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Friday, October 31, 2008

ScienceDirect Alert: Cell, Vol. 135, Iss. 3, 2008


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Volume 135, Issue 3,  Pages 369-572 (31 October 2008)


  Leading Edge
 1. In This Issue
Pages 369, 371
 
 2. Neurobiology Select
Pages 373, 375
 
  Essays
 3. Autism: Many Genes, Common Pathways?
Pages 391-395
Daniel H. Geschwind
 
 4. Autism and Brain Development
Pages 396-400
Christopher A. Walsh, Eric M. Morrow and John L.R. Rubenstein
 
 5. The Autistic Neuron: Troubled Translation?
Pages 401-406
Raymond J. Kelleher III and Mark F. Bear
 
  Previews
 6. It Takes a (Dysfunctional) Village to Raise a Tumor
Pages 408-410
Karlyne M. Reilly and Terry Van Dyke
 
 7. Dormant Spores Receive an Unexpected Wake-up Call
Pages 410-412
Peter Setlow
 
 8. A Protein-Only RNase P in Human Mitochondria
Pages 412-414
Scott C. Walker and David R. Engelke
 
 9. Myosin Learns to Recruit AMPA Receptors
Pages 414-415
Eran Perlson and Erika L.F. Holzbaur
 
  Minireview
 10. Knockdown Screens to Knockout HIV-1
Pages 417-420
Stephen P. Goff
 
  Review
 11. The Self-Tuning Neuron: Synaptic Scaling of Excitatory Synapses
Pages 422-435
Gina G. Turrigiano
 
  Articles
 12. Nf1-Dependent Tumors Require a Microenvironment Containing Nf1+/−- and c-kit-Dependent Bone Marrow
Pages 437-448
Feng-Chun Yang, David A. Ingram, Shi Chen, Yuan Zhu, Jin Yuan, Xiaohong Li, Xianlin Yang, Scott Knowles, Whitney Horn, Yan Li, Shaobo Zhang, Yanzhu Yang, Saeed T. Vakili, Menggang Yu, Dennis Burns, Kent Robertson, Gary Hutchins, Luis F. Parada and D. Wade Clapp
 
 13. The Growth Factor Environment Defines Distinct Pluripotent Ground States in Novel Blastocyst-Derived Stem Cells
Pages 449-461
Yu-Fen Chou, Hsu-Hsin Chen, Maureen Eijpe, Akiko Yabuuchi, Joshua G. Chenoweth, Paul Tesar, Jun Lu, Ronald D.G. McKay and Niels Geijsen
 
 14. RNase P without RNA: Identification and Functional Reconstitution of the Human Mitochondrial tRNA Processing Enzyme
Pages 462-474
Johann Holzmann, Peter Frank, Esther Löffler, Keiryn L. Bennett, Christopher Gerner and Walter Rossmanith
 
 15. The MatP/matS Site-Specific System Organizes the Terminus Region of the E. coli Chromosome into a Macrodomain
Pages 475-485
Romain Mercier, Marie-Agnès Petit, Sophie Schbath, Stéphane Robin, Meriem El Karoui, Frédéric Boccard and Olivier Espéli
 
 16. A Eukaryotic-like Ser/Thr Kinase Signals Bacteria to Exit Dormancy in Response to Peptidoglycan Fragments
Pages 486-496
Ishita M. Shah, Maria-Halima Laaberki, David L. Popham and Jonathan Dworkin
 
 17. An Assembly Chaperone Collaborates with the SMN Complex to Generate Spliceosomal SnRNPs
Pages 497-509
Ashwin Chari, Monika M. Golas, Michael Klingenhäger, Nils Neuenkirchen, Bjoern Sander, Clemens Englbrecht, Albert Sickmann, Holger Stark and Utz Fischer
 
 18. Rac Activation and Inactivation Control Plasticity of Tumor Cell Movement
Pages 510-523
Victoria Sanz-Moreno, Gilles Gadea, Jessica Ahn, Hugh Paterson, Pierfrancesco Marra, Sophie Pinner, Erik Sahai and Christopher J. Marshall
 
 19. Undertaker, a Drosophila Junctophilin, Links Draper-Mediated Phagocytosis and Calcium Homeostasis
Pages 524-534
Leigh Cuttell, Andrew Vaughan, Elizabeth Silva, Claire J. Escaron, Mark Lavine, Emeline Van Goethem, Jean-Pierre Eid, Magali Quirin and Nathalie C. Franc
 
 20. Myosin Vb Mobilizes Recycling Endosomes and AMPA Receptors for Postsynaptic Plasticity
Pages 535-548
Zhiping Wang, Jeffrey G. Edwards, Nathan Riley, D. William Provance Jr., Ryan Karcher, Xiang-dong Li, Ian G. Davison, Mitsuo Ikebe, John A. Mercer, Julie A. Kauer and Michael D. Ehlers
 
 21. Neurofibromin Regulation of ERK Signaling Modulates GABA Release and Learning
Pages 549-560
Yijun Cui, Rui M. Costa, Geoffrey G. Murphy, Ype Elgersma, Yuan Zhu, David H. Gutmann, Luis F. Parada, Istvan Mody and Alcino J. Silva
 
  Resource
 22. Anatomical Profiling of G Protein-Coupled Receptor Expression
Pages 561-571
Jean B. Regard, Isaac T. Sato and Shaun R. Coughlin
 
  SnapShot
 23. SnapShot: The Hormonal Control of Food Intake
Pages 572.e1-572.e2
Anthony P. Coll, Giles S.H. Yeo, I. Sadaf Farooqi and Stephen O'Rahilly
 


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Signaling Update contents for 31 October 2008

*********************************************************************
Signaling Gateway - 31 October 2008
http://ealerts.nature.com/cgi-bin24/DM/y/eoXw0Xztnp0H2W0M40EZ
*********************************************************************

Signaling Update is a one-stop online resource designed to keep you
in touch with the latest and most exciting research in cell
signaling. New content is uploaded every Friday.

*********************************************************************
In Signaling Update this week:

------------------------
Featured Article
------------------------
TYROSINE KINASES: AN ABL GATEKEEPER

Mutation of a threonine near the active site of tyrosine kinases
leads to persistent kinase activation and drug resistance.

Original research paper: Nature Structural & Molecular Biology 15,
1109-1118 (2008)

http://ealerts.nature.com/cgi-bin24/DM/y/eoXw0Xztnp0H2W0vP0Ei

------------------------
Molecule Pages
------------------------
The Molecule Pages - A comprehensive, relational, signaling database.
Each week we highlight an expert-authored, peer-reviewed Molecule Page.

PCAF lysine acetyltransferase
http://ealerts.nature.com/cgi-bin24/DM/y/eoXw0Xztnp0H2W0CAKW0EK

PCAF is a nuclear lysine acetyltransferase that acetylates lysine 14
of histone H3 and lysines 8 and 16 of histone H4, in addition to many
transcription factors and several cytosolic proteins. Despite its
ubiquitous expression, PCAF knockout mice show only a mild phenotype,
including deficits in long-term memory and an exaggerated response to
acute stress, forced swimming and conditioned fear.

