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Tuesday, July 31, 2007

Keyword News: [stem cell]

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Tuesday, July 31, 2007 11:31 PM PDT

Controversy about stem cell research continues
Maneater Tue, 31 Jul 2007 5:00 PM PDT
Furor over embryonic stem-cell research in Missouri continued Wednesday, once again reaching the national spotlight, as objections to an upcoming fundraiser performance by MU graduate Sheryl Crow for a Catholic charity have led to the resignation of a St. Louis archbishop from the hospital board.

Company Profile for International Stem Cell Corporation
Business Wire via Yahoo! Finance Tue, 31 Jul 2007 2:24 PM PDT
----International Stem Cell Corporation is a California-based, stem cell company currently focused on developing therapeutic and research products. In the area of therapeutic product development, ISCO's objective is to create an unlimited source of human cells for use in the treatment of several diseases, including diabetes, liver disease and retinal disease through cell transplant therapy.

New Jersey, North Carolina, Rhode Island Take Actions On Embryonic Stem Cell Research, Fertility Treatment Measures
Medical News Today Tue, 31 Jul 2007 6:11 AM PDT
The following highlights recent state actions on human embryonic stem cell research and fertility treatment-related legislation. Embryonic Stem Cell Research New Jersey: Gov. Jon Corzine (D) on Thursday signed a bill that authorizes a Nov. [click link for full article]

National Stem Cell Holding, Inc. to Complete the Audit of its Financial Statements
PR Newswire via Yahoo! Finance Tue, 31 Jul 2007 6:47 AM PDT
National Stem Cell Holding, Inc. , today announced that it is diligently working to complete the audit of its consolidated financial statements for the fiscal years ended December 31, 2005 and December 31, 2006, and for the quarters ended March 31, 2007, June 30, 2007 and August 31, 2007.

Stem cell therapy rescues motor neurons in ALS model
EurekAlert! Tue, 31 Jul 2007 5:07 PM PDT
MADISON -- In a study that demonstrates the promise of cell-based therapies for diseases that have proved intractable to modern medicine, a team of scientists from the University of Wisconsin-Madison has shown it is possible to rescue the dying neurons characteristic of amyotrophic lateral sclerosis (ALS), a fatal neuromuscular disorder also known as Lou Gehrig's disease.

Chinese stem cell therapy said to be helping brain-injured Utah woman improve
The Salt Lake Tribune Mon, 30 Jul 2007 11:36 PM PDT
PARK CITY - Belly down on her parents' living room floor, Dena Brehm Gennerman cries as she props herself up on her elbows. The 39-year-old, who suffered a traumatic brain injury two years ago, could be in pain, though it's hard for parents Bob and Eva Brehm to say.

Personalized Stem Cell Lines Available Through Leading Fertility Clinics
Business Wire via Yahoo! Finance Tue, 31 Jul 2007 6:01 AM PDT
SAN FRANCISCO----StemLifeLine, a Bay Area-based life sciences company, announced today that under its new partnership agreements, three United States fertility clinics, the Fertility Laboratories of Colorado , the Nevada Center for Reproductive Medicine and the Idaho Center for Reproductive Medicine , will now offer individuals who have undergone in vitro fertilization the opportunity to use ...

Fish eyes could hold clue to repairing damaged retinas in humans
EurekAlert! Tue, 31 Jul 2007 7:52 AM PDT
A special type of cell found in the eye has been found to be very important in regenerating the retina in zebrafish and restoring vision even after extensive damage. Now, a UK team of scientists believe they may be able to use these cells -- known as Müller glial cells -- to regenerate damaged retina in humans, according to a study published this month in the journal Stem Cells.

Fish Eyes Could Hold Clue To Repairing Damaged Retinas In Humans
Science Daily Tue, 31 Jul 2007 8:03 AM PDT
A special type of cell found in the eye has been found to be very important in regenerating the retina in zebrafish and restoring vision even after extensive damage. Scientists believe they may be able to use these cells -- known as Müller glial cells -- to regenerate damaged retina in humans, according to a new study published in Stem Cells.




