Andreas L Serra
http://links.ealert.nature.com/ctt?kn=100&m=34450634&r=MTc2MzAwNDQzNwS2&b=2&j=NjE2NjY4MjcS1&mt=1&rt=0

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Nature Reviews Rheumatology - Table of Contents alert Volume 5 Issue 12

NATURE REVIEWS RHEUMATOLOGY

December 2009 Volume 5 Number 12

Visit Nature Reviews Rheumatology online to browse the journal.

Now available at
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----------------------
RESEARCH HIGHLIGHTS
----------------------
Osteoarthritis: Gait abnormalities, bone mineral density and subchondral
bone loss in knee OA
p653 | doi:10.1038/nrrheum.2009.206
http://links.ealert.nature.com/ctt?kn=24&m=34450454&r=MTc2NDQ4MTc5OAS2&b=2&j=NjE2NjU1NjES1&mt=1&rt=0

Psoriasis: Frankincense-derived triterpenoid improves psoriasis
p654 | doi:10.1038/nrrheum.2009.221
http://links.ealert.nature.com/ctt?kn=22&m=34450454&r=MTc2NDQ4MTc5OAS2&b=2&j=NjE2NjU1NjES1&mt=1&rt=0

Treatment for SLE osteonecrosis
p654 | doi:10.1038/nrrheum.2009.224
http://links.ealert.nature.com/ctt?kn=20&m=34450454&r=MTc2NDQ4MTc5OAS2&b=2&j=NjE2NjU1NjES1&mt=1&rt=0

Connective tissue diseases: Microvascular clues to macrovascular disease
p655 | doi:10.1038/nrrheum.2009.222
http://links.ealert.nature.com/ctt?kn=18&m=34450454&r=MTc2NDQ4MTc5OAS2&b=2&j=NjE2NjU1NjES1&mt=1&rt=0

IN BRIEF
Connective tissue diseases | Inflammatory myopathies | Rheumatoid arthritis
p655 | doi:10.1038/nrrheum.2009.223
http://links.ealert.nature.com/ctt?kn=58&m=34450454&r=MTc2NDQ4MTc5OAS2&b=2&j=NjE2NjU1NjES1&mt=1&rt=0

Bone: BCLXL blocks bone resorption
p656 | doi:10.1038/nrrheum.2009.220
http://links.ealert.nature.com/ctt?kn=91&m=34450454&r=MTc2NDQ4MTc5OAS2&b=2&j=NjE2NjU1NjES1&mt=1&rt=0

IN BRIEF
Imaging | Therapy | Experimental arthritis
p656 | doi:10.1038/nrrheum.2009.226
http://links.ealert.nature.com/ctt?kn=60&m=34450454&r=MTc2NDQ4MTc5OAS2&b=2&j=NjE2NjU1NjES1&mt=1&rt=0

----------------------
NEWS AND VIEWS
----------------------
Bone: Serotonin, leptin and the central control of bone remodeling
Clifford J. Rosen
p657 | doi:10.1038/nrrheum.2009.231
Researchers have identified a new molecular pathway for the regulation of
bone and energy metabolism that challenges the conventional view of the
role of leptin in bone turnover.
http://links.ealert.nature.com/ctt?kn=40&m=34450454&r=MTc2NDQ4MTc5OAS2&b=2&j=NjE2NjU1NjES1&mt=1&rt=0

Rheumatoid arthritis: The multifaceted role of adiponectin in inflammatory
joint disease
Ulf Muller-Ladner and Elena Neumann
p659 | doi:10.1038/nrrheum.2009.232
Adipocytokines are usually regarded as signaling molecules that originate
from and act within the adipose tissue. However, recent data show that
adipocytokines, especially adiponectin, exert various functions throughout
the organism that are neither unambiguously protective nor solely harmful.
http://links.ealert.nature.com/ctt?kn=28&m=34450454&r=MTc2NDQ4MTc5OAS2&b=2&j=NjE2NjU1NjES1&mt=1&rt=0

Metabolic bone diseases: Translational research-preventing fractures with
denosumab
Peter R. Ebeling
p660 | doi:10.1038/nrrheum.2009.234
In the late 1990s, bone cell biologists predicted inhibition of RANKL as
an important therapeutic target for osteoporosis. The theory has now been
confirmed by two studies showing that denosumab reduces fracture risk. This
success for translational research should be tempered by awareness of the
need for long-term monitoring for adverse effects.
http://links.ealert.nature.com/ctt?kn=30&m=34450454&r=MTc2NDQ4MTc5OAS2&b=2&j=NjE2NjU1NjES1&mt=1&rt=0