Also published this week:

MOZ lysine acetyltransferase
http://ealerts.nature.com/cgi-bin24/DM/y/eoXw0Xztnp0H2W0CAKX0EL

MORF lysine acetyltranferase
http://ealerts.nature.com/cgi-bin24/DM/y/eoXw0Xztnp0H2W0CAKY0EM

Vangl2
http://ealerts.nature.com/cgi-bin24/DM/y/eoXw0Xztnp0H2W0CAKZ0EN

Arf-like protein 6
http://ealerts.nature.com/cgi-bin24/DM/y/eoXw0Xztnp0H2W0CAKa0EU

Arf-like protein 4C
http://ealerts.nature.com/cgi-bin24/DM/y/eoXw0Xztnp0H2W0CAKb0EV

Plasma membrane calcium transporting ATPase isoform 4
http://ealerts.nature.com/cgi-bin24/DM/y/eoXw0Xztnp0H2W0CAKc0EW

5-Hydroxytryptamine receptor 2C
http://ealerts.nature.com/cgi-bin24/DM/y/eoXw0Xztnp0H2W0CAKd0EX

Search the molecule pages
http://ealerts.nature.com/cgi-bin24/DM/y/eoXw0Xztnp0H2W0BUuz0Eu

-------------------
Selected Updates
-------------------
MEMBRANE TRAFFICKING: ENDURANCE OF THE WEAKEST SIGNAL
Strongly activated STAT3 diffuses from the cytoplasm into the
nucleus, whereas weakly activated STAT3 is shepherded to the nucleus
by a microtubule-dependent process.
Original research paper: J. Cell Biol. 182, 855-863 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/eoXw0Xztnp0H2W0CAKe0EY

GENETICS: MORE THAN ONE WAY....
Unbiased, systematic approaches to cataloging the genetic alterations
in cancer should lead to a comprehensive understanding of the changes
that occur during tumor development and treatment.
Original research paper: Nature 455, 1061-1068 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/eoXw0Xztnp0H2W0CAKf0EZ

TRANSCRIPTOMICS: THERE'S NOTHING ABNORMAL ABOUT CHIMERIC RNA
Trans-splicing of individual mRNAs resulting in the fusion of the
first 3 exons of JAZF1 to the last 15 exons of JJAZ1 has been
detected in endometrial cancers, but may also play a role in
protecting normal endometrial cells from apoptosis.
Original research paper: Science 321, 1357-1361 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/eoXw0Xztnp0H2W0CAKg0Ea

More Updates:
http://ealerts.nature.com/cgi-bin24/DM/y/eoXw0Xztnp0H2W0vO0Eh

------------------------
Research Library
------------------------
GLYCOGEN SYNTHASE KINASE 3 IN MLL LEUKAEMIA MAINTENANCE AND TARGETED
THERAPY
Nature 455, 1205-1209 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/eoXw0Xztnp0H2W0CAKh0Eb

PROOF-BY-SYNTHESIS OF THE TRANSCRIPTIONAL LOGIC OF MAMMALIAN
CIRCADIAN CLOCKS
Nature Cell Biology 10, 1154-1163 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/eoXw0Xztnp0H2W0CAKi0Ec

A SODIUM-MEDIATED STRUCTURAL SWITCH THAT CONTROLS THE SENSITIVITY OF
KIR CHANNELS TO PtdIns(4,5)P2
Nature Chemical Biology 4, 624-631 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/eoXw0Xztnp0H2W0CAKj0Ed

------------------------
Signaling News
------------------------
NATURE AWARDS FOR MENTORING IN SCIENCE – GERMANY
http://ealerts.nature.com/cgi-bin24/DM/y/eoXw0Xztnp0H2W0BsoK0EX

The winners of the annual Nature Awards for Mentoring in Science have
been announced. The 2008 awards invited nominations from Germany,
with two prizes of €10,000 - one for a mid-career scientist and one
for lifetime achievement. Klass Bergmann of the Technical University
of Kaiserslautern and Heinrich Betz, director of the Max Planck
Institute for Brain Research, Frankfurt share the lifetime
achievement award. Peer Bork of the European Molecular Biology
Laboratory, Heidelberg won the mid-career achievement award.
http://ealerts.nature.com/cgi-bin24/DM/y/eoXw0Xztnp0H2W0Btvx0EQ

More News
http://ealerts.nature.com/cgi-bin24/DM/y/eoXw0Xztnp0H2W0Crw0EQ

-------------------------
Gateway Updates
-------------------------
THE FUNCTIONAL GLYCOMICS GATEWAY - OCTOBER UPDATE
http://ealerts.nature.com/cgi-bin24/DM/y/eoXw0Xztnp0H2W0BKHW0EQ

The Functional Glycomics Gateway is a comprehensive FREE online
resource to keep you abreast of the latest findings in the field.

This month's update features:
Bacterial glycans and mammalian lectins: A precarious balance
http://ealerts.nature.com/cgi-bin24/DM/y/eoXw0Xztnp0H2W0B7XP0EF

Protein O-glycosylation: Drosophila on acid
http://ealerts.nature.com/cgi-bin24/DM/y/eoXw0Xztnp0H2W0B7XQ0EG

Sign up to receive the monthly table of contents e-alert for the
Functional Glycomics Update.
http://ealerts.nature.com/cgi-bin24/DM/y/eoXw0Xztnp0H2W0BJYw0EE

-----------------------------
Signaling Job of the Week
-----------------------------
Postdoctoral position
Employer: Cancer Research Center of Salamanca
Location: Salamanca, Spain
http://ealerts.nature.com/cgi-bin24/DM/y/eoXw0Xztnp0H2W0CAKk0Ee

A postdoctoral position is available in the laboratory of
Dr. Xosé Bustelo at the Centro de Investigacion del Cancer
(Cancer Research Center) of Salamanca, Spain. Studies in the
laboratory focus on the functional characterization of Ras/Rho
superfamily GTPases and their regulators. The successful applicant
will study the cytoskeletal regulators involved in cancer and other
diseases.

More Jobs:
http://ealerts.nature.com/cgi-bin24/DM/y/eoXw0Xztnp0H2W0BnjC0EF

To advertise a job in this spot, please contact Naturejobs.
http://ealerts.nature.com/cgi-bin24/DM/y/eoXw0Xztnp0H2W0vqs0EC

======================================================================

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Genentech is a leading biotechnology company that discovers,
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The company has headquarters in South San Francisco, California,
and is traded on the New York Stock Exchange under the symbol DNA.

http://ealerts.nature.com/cgi-bin24/DM/y/eoXw0Xztnp0H2W0dIO0Ec
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---------------------------------------------------------------------

Nature Clinical Practice Nephrology - Table of Contents alert Volume 4 Issue 11

NATURE CLINICAL PRACTICE NEPHROLOGY

November 2008 Volume 4 Number 11

Visit Nature Clinical Practice Nephrology online to browse the journal.

Now available at http://ealerts.nature.com/cgi-bin24/DM/y/eoYW0Xztnp0HjK0o5F0EX

=====================================================================

Renew your ISN membership today! receive reduced rate and reclaim your
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- 24 x Kidney International
- 12 NCP Nephrology
- Full access to the Gateway
- Special rates at ISN's international Events

http://ealerts.nature.com/cgi-bin24/DM/y/eoYW0Xztnp0HjK0B6lW0Es

=====================================================================

Metabolic Syndrome - now affecting over 25% of the world's population.

The 'Metabolic Syndrome 2008' web focus showcases a collection of
original research articles from our Academic and Clinical Practice
titles that provide further insight into this global disease.

8 distinguished titles, 16 insightful articles, one growing epidemic.

View 'Metabolic Syndrome 2008' online FREE of charge at
http://ealerts.nature.com/cgi-bin24/DM/y/eoYW0Xztnp0HjK0B7MF0E6

=====================================================================

----------------------
EDITORIAL
----------------------
Addressing the global shortage of nephrologists
Michael Field
http://ealerts.nature.com/cgi-bin24/DM/y/eoYW0Xztnp0HjK0CAOA0EF

----------------------
RESEARCH HIGHLIGHTS
----------------------
Nonalcoholic fatty liver disease is a risk factor for CKD in patients
with type 2 diabetes
http://ealerts.nature.com/cgi-bin24/DM/y/eoYW0Xztnp0HjK0CAOB0EG

Risk of bleeding after kidney biopsy is not increased in individuals
with amyloidosis
http://ealerts.nature.com/cgi-bin24/DM/y/eoYW0Xztnp0HjK0CAOC0EH

Effect of raloxifene on bone mineral density is enhanced in women with
stage 3 CKD
http://ealerts.nature.com/cgi-bin24/DM/y/eoYW0Xztnp0HjK0CAOD0EI

Novel laparoscopic technique permits 'scar-free' donor nephrectomy
http://ealerts.nature.com/cgi-bin24/DM/y/eoYW0Xztnp0HjK0CAOE0EJ

FGF-23: a novel predictor of mortality in patients on hemodialysis?
http://ealerts.nature.com/cgi-bin24/DM/y/eoYW0Xztnp0HjK0CAOF0EK

New protocol reduces acute renal allograft rejection rate in patients
with HIV
http://ealerts.nature.com/cgi-bin24/DM/y/eoYW0Xztnp0HjK0CAOG0EL

Desensitization for renal transplantation with rituximab and intravenous
immune globulin
http://ealerts.nature.com/cgi-bin24/DM/y/eoYW0Xztnp0HjK0CAOH0EM

Sirolimus reduces left ventricular hypertrophy in renal transplant
recipients
http://ealerts.nature.com/cgi-bin24/DM/y/eoYW0Xztnp0HjK0CAOI0EN

Is it better to perform kidney transplantation during the day than at
night?
http://ealerts.nature.com/cgi-bin24/DM/y/eoYW0Xztnp0HjK0CAOJ0EO

----------------------
PRACTICE POINTS
----------------------
Albuminuria is associated with the incidence of some cancers in
nondiabetic individuals
Yoshiyuki Furumatsu and Enyu Imai
http://ealerts.nature.com/cgi-bin24/DM/y/eoYW0Xztnp0HjK0CAOK0EP

Urinary albumin:total protein ratio-a new diagnostic tool to differentiate
glomerular from nonglomerular hematuria
Julia M Hofstra and Jack FM Wetzels
http://ealerts.nature.com/cgi-bin24/DM/y/eoYW0Xztnp0HjK0CAOL0EQ

Waist:hip ratio is a better predictor of cardiovascular risk than BMI
in patients with moderate CKD
Luca De Nicola and Giuseppe Conte
http://ealerts.nature.com/cgi-bin24/DM/y/eoYW0Xztnp0HjK0CAOM0ER

Contrast nephropathy: are short-term outcome measures adequate for
quantification of long-term renal risk?
Bruce A Molitoris
http://ealerts.nature.com/cgi-bin24/DM/y/eoYW0Xztnp0HjK0CAON0ES

More-intensive renal replacement therapy has no benefit in critically
ill patients with acute kidney injury
Helmut Schiffl
http://ealerts.nature.com/cgi-bin24/DM/y/eoYW0Xztnp0HjK0CAOO0ET

Long-term tacrolimus versus long-term ciclosporin in renal transplant
recipients with poor graft function
James Pattison and Steven Sacks
http://ealerts.nature.com/cgi-bin24/DM/y/eoYW0Xztnp0HjK0CAOP0EU

Assessing the risk of post-transplantation diabetes mellitus with an
oral glucose tolerance test
Phuong-Thu Pham and Phuong-Chi Pham
http://ealerts.nature.com/cgi-bin24/DM/y/eoYW0Xztnp0HjK0CAOQ0EV

----------------------
VIEWPOINTS
----------------------
Daily nocturnal hemodialysis-a paradigm shift worthy of disrupting current
dialysis practice
Andreas Pierratos
http://ealerts.nature.com/cgi-bin24/DM/y/eoYW0Xztnp0HjK0CAOR0EW

A wearable artificial kidney: dream or reality?
Claudio Ronco, Andrew Davenport and Victor Gura
http://ealerts.nature.com/cgi-bin24/DM/y/eoYW0Xztnp0HjK0CAOS0EX

----------------------
REVIEWS
----------------------
Is bowel preparation before colonoscopy a risky business for the kidney?
Yeong-Hau H Lien
http://ealerts.nature.com/cgi-bin24/DM/y/eoYW0Xztnp0HjK0CAOT0EY

Animal toxins and the kidney
Visith Sitprija
http://ealerts.nature.com/cgi-bin24/DM/y/eoYW0Xztnp0HjK0CAOU0EZ

Understanding the pathophysiology of hemodialysis access problems as a
prelude to developing innovative therapies
Charles J Diskin, Thomas J Stokes, Linda M Dansby, Lautrec Radcliff and
Thomas B Carter
http://ealerts.nature.com/cgi-bin24/DM/y/eoYW0Xztnp0HjK0CAOV0Ea

----------------------
CASE STUDY
----------------------
Nodular glomerulosclerosis in a patient with metabolic syndrome without
diabetes
Pierre Souraty, Cynthia C Nast, Rajnish Mehrotra, Lilly Barba, John Martina
and Sharon G Adler
http://ealerts.nature.com/cgi-bin24/DM/y/eoYW0Xztnp0HjK0CAOW0Eb

=====================================================================

FACT or FICTION?

Studies have reported that up to 60% of individuals with schizophrenia
and 68% of those with bipolar disorder are overweight/obese.

Do you know all the facts about obesity? Visit
http://ealerts.nature.com/cgi-bin24/DM/y/eoYW0Xztnp0HjK0B1Dm0EV
to test your knowledge.

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Kidney International Table of Contents alert Volume 74 Issue 10 (Correction)

KIDNEY INTERNATIONAL

November 2008 Volume 74 Number 10, pp 1223 - 1366

----------------------

Renew your ISN Membership today at reduced rates

* 24x Kidney International
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----------------------

FACT or FICTION?

Studies have reported that up to 60% of individuals with schizophrenia and 68% of those with bipolar disorder are overweight/obese.