Surgery: Vertebroplasty: one solution does not fit all
Gunnar B. J. Andersson
p662 | doi:10.1038/nrrheum.2009.233
Two randomized controlled trials have shown no significant differences
in outcome between vertebroplasty and a sham procedure in patients with
back pain and vertebral fracture. What conclusions can be drawn from these
results?
http://links.ealert.nature.com/ctt?kn=34&m=34450454&r=MTc2NDQ4MTc5OAS2&b=2&j=NjE2NjU1NjES1&mt=1&rt=0

Metabolic bone diseases: Treating Paget disease: when matters more than how
Jacques P. Brown
p663 | doi:10.1038/nrrheum.2009.230
New research shows that intensive bisphosphonate therapy for Paget disease
of bone has no beneficial effect on quality of life, bone pain or clinical
complications compared with symptomatic management. What are the implications
of these findings on the management of patients with Paget disease?
http://links.ealert.nature.com/ctt?kn=36&m=34450454&r=MTc2NDQ4MTc5OAS2&b=2&j=NjE2NjU1NjES1&mt=1&rt=0

----------------------
REVIEWS
----------------------
Osteoimmunology and the effects of the immune system on bone
Hiroshi Takayanagi
Published online: 03 November 2009
p667 | doi:10.1038/nrrheum.2009.217
The immune and skeletal systems share several molecules, including cells,
cytokines, transcription factors, signaling molecules and membrane receptors.
In rheumatoid arthritis, the synovium is a site of active interplay between
immune cells and bone cells, in which, as outlined in this Review,
osteoclasts are stimulated by cytokines and molecules, such as receptor
activator of nuclear factor [kappa]B ligand, to mediate structural damage.
Abstract: http://links.ealert.nature.com/ctt?kn=54&m=34450454&r=MTc2NDQ4MTc5OAS2&b=2&j=NjE2NjU1NjES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=39&m=34450454&r=MTc2NDQ4MTc5OAS2&b=2&j=NjE2NjU1NjES1&mt=1&rt=0

Vascular effects of biologic agents in RA and spondyloarthropathies
Zoltan Szekanecz, Gyorgy Kerekes and Pal Soltesz
Published online: 10 November 2009
p677 | doi:10.1038/nrrheum.2009.219
Evidence is mounting that biologic agents used to treat rheumatoid arthritis
and other inflammatory rheumatic diseases exert substantial effects not
only on underlying inflammation but also on the vasculature. This article
reviews the available evidence on the effects of infliximab, adalimumab,
etanercept and rituximab on atherosclerosis and cardiovascular disease risk.
Abstract: http://links.ealert.nature.com/ctt?kn=55&m=34450454&r=MTc2NDQ4MTc5OAS2&b=2&j=NjE2NjU1NjES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=3&m=34450454&r=MTc2NDQ4MTc5OAS2&b=2&j=NjE2NjU1NjES1&mt=1&rt=0

Cell-free and cell-based approaches for bone regeneration
Ericka M. Bueno and Julie Glowacki
Published online: 10 November 2009
p685 | doi:10.1038/nrrheum.2009.228
Bone tissue engineering involves the development of viable bone substitutes
that restore and maintain the function of bone tissue. In this article,
the authors provide an overview of the rapidly progressing field of bone
tissue engineering, describing the various approaches at the level of the
scaffold, cells, and growth factors, and identifying the advantages and
limitations of each approach.
Abstract: http://links.ealert.nature.com/ctt?kn=45&m=34450454&r=MTc2NDQ4MTc5OAS2&b=2&j=NjE2NjU1NjES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=7&m=34450454&r=MTc2NDQ4MTc5OAS2&b=2&j=NjE2NjU1NjES1&mt=1&rt=0