Do you know all the facts about obesity? Visit www.nature.com/oby/factorfiction to test your knowledge.

----------------------

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Recommend now at http://ealerts.nature.com/cgi-bin24/DM/y/eoYe0Xztnp0Hiy0BjIp0EZ


----------------------
IN THIS ISSUE
----------------------
In this issue
http://ealerts.nature.com/cgi-bin24/DM/y/eoYe0Xztnp0Hiy0CAHv0Ey

----------------------
EDITORIAL
----------------------
Women in Medicine: there is no Hogwarts Sorting Hat for female fellow physicians
Juliane K Unger
http://ealerts.nature.com/cgi-bin24/DM/y/eoYe0Xztnp0Hiy0CAHw0Ez

----------------------
JOURNAL CLUB
----------------------
Journal Club
http://ealerts.nature.com/cgi-bin24/DM/y/eoYe0Xztnp0Hiy0CAHx0E1

----------------------
COMMENTARIES
----------------------
Calcimimetics, parathyroid hormone, and vascular calcification in chronic kidney disease
Giorgio Coen
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eoYe0Xztnp0Hiy0CAHy0E2
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eoYe0Xztnp0Hiy0CAHz0E3

Extracorporeal removal of toxins
Pallavi K Tyagi, James F Winchester and Donald A Feinfeld
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eoYe0Xztnp0Hiy0CAH10Ep
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eoYe0Xztnp0Hiy0CAH20Eq

Interstitial fibrosis: tubular hypothesis versus glomerular hypothesis
Erik I Christensen and Pierre J Verroust
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eoYe0Xztnp0Hiy0CAH30Er
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eoYe0Xztnp0Hiy0CAH40Es

----------------------
MEETING REPORT
----------------------
Clinical practice guidelines for anemia in chronic kidney disease: problems and solutions. A position statement from Kidney Disease: Improving Global Outcomes (KDIGO)
Francesco Locatelli, Allen R Nissenson, Brendan J Barrett, Rowan G Walker, David C Wheeler, Kai U Eckardt, Norbert H Lameire and Garabed Eknoyan
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eoYe0Xztnp0Hiy0CAH50Et
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eoYe0Xztnp0Hiy0CAH60Eu

----------------------
MINI REVIEW
----------------------
TRPV5: an ingeniously controlled calcium channel
Theun de Groot, Rene J M Bindels and Joost G J Hoenderop
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eoYe0Xztnp0Hiy0CAH70Ev
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eoYe0Xztnp0Hiy0CAH80Ew

----------------------
REVIEW
----------------------
Neointimal hyperplasia associated with synthetic hemodialysis grafts
Li Li, Christi M Terry, Yan-Ting E Shiu and Alfred K Cheung
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eoYe0Xztnp0Hiy0CAIA0E7
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eoYe0Xztnp0Hiy0CAIB0E8

----------------------
ORIGINAL ARTICLES
----------------------
Megalin contributes to the early injury of proximal tubule cells during nonselective proteinuria
Yaeko Motoyoshi, Taiji Matsusaka, Akihiko Saito, Ira Pastan, Thomas E Willnow, Shuki Mizutani and Iekuni Ichikawa
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eoYe0Xztnp0Hiy0CAIC0EA
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eoYe0Xztnp0Hiy0CAID0EB

Cinacalcet suppresses calcification of the aorta and heart in uremic rats
Takehisa Kawata, Nobuo Nagano, Masaki Obi, Sonoe Miyata, Chika Koyama, Nami Kobayashi, Sachiko Wakita and Michihito Wada
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eoYe0Xztnp0Hiy0CAIE0EC
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eoYe0Xztnp0Hiy0CAIF0ED

Differential distribution of the Sodium-vitamin C cotransporter-1 along the proximal tubule of the mouse and human kidney
Tamara Castro, Marcela Low, Katterine Salazar, Hernan Montecinos, Manuel Cifuentes, Alejandro J Yanez, Juan Carlos Slebe, Carlos D Figueroa, Karin Reinicke, Maria de los Angeles Garcia, Juan Pablo Henriquez and Francisco Nualart
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eoYe0Xztnp0Hiy0CAIG0EE
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eoYe0Xztnp0Hiy0CAIH0EF

Downregulation of Spry-1, an inhibitor of GDNF//Ret, causes angiotensin II-induced ureteric bud branching
Ihor V Yosypiv, Mary K Boh, Melissa A Spera and Samir S El-Dahr
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eoYe0Xztnp0Hiy0CAII0EG
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eoYe0Xztnp0Hiy0CAIJ0EH

Dendritic cells facilitate accumulation of IL-17 T cells in the kidney following acute renal obstruction
Xiangyang Dong, Lori A Bachman, Melinda N Miller, Karl A Nath and Matthew D Griffin
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eoYe0Xztnp0Hiy0CAIK0EI
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eoYe0Xztnp0Hiy0CAIL0EJ

Neutrophil gelatinase-associated lipocalin suppresses cyst growth by Pkd1 null cells in vitro and in vivo
Feng Wei, Anil Karihaloo, Zhiheng Yu, Arnaud Marlier, Pankaj Seth, Sekiya Shibazaki, Tong Wang, Vikas P Sukhatme, Stefan Somlo and Lloyd G Cantley
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eoYe0Xztnp0Hiy0CAIM0EK
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eoYe0Xztnp0Hiy0CAIN0EL

Increased survival and reduced renal injury in MRL//lpr mice treated with a novel sphingosine-1-phosphate receptor agonist
Scott E Wenderfer, Stanislaw M Stepkowski and Michael C Braun
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eoYe0Xztnp0Hiy0CAIO0EM
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eoYe0Xztnp0Hiy0CAIP0EN

Use of hemodialysis and hemoperfusion in poisoned patients
William J Holubek, Robert S Hoffman, David S Goldfarb and Lewis S Nelson
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eoYe0Xztnp0Hiy0CAIQ0EO
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eoYe0Xztnp0Hiy0CAIR0EP

The association of sudden cardiac death with inflammation and other traditional risk factors
Rulan S Parekh, Laura C Plantinga, W H Linda Kao, Lucy A Meoni, Bernard G Jaar, Nancy E Fink, Neil R Powe, Josef Coresh and Michael J Klag
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eoYe0Xztnp0Hiy0CAIS0EQ
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eoYe0Xztnp0Hiy0CAIT0ER

Reduction of the vitamin D hormonal system in kidney disease is associated with increased renal inflammation
Daniel Zehnder, Marcus Quinkler, Kevin S Eardley, Rosemary Bland, Julia Lepenies, Susan V Hughes, Neil T Raymond, Alexander J Howie, Paul Cockwell, Paul M Stewart and Martin Hewison
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eoYe0Xztnp0Hiy0CAIU0ES
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eoYe0Xztnp0Hiy0CAIV0ET

----------------------
THE RENAL CONSULT
----------------------
Progressive renal insufficiency associated with amiodarone-induced phospholipidosis
Pairach Pintavorn and William J Cook
http://ealerts.nature.com/cgi-bin24/DM/y/eoYe0Xztnp0Hiy0CAIW0EU

----------------------
LETTERS TO THE EDITOR
----------------------
Diuretics should be used as the second-line agent in combination with RAS inhibitors in ptoteinuric patients with CKD
Michio Fukuda and Genjiro Kimura
http://ealerts.nature.com/cgi-bin24/DM/y/eoYe0Xztnp0Hiy0CAIX0EV

Response to `Diuretics should be used as the second-line agent in combination with RAS inhibitors in proteinuric patients with CKD'1
George L Bakris
http://ealerts.nature.com/cgi-bin24/DM/y/eoYe0Xztnp0Hiy0CAIY0EW

The importance of donor privacy
Aaron Spital and James S Taylor
http://ealerts.nature.com/cgi-bin24/DM/y/eoYe0Xztnp0Hiy0CAIZ0EX

Response to `The importance of donor privacy'
Annamaria Maiorano and Francesco P Schena
http://ealerts.nature.com/cgi-bin24/DM/y/eoYe0Xztnp0Hiy0CAIa0Ee

Steroid treatment of drug-induced acute interstitial nephritis
Hussein H Karnib and Fuad N Ziyadeh
http://ealerts.nature.com/cgi-bin24/DM/y/eoYe0Xztnp0Hiy0CAIb0Ef

Response to `Steroid treatment of drug-induced acute interstitial nephritis'
Manuel Praga
http://ealerts.nature.com/cgi-bin24/DM/y/eoYe0Xztnp0Hiy0CAIc0Eg

The adiponectin rs17300539 G>A variant and nephropathy risk
Sarah L Prior, Jabaria Javid, Geoffrey V Gill, Steve C Bain and Jeffrey W Stephens
http://ealerts.nature.com/cgi-bin24/DM/y/eoYe0Xztnp0Hiy0CAId0Eh

----------------------
MAKE YOUR DIAGNOSIS
----------------------
The Case [mid] Triple acid-base disorder after drug abuse
Kenar D Jhaveri and Allison B Webber
http://ealerts.nature.com/cgi-bin24/DM/y/eoYe0Xztnp0Hiy0CAIe0Ei

----------------------
NEPHROLOGY IMAGE
----------------------
Parapelvic cysts leading to a diagnosis of Fabry disease
J A Sayer, P Haslam and P Brennan
http://ealerts.nature.com/cgi-bin24/DM/y/eoYe0Xztnp0Hiy0CAIf0Ej

----------------------

Articles for Kidney International are published online ahead of print through Advance Online Publication (AOP), meaning that the latest research reaches you in the timeliest way possible. Check the AOP webpage each week at www.nature.com/ki/journal/vaop/ncurrent to make sure that you are not left behind.


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Kidney International Table of Contents alert Volume 74 Issue 10

KIDNEY INTERNATIONAL

November 2008 Volume 74 Number 10, pp 1223 - 1366

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Do you know all the facts about obesity? Visit www.nature.com/oby/factorfiction to test your knowledge.

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Recommend now at http://ealerts.nature.com/cgi-bin24/DM/y/eoWz0Xztnp0Hiy0BjIp0Es


----------------------
IN THIS ISSUE
----------------------
In this issue
http://ealerts.nature.com/cgi-bin24/DM/y/eoWz0Xztnp0Hiy0CAHv0EJ

----------------------
EDITORIAL
----------------------
Women in Medicine: there is no Hogwarts Sorting Hat for female fellow physicians
Juliane K Unger
http://ealerts.nature.com/cgi-bin24/DM/y/eoWz0Xztnp0Hiy0CAHw0EK

----------------------
JOURNAL CLUB
----------------------
Journal Club
http://ealerts.nature.com/cgi-bin24/DM/y/eoWz0Xztnp0Hiy0CAHx0EL

----------------------
COMMENTARIES
----------------------
Calcimimetics, parathyroid hormone, and vascular calcification in chronic kidney disease
Giorgio Coen
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eoWz0Xztnp0Hiy0CAHy0EM
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eoWz0Xztnp0Hiy0CAHz0EN

Extracorporeal removal of toxins
Pallavi K Tyagi, James F Winchester and Donald A Feinfeld
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eoWz0Xztnp0Hiy0CAH10EA
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eoWz0Xztnp0Hiy0CAH20EB

Interstitial fibrosis: tubular hypothesis versus glomerular hypothesis
Erik I Christensen and Pierre J Verroust
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eoWz0Xztnp0Hiy0CAH30EC
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eoWz0Xztnp0Hiy0CAH40ED

----------------------
MEETING REPORT
----------------------
Clinical practice guidelines for anemia in chronic kidney disease: problems and solutions. A position statement from Kidney Disease: Improving Global Outcomes (KDIGO)
Francesco Locatelli, Allen R Nissenson, Brendan J Barrett, Rowan G Walker, David C Wheeler, Kai U Eckardt, Norbert H Lameire and Garabed Eknoyan
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eoWz0Xztnp0Hiy0CAH50EE
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eoWz0Xztnp0Hiy0CAH60EF

----------------------
MINI REVIEW
----------------------
TRPV5: an ingeniously controlled calcium channel
Theun de Groot, Rene J M Bindels and Joost G J Hoenderop
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eoWz0Xztnp0Hiy0CAH70EG
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eoWz0Xztnp0Hiy0CAH80EH

----------------------
REVIEW
----------------------
Neointimal hyperplasia associated with synthetic hemodialysis grafts
Li Li, Christi M Terry, Yan-Ting E Shiu and Alfred K Cheung
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eoWz0Xztnp0Hiy0CAIA0ER
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eoWz0Xztnp0Hiy0CAIB0ES

----------------------
ORIGINAL ARTICLES
----------------------
Megalin contributes to the early injury of proximal tubule cells during nonselective proteinuria
Yaeko Motoyoshi, Taiji Matsusaka, Akihiko Saito, Ira Pastan, Thomas E Willnow, Shuki Mizutani and Iekuni Ichikawa
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eoWz0Xztnp0Hiy0CAIC0ET
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eoWz0Xztnp0Hiy0CAID0EU

Cinacalcet suppresses calcification of the aorta and heart in uremic rats
Takehisa Kawata, Nobuo Nagano, Masaki Obi, Sonoe Miyata, Chika Koyama, Nami Kobayashi, Sachiko Wakita and Michihito Wada
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eoWz0Xztnp0Hiy0CAIE0EV
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eoWz0Xztnp0Hiy0CAIF0EW

Differential distribution of the Sodium-vitamin C cotransporter-1 along the proximal tubule of the mouse and human kidney
Tamara Castro, Marcela Low, Katterine Salazar, Hernan Montecinos, Manuel Cifuentes, Alejandro J Yanez, Juan Carlos Slebe, Carlos D Figueroa, Karin Reinicke, Maria de los Angeles Garcia, Juan Pablo Henriquez and Francisco Nualart
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eoWz0Xztnp0Hiy0CAIG0EX
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eoWz0Xztnp0Hiy0CAIH0EY

Downregulation of Spry-1, an inhibitor of GDNF//Ret, causes angiotensin II-induced ureteric bud branching
Ihor V Yosypiv, Mary K Boh, Melissa A Spera and Samir S El-Dahr
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eoWz0Xztnp0Hiy0CAII0EZ
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eoWz0Xztnp0Hiy0CAIJ0Ea