Using ultrasonography to facilitate best practice in diagnosis and management
of RA
Andrew K. Brown
Published online: 10 November 2009
p698 | doi:10.1038/nrrheum.2009.227
Musculoskeletal ultrasonography is emerging as a potentially useful tool for
the assessment and management of patients with rheumatoid arthritis. In this
Review, Dr. Andrew Brown describes the diverse applications and advantages of
this imaging modality in the diagnosis, treatment and monitoring of
rheumatoid arthritis in the clinic.
Abstract: http://links.ealert.nature.com/ctt?kn=44&m=34450454&r=MTc2NDQ4MTc5OAS2&b=2&j=NjE2NjU1NjES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=15&m=34450454&r=MTc2NDQ4MTc5OAS2&b=2&j=NjE2NjU1NjES1&mt=1&rt=0

----------------------
CASE STUDY
----------------------
Meticillin-sensitive Staphylococcus aureus costochondritis in a healthy man
Ausaf F. Mohammad, Nicky Ambrose, Ole-Petter R. Hamnvik and Grainne Kearns
p708 | doi:10.1038/nrrheum.2009.216
Septic costochondritis is a rare presentation that is usually seen in
intravenous drug users, patients with diabetes or those receiving long-term
hemodialysis. In this Case Study, the authors describe the diagnosis and
management of this condition in a previously healthy patient without any
of the established risk factors.
Abstract: http://links.ealert.nature.com/ctt?kn=43&m=34450454&r=MTc2NDQ4MTc5OAS2&b=2&j=NjE2NjU1NjES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=49&m=34450454&r=MTc2NDQ4MTc5OAS2&b=2&j=NjE2NjU1NjES1&mt=1&rt=0

----------------------
PERSPECTIVES
----------------------
OPINION
B-cell-depletion therapy in SLE-what are the current prospects for its
acceptance?
Catarina Favas and David A. Isenberg
p711 | doi:10.1038/nrrheum.2009.218
B-cell-depletion therapy emerged as a new therapeutic option for systemic
lupus erythematosus (SLE) about a decade ago. Promising results from several
open-label studies, with respect to efficacy and safety, were marred by the
failure of two large, randomized controlled studies of rituximab to meet
their endpoints. Rather than writing off B-cell depletion, might we
eventually be able to accept it as a useful approach for treating SLE?
Abstract: http://links.ealert.nature.com/ctt?kn=42&m=34450454&r=MTc2NDQ4MTc5OAS2&b=2&j=NjE2NjU1NjES1&mt=1&rt=0
Article: http://links.ealert.nature.com/ctt?kn=56&m=34450454&r=MTc2NDQ4MTc5OAS2&b=2&j=NjE2NjU1NjES1&mt=1&rt=0

=========================== ADVERTISEMENT ===========================

XVI PANAMERICAN CONGRESS OF RHEUMATOLOGY
PANLAR 2010
APRIL 25 - 28, 2010 / SANTIAGO, CHILE
http://links.ealert.nature.com/ctt?kn=86&m=34450454&r=MTc2NDQ4MTc5OAS2&b=2&j=NjE2NjU1NjES1&mt=1&rt=0
info@panlarchile2010.cl

Join us at this meeting that will be distinguished with guests from
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ScienceDirect Alert: Cell, Vol. 139, Iss. 5, 2009

New Volume/Issue is now available on ScienceDirect

Cell Volume 139, Issue 5,  Pages 831-1024 (25 November 2009)

Leading Edge

1.

In This Issue Pages 831, 833

2.

Cancer Biology Select Pages 835, 837

Analysis

3.

Researchers Find Their Nemo Pages 843-846 Anthony King

Commentary

4.

The President's Scientist Pages 847-850 Neal F. Lane, Kirstin R.W. Matthews

Book Review

5.

Let's Get Physical Pages 852-853 Boris I. Shraiman

Essay

6.

Lipid Droplets Finally Get a Little R-E-S-P-E-C-T Pages 855-860 Robert V. Farese Jr., Tobias C. Walther

Previews

7.

Pushing and Pulling: Microtubules Mediate Meiotic Pairing and Synapsis Pages 861-863 Sue L. Jaspersen, R. Scott Hawley

8.

RNAi: Prokaryotes Get in on the Act Pages 863-865 John van der Oost, Stan J.J. Brouns

9.

X Chromosome Inactivation: When Dosage Counts Pages 865-867 Elphège P. Nora, Edith Heard

10.

An Acid-Sensing Channel Sows Fear and Panic Pages 867-869 Stephen Maren

Review

11.