Dendritic cells facilitate accumulation of IL-17 T cells in the kidney following acute renal obstruction
Xiangyang Dong, Lori A Bachman, Melinda N Miller, Karl A Nath and Matthew D Griffin
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eoWz0Xztnp0Hiy0CAIK0Eb
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eoWz0Xztnp0Hiy0CAIL0Ec

Neutrophil gelatinase-associated lipocalin suppresses cyst growth by Pkd1 null cells in vitro and in vivo
Feng Wei, Anil Karihaloo, Zhiheng Yu, Arnaud Marlier, Pankaj Seth, Sekiya Shibazaki, Tong Wang, Vikas P Sukhatme, Stefan Somlo and Lloyd G Cantley
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eoWz0Xztnp0Hiy0CAIM0Ed
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eoWz0Xztnp0Hiy0CAIN0Ee

Increased survival and reduced renal injury in MRL//lpr mice treated with a novel sphingosine-1-phosphate receptor agonist
Scott E Wenderfer, Stanislaw M Stepkowski and Michael C Braun
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eoWz0Xztnp0Hiy0CAIO0Ef
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eoWz0Xztnp0Hiy0CAIP0Eg

Use of hemodialysis and hemoperfusion in poisoned patients
William J Holubek, Robert S Hoffman, David S Goldfarb and Lewis S Nelson
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eoWz0Xztnp0Hiy0CAIQ0Eh
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eoWz0Xztnp0Hiy0CAIR0Ei

The association of sudden cardiac death with inflammation and other traditional risk factors
Rulan S Parekh, Laura C Plantinga, W H Linda Kao, Lucy A Meoni, Bernard G Jaar, Nancy E Fink, Neil R Powe, Josef Coresh and Michael J Klag
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eoWz0Xztnp0Hiy0CAIS0Ej
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eoWz0Xztnp0Hiy0CAIT0Ek

Reduction of the vitamin D hormonal system in kidney disease is associated with increased renal inflammation
Daniel Zehnder, Marcus Quinkler, Kevin S Eardley, Rosemary Bland, Julia Lepenies, Susan V Hughes, Neil T Raymond, Alexander J Howie, Paul Cockwell, Paul M Stewart and Martin Hewison
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eoWz0Xztnp0Hiy0CAIU0El
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eoWz0Xztnp0Hiy0CAIV0Em

----------------------
THE RENAL CONSULT
----------------------
Progressive renal insufficiency associated with amiodarone-induced phospholipidosis
Pairach Pintavorn and William J Cook
http://ealerts.nature.com/cgi-bin24/DM/y/eoWz0Xztnp0Hiy0CAIW0En

----------------------
LETTERS TO THE EDITOR
----------------------
Diuretics should be used as the second-line agent in combination with RAS inhibitors in ptoteinuric patients with CKD
Michio Fukuda and Genjiro Kimura
http://ealerts.nature.com/cgi-bin24/DM/y/eoWz0Xztnp0Hiy0CAIX0Eo

Response to `Diuretics should be used as the second-line agent in combination with RAS inhibitors in proteinuric patients with CKD'1
George L Bakris
http://ealerts.nature.com/cgi-bin24/DM/y/eoWz0Xztnp0Hiy0CAIY0Ep

The importance of donor privacy
Aaron Spital and James S Taylor
http://ealerts.nature.com/cgi-bin24/DM/y/eoWz0Xztnp0Hiy0CAIZ0Eq

Response to `The importance of donor privacy'
Annamaria Maiorano and Francesco P Schena
http://ealerts.nature.com/cgi-bin24/DM/y/eoWz0Xztnp0Hiy0CAIa0Ex

Steroid treatment of drug-induced acute interstitial nephritis
Hussein H Karnib and Fuad N Ziyadeh
http://ealerts.nature.com/cgi-bin24/DM/y/eoWz0Xztnp0Hiy0CAIb0Ey

Response to `Steroid treatment of drug-induced acute interstitial nephritis'
Manuel Praga
http://ealerts.nature.com/cgi-bin24/DM/y/eoWz0Xztnp0Hiy0CAIc0Ez

The adiponectin rs17300539 G>A variant and nephropathy risk
Sarah L Prior, Jabaria Javid, Geoffrey V Gill, Steve C Bain and Jeffrey W Stephens
http://ealerts.nature.com/cgi-bin24/DM/y/eoWz0Xztnp0Hiy0CAId0E1

----------------------
MAKE YOUR DIAGNOSIS
----------------------
The Case [mid] Triple acid-base disorder after drug abuse
Kenar D Jhaveri and Allison B Webber
http://ealerts.nature.com/cgi-bin24/DM/y/eoWz0Xztnp0Hiy0CAIe0E2

----------------------
NEPHROLOGY IMAGE
----------------------
Parapelvic cysts leading to a diagnosis of Fabry disease
J A Sayer, P Haslam and P Brennan
http://ealerts.nature.com/cgi-bin24/DM/y/eoWz0Xztnp0Hiy0CAIf0E3

----------------------

Articles for Kidney International are published online ahead of print through Advance Online Publication (AOP), meaning that the latest research reaches you in the timeliest way possible. Check the AOP webpage each week at www.nature.com/ki/journal/vaop/ncurrent to make sure that you are not left behind.


======================================================================

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Thursday, October 30, 2008

Stem Cells Express: Newly Published Papers Online

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New Stem Cells Stem Cells Express articles have been made available
(for the period 23 Oct 2008 to 30 Oct 2008):



TISSUE-SPECIFIC STEM CELLS
A Novel Method of Dynamic Culture Surface Expansion Improves Mesenchymal Stem Cell Proliferation and Phenotype
Hicham Majd, Pierre Jean Wipff, Lara Buscemi, Manuel Bueno, Daniel Vonwil, Thomas M. Quinn, Boris Hinz
Stem Cells published 30 October 2008, 10.1634/stemcells.2008-0674
http://stemcells.alphamedpress.org/cgi/content/abstract/2008-0674v1

IFATS Series: Adipose Stromal Cells Adopt a Proangiogenic Phenotype Under the Influence of Hypoxia
Hariharan Thangarajah, Ivan N. Vial, Edwin Chang, Samyra El-ftesi, Michael Januszyk, Edward I. Chang, Josemaria Paterno, Evgenios Neofytou, Michael T. Longaker, Geoffrey C. Gurtner
Stem Cells published 30 October 2008, 10.1634/stemcells.2008-0276
http://stemcells.alphamedpress.org/cgi/content/abstract/2008-0276v1

The multipotency of luteinizing granulosa cells collected from mature ovarian follicles
Katarzyna Kossowska-Tomaszczuk, Christian De Geyter, Maria De Geyter, Ivan Martin, Wolfgang Holzgreve Capra, Arnaud Scherberich, Hong Zhang
Stem Cells published 30 October 2008, 10.1634/stemcells.2008-0233
http://stemcells.alphamedpress.org/cgi/content/abstract/2008-0233v1


EMBRYONIC STEM CELLS/INDUCED PLURIPOTENT STEM CELLS
Generation of T lineage cells from human embryonic stem cells in a feeder free system
Zoran Galic, Scott G. Kitchen, Aparna Subramanian, Greg Bristol, Matthew D. Marsden, Arumugam Balamurugan, Amelia Kacena, Otto Yang, Jerome A. Zack
Stem Cells published 30 October 2008, 10.1634/stemcells.2008-0813
http://stemcells.alphamedpress.org/cgi/content/abstract/2008-0813v1


STEM CELL EPIGENETICS, GENOMICS, AND PROTEOMICS
Chromatin modifications in hematopoietic multipotent and committed progenitors are independent of gene subnuclear positioning relative to repressive compartments
Claire Guillemin, Marta Maleszewska, Adeline Guais, Jérôme Maës, Marie Christine Rouyez, Azzedine Yacia, Serge Fichelson, Michele Goodhardt, Claire Francastel
Stem Cells published 30 October 2008, 10.1634/stemcells.2008-0755
http://stemcells.alphamedpress.org/cgi/content/abstract/2008-0755v1


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News in Brief
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India makes history with launch of Moon mission
http://ealerts.nature.com/cgi-bin24/DM/y/eoVk0Xztnp0Hjm0B86B0EW

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Books and arts
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A snapshot of the invisible
http://ealerts.nature.com/cgi-bin24/DM/y/eoVk0Xztnp0Hjm0B86P0Ek

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Economics needs a scientific revolution
http://ealerts.nature.com/cgi-bin24/DM/y/eoVk0Xztnp0Hjm0B86Q0El

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Condensed-matter physics: Borderline metals
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Brian Pippard (1920-2008)
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-------------------------------

Squeezing and entanglement in a Bose-Einstein condensate
J. Esteve, C. Gross, A. Weller, S. Giovanazzi & M. K. Oberthaler
http://ealerts.nature.com/cgi-bin24/DM/y/eoVk0Xztnp0Hjm0B86k0ED

Marginal breakdown of the Fermi-liquid state on the border of
metallic ferromagnetism
R. P. Smith et al.
http://ealerts.nature.com/cgi-bin24/DM/y/eoVk0Xztnp0Hjm0B86m0EF

Low-speed fracture instabilities in a brittle crystal
J. R. Kermode et al.
http://ealerts.nature.com/cgi-bin24/DM/y/eoVk0Xztnp0Hjm0B86o0EH

Coulomb correlations and the Wigner–Mott transition
A. Camjayi, K. Haule, V. Dobrosavljevic & G. Kotliar
http://ealerts.nature.com/cgi-bin24/DM/y/eoVk0Xztnp0Hjm0CAHW0EL

Deterministic entanglement swapping with an ion-trap quantum computer
M. Riebe et al.
http://ealerts.nature.com/cgi-bin24/DM/y/eoVk0Xztnp0Hjm0CAHX0EM

Detection of heating in current-carrying molecular junctions
by Raman scattering
Zvi Ioffe et al.
http://ealerts.nature.com/cgi-bin24/DM/y/eoVk0Xztnp0Hjm0CAGw0Eq

-------------------------------
Articles
-------------------------------

Optical lattice clocks with non-interacting bosons and fermions
Tomoya Akatsuka, Masao Takamoto & Hidetoshi Katori
http://ealerts.nature.com/cgi-bin24/DM/y/eoVk0Xztnp0Hjm0CAHY0EN

Microrheology of a sticking transition
Prerna Sharma, Shankar Ghosh & S. Bhattacharya
http://ealerts.nature.com/cgi-bin24/DM/y/eoVk0Xztnp0Hjm0CAG60El

Structural and magnetic phase diagram of CeFeAsO1- xFx and its
relation to high-temperature superconductivity
Jun Zhao et al.
http://ealerts.nature.com/cgi-bin24/DM/y/eoVk0Xztnp0Hjm0CAG10Eg

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Nature Methods Contents: November 2008 Volume 5 pp 911 - 988

NATURE METHODS

November 2008 Volume 5 Number 11, pp 911 - 988

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----------------------
EDITORIAL
----------------------
Looking back and moving forward p911
The fourth anniversary of Nature Methods' arrival on the publishing
scene and a change in leadership offer an opportunity for reflection
and editorial fine-tuning.
doi:10.1038/nmeth1108-911
http://ealerts.nature.com/cgi-bin24/DM/y/eoUn0Xztnp0Hi80B8z50EZ

----------------------
CORRESPONDENCE
----------------------
A database of mass spectrometric assays for the yeast
proteome pp913 - 914
Paola Picotti et al.
doi:10.1038/nmeth1108-913
http://ealerts.nature.com/cgi-bin24/DM/y/eoUn0Xztnp0Hi80B8z60Ea

----------------------
RESEARCH HIGHLIGHTS
----------------------
Finding copy-number variants p917
Several studies evaluate high-density single-nucleotide polymorphism
(SNP) arrays for the detection of copy-number variations in human
genomes.
Nicole Rusk
doi:10.1038/nmeth1108-917
http://ealerts.nature.com/cgi-bin24/DM/y/eoUn0Xztnp0Hi80B8z70Eb

SNPing away at anonymity pp918 - 919
New findings challenge the assumption that aggregate genotype data,
in which the single-nucleotide polymorphism (SNP) profiles of many
people are pooled, conceal the identity of the individuals within
that pool.
Natalie de Souza
doi:10.1038/nmeth1108-918a
http://ealerts.nature.com/cgi-bin24/DM/y/eoUn0Xztnp0Hi80B8z80Ec

Evolving a better-expressing GPCR pp918 - 919
Researchers describe a method for evolving G protein-coupled
receptors (GPCRs) with greater stability and enhanced expression.
Allison Doerr
doi:10.1038/nmeth1108-918b
http://ealerts.nature.com/cgi-bin24/DM/y/eoUn0Xztnp0Hi80B81A0EY

News in brief p919
doi:10.1038/nmeth1108-919
http://ealerts.nature.com/cgi-bin24/DM/y/eoUn0Xztnp0Hi80B81B0EZ

Fighting fire with fire p920
A co-infection model of two pathogens in a nematode yields insights
into the complex interaction between the microbes.
Nicole Rusk
doi:10.1038/nmeth1108-920
http://ealerts.nature.com/cgi-bin24/DM/y/eoUn0Xztnp0Hi80B81C0Ea

Microfluidics, microscopy and modeling p922
Researchers use microfluidics, a fluorescent reporter and modeling
to quantify yeast's response to glucose availability.
Allison Doerr
doi:10.1038/nmeth1108-922
http://ealerts.nature.com/cgi-bin24/DM/y/eoUn0Xztnp0Hi80B81D0Eb

----------------------
NEWS AND VIEWS
----------------------
New views into the brain of mice on the move pp925 - 926
A portable fiber-optic epifluorescence microscope allows real-time
imaging of brain function with cellular spatial resolution in freely
moving mice.
Fritjof Helmchen and Carl C H Petersen
doi:10.1038/nmeth1108-925
http://ealerts.nature.com/cgi-bin24/DM/y/eoUn0Xztnp0Hi80B81E0Ec