Epithelial-Mesenchymal Transitions in Development and Disease Pages 871-890 Jean Paul Thiery, Hervé Acloque, Ruby Y.J. Huang, M. Angela Nieto

Articles

12.

Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling Pages 891-906 Kandice R. Levental, Hongmei Yu, Laura Kass, Johnathon N. Lakins, Mikala Egeblad, Janine T. Erler, Sheri F.T. Fong, Katalin Csiszar, Amato Giaccia, Wolfgang Weninger, Mitsuo Yamauchi, David L. Gasser, Valerie M. Weaver

13.

Cytoskeletal Forces Span the Nuclear Envelope to Coordinate Meiotic Chromosome Pairing and Synapsis Pages 907-919 Aya Sato, Berith Isaac, Carolyn M. Phillips, Regina Rillo, Peter M. Carlton, David J. Wynne, Roshni A. Kasad, Abby F. Dernburg

14.

Meiotic Chromosome Homology Search Involves Modifications of the Nuclear Envelope Protein Matefin/SUN-1 Pages 920-933 Alexandra M. Penkner, Alexandra Fridkin, Jiradet Gloggnitzer, Antoine Baudrimont, Thomas Machacek, Alexander Woglar, Edina Csaszar, Pawel Pasierbek, Gustav Ammerer, Yosef Gruenbaum, Verena Jantsch

15.

TFB2 Is a Transient Component of the Catalytic Site of the Human Mitochondrial RNA Polymerase Pages 934-944 Marina Sologub, Dmitry Litonin, Michael Anikin, Arkady Mustaev, Dmitry Temiakov

16.

RNA-Guided RNA Cleavage by a CRISPR RNA-Cas Protein Complex Pages 945-956 Caryn R. Hale, Peng Zhao, Sara Olson, Michael O. Duff, Brenton R. Graveley, Lance Wells, Rebecca M. Terns, Michael P. Terns

17.

Rapid E2-E3 Assembly and Disassembly Enable Processive Ubiquitylation of Cullin-RING Ubiquitin Ligase Substrates Pages 957-968 Gary Kleiger, Anjanabha Saha, Steven Lewis, Brian Kuhlman, Raymond J. Deshaies

18.

Neuronal Subtype Specification within a Lineage by Opposing Temporal Feed-Forward Loops Pages 969-982 Magnus Baumgardt, Daniel Karlsson, Javier Terriente, Fernando J. Díaz-Benjumea, Stefan Thor

19.

Assembly of Endogenous oskar mRNA Particles for Motor-Dependent Transport in the Drosophila Oocyte Pages 983-998 Alvar Trucco, Imre Gaspar, Anne Ephrussi

20.

RNF12 Is an X-Encoded Dose-Dependent Activator of X Chromosome Inactivation Pages 999-1011 Iris Jonkers, Tahsin Stefan Barakat, Eskeatnaf Mulugeta Achame, Kim Monkhorst, Annegien Kenter, Eveline Rentmeester, Frank Grosveld, J. Anton Grootegoed, Joost Gribnau

21.

The Amygdala Is a Chemosensor that Detects Carbon Dioxide and Acidosis to Elicit Fear Behavior Pages 1012-1021 Adam E. Ziemann, Jason E. Allen, Nader S. Dahdaleh, Iuliia I. Drebot, Matthew W. Coryell, Amanda M. Wunsch, Cynthia M. Lynch, Frank M. Faraci, Matthew A. Howard III, Michael J. Welsh, John A. Wemmie

Errata

22.

Writing Memories with Light-Addressable Reinforcement Circuitry Page 1022 Adam Claridge-Chang, Robert D. Roorda, Eleftheria Vrontou, Lucas Sjulson, Haiyan Li, Jay Hirsh, Gero Miesenböck

23.

Application of a Translational Profiling Approach for the Comparative Analysis of CNS Cell Types Page 1022 Joseph P. Doyle, Joseph D. Dougherty, Myriam Heiman, Eric F. Schmidt, Tanya R. Stevens, Guojun Ma, Sujata Bupp, Prerana Shrestha, Rajiv D. Shah, Martin L. Doughty, Shiaoching Gong, Paul Greengard, Nathaniel Heintz

SnapShot

24.

SnapShot: Lipid Droplets Pages 1024-1024.e1 Natalie Krahmer, Yi Guo, Robert V. Farese Jr., Tobias C. Walther

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