----------------------
PERSPECTIVE
----------------------
Native mass spectrometry: a bridge between interactomics and
structural biology pp927 - 933
Albert J R Heck
doi:10.1038/nmeth.1265
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eoUn0Xztnp0Hi80B81F0Ed
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eoUn0Xztnp0Hi80B81G0Ee

----------------------
BRIEF COMMUNICATIONS
----------------------
High-speed, miniaturized fluorescence microscopy in freely
moving mice pp935 - 938
A miniature epifluorescence microscope that can be carried by a
freely-moving adult mouse allows cellular-level imaging of neuronal
spiking or measurement of microcirculation during normal behavioral
activities.
Benjamin A Flusberg et al.
doi:10.1038/nmeth.1256
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eoUn0Xztnp0Hi80B81H0Ef
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eoUn0Xztnp0Hi80B81I0Eg

Directed enzyme evolution via small and effective neutral drift
libraries pp939 - 942
Directed evolution experiments usually rely on high-throughput
screening of very large libraries of mutants, but most of the mutants
do not even yield stable, functional proteins. The concept of neutral
drift can be used to generate small but highly polymorphic and stable
mutant libraries as a starting point for further evolution.
Rinkoo D Gupta and Dan S Tawfik
doi:10.1038/nmeth.1262
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eoUn0Xztnp0Hi80B81J0Eh
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eoUn0Xztnp0Hi80B81K0Ei

Fluorescence nanoscopy by ground-state depletion and single-molecule
return pp943 - 945
A simple yet powerful super-resolution imaging approach based on
switching off ordinary fluorophores and localizing those remaining or
regaining fluorescence is illustrated using continuous widefield
illumination and imaging of fixed and living cells labeled with
rhodamine-derived dyes or fluorescent proteins. Biteen et al., also
in this issue, describe related work using the ordinary fluorophore
of EYFP for super-resolution imaging.
Jonas Folling et al.
doi:10.1038/nmeth.1257
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eoUn0Xztnp0Hi80B81L0Ej
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eoUn0Xztnp0Hi80B81M0Ek

Super-resolution imaging in live Caulobacter crescentus cells using
photoswitchable EYFP pp947 - 949
Previous work showed that the commonly used fluorescent protein
EYFP can be bleached and reactivated. Exploiting this property allows
super-resolution in vivo imaging of EYFP-labeled structures in living
bacteria. Folling et al., also in this issue, describe a related approach
for super-resolution imaging using other ordinary fluorophores.
Julie S Biteen et al.
doi:10.1038/nmeth.1258
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eoUn0Xztnp0Hi80B81N0El
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eoUn0Xztnp0Hi80B81O0Em

Linking SNPs to CAG repeat length in Huntington's disease
patients pp951 - 953
To determine long-range linkage between single-nucleotide
polymorphisms (SNPs) and the repeat-containing region of a
disease-related gene, Liu et al. develop SNP linkage by
circularization (SLiC) and lay the groundwork for using
allele-specific RNA interference to target insertion or deletion
mutations in disease-associated genes.
Wanzhao Liu et al.
doi:10.1038/nmeth.1261
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eoUn0Xztnp0Hi80B81P0En
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eoUn0Xztnp0Hi80B81Q0Eo

A noncytotoxic DsRed variant for whole-cell labeling pp955 - 957
Many different red fluorescent proteins display cytotoxicity
substantially higher than EGFP when used for whole-cell labeling
of bacterial and mammalian cells with standard high-level expression
systems. An improved tetrameric red fluorescent protein called
DsRed-Express2 allows high-level labeling with minimal cytotoxicity
comparable to that of EGFP.
Rita L Strack et al.
doi:10.1038/nmeth.1264
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eoUn0Xztnp0Hi80B81R0Ep
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eoUn0Xztnp0Hi80B81S0Eq

=====================================================================
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=====================================================================

----------------------
ARTICLES
----------------------
Decision tree-driven tandem mass spectrometry for shotgun
proteomics pp959 - 964
The two major mechanisms for peptide fragmentation by mass
spectrometry, collision-activated dissociation (CAD) or a newer
method, electron transfer dissociation (ETD), display different
efficacies for different peptide chemistries. A decision tree
algorithm, which can be embedded into instruments with both CAD
and ETD capabilities, selects the optimal fragmentation method to
improve the chances of successful peptide identification.
Danielle L Swaney, Graeme C McAlister and Joshua J Coon
doi:10.1038/nmeth.1260
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eoUn0Xztnp0Hi80B81T0Er
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eoUn0Xztnp0Hi80B81U0Es

A nano-positioning system for macromolecular structural
analysis pp965 - 971
The combination of single-molecule fluorescence resonance energy
transfer measurements of multiple dye pairs with probabilistic data
analysis allows quantitative measurement of the position of flexible
domains in macro-molecular complexes. The method was used to
determine the three-dimensional probability density of the position
of RNA exiting the transcription elongation complex.
Adam Muschielok et al.
doi:10.1038/nmeth.1259
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eoUn0Xztnp0Hi80B81V0Et
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eoUn0Xztnp0Hi80B81W0Eu

=====================================================================
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=====================================================================

----------------------
PROTOCOL
----------------------
Correlative light-electron microscopy (CLEM) combining live-cell
imaging and immunolabeling of ultrathin cryosections pp973 - 980
Carolien van Rijnsoever, Viola Oorschot and Judith Klumperman
doi:10.1038/nmeth.1263
http://ealerts.nature.com/cgi-bin24/DM/y/eoUn0Xztnp0Hi80B81Y0Ew

----------------------
TECHNOLOGY FEATURE
----------------------
Neuroscience tools: brain insights pp981 - 987
Researchers at two Boston-based neuroscience centers are working to
develop new imaging tools and technology with the hope of discovering
the secrets behind how the brain functions.
Nathan Blow
doi:10.1038/nmeth1108-981
http://ealerts.nature.com/cgi-bin24/DM/y/eoUn0Xztnp0Hi80B81Z0Ex

----------------------
ERRATUM
----------------------
Erratum: Tracking the structural dynamics of proteins in solution
using time-resolved wide-angle X-ray scattering p988
Marco Cammarata et al.
doi:10.1038/nmeth1108-988
http://ealerts.nature.com/cgi-bin24/DM/y/eoUn0Xztnp0Hi80B81a0E5

----------------------
APPLICATION NOTES
----------------------
Transiently produced recombinant proteins to speed up the
decision-making process and limit risks
Andre Sobczyk, Flavien Carpentier and Sebastien Paris
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eoUn0Xztnp0Hi80B81b0E6
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eoUn0Xztnp0Hi80B81c0E7

Harnessing multimodality to enhance quantification and
reproducibility of in vivo molecular imaging data
Gilbert D Feke et al.
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eoUn0Xztnp0Hi80B81d0E8
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eoUn0Xztnp0Hi80B81e0EA

Bioluminescence microscopy for cellular level circadian analysis
in the suprachiasmatic nucleus
Werner Kammerloher
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eoUn0Xztnp0Hi80B81f0EB
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eoUn0Xztnp0Hi80B81g0EC

=====================================================================
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