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Monday, July 30, 2007

Keyword News: [stem cell]

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Monday, July 30, 2007 11:31 PM PDT

Stem cell center has 4th faculty member
The Ann Arbor News Mon, 30 Jul 2007 7:47 AM PDT
With the arrival of researcher Ivan Maillard, the center for stem cell biology at the University of Michigan has four faculty members. Announced in 2005, the stem cell center is part of the Life Sciences Institute and a sign that U-M is giving stem cell research increasing emphasis.

Int. Society for Stem Cell Research Enjoys Record Success of 5th Annual Meeting, Names 2007 Award Winners
Newswise Mon, 30 Jul 2007 8:29 AM PDT
International Society for Stem Cell Research (ISSCR) names 2007 Award Winners and discusses success of the 5th ISSCR Annual Meeting.

Right to Life group planning stem cell research forum
Asheville Citizen-Times Mon, 30 Jul 2007 8:09 AM PDT
HENDERSONVILLE - The Henderson/Buncombe chapter of N.C. Right to Life will sponsor a forum on stem cell research at 7 p.m. Tuesday in the Kaplan Auditorium at the Hendersonville Main Library.

7th International Stem Cell Conference being held Oct. 29-30, 2007 in Pittsburgh, PA
Business Wire via Yahoo! Finance Mon, 30 Jul 2007 1:20 PM PDT
NEW YORK----Strategic Research Institute is proud to present its 7th International Stem Cell Conference being held Oct. 29-30, 2007 in Pittsburgh, PA. Bringing together the leading researchers with top tier investors and business development professionals, this event is your greatest opportunity this year to meet, network and develop the partnerships necessary to getting your product on the path ...

Policy puts future of stem cell tests in doubt
Boston Globe Mon, 30 Jul 2007 1:38 AM PDT
WASHINGTON -- With the active encouragement of the Bush administration, US scientists in the past year have developed several methods for creating embryonic stem cells without having to destroy human embryos.

System To Analyze Beating Heart Stem Cells Could Lead To Heart Attack Treatments
Science Daily Mon, 30 Jul 2007 8:04 AM PDT
New research is paving the way for techniques that use stem cells to repair the damage caused by heart attacks. The research is looking at the process that turns a stem cell into a cardiomyocyte -- the beating cell that makes up the heart.

Stem cells may aid heart attack victims
Moldova.org Mon, 30 Jul 2007 8:32 AM PDT
British scientists are studying turning stem cells into cardiomyocytes -- the beating cells found in the heart -- as a way to repair heart attack damage.The University of Nottingham researchers are developing a system that uses electrophysiology to record the electrical properties in a cell. It will be the first time such a system has been used to study cardiomyocyte cells in the United ...

Family to take blind baby to China for experimental stem cell therapy
Sarasota Herald-Tribune Mon, 30 Jul 2007 2:11 AM PDT
They have raised more than $20,000 in donations for a treatment that U.S. doctors say does not make sense.

Links
EUActiv Mon, 30 Jul 2007 3:56 AM PDT
"Heterogeneity in Europe's stem cell politics and legislation seriously hinders the advancement of stem cell research and the sharing of biomedical knowledge.




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[StemCells] TREATMENT FOR PARALYSIS

DEAR MEMBERS,

My daughter who is 18 years old has had Japanese Encephalitis 9 year
ago when she was 9. Her brain cells were damaged and consequently
she is paralyzed since then. She can not talk and her limbs are also
paralyzed. She understands everything very well and somehow responds
to our questions. Her memory, sight and hearing are ok. If you want
to know more detail, please let me have your questions.

I am very serious to get her treated by stem cell therapy and want
to take her to any part of the world as early as possible but since
I live in Pakistan I would prefer a neighboring country. I dont know
whether there is any adverse effect of stem cell therapy or not but
during my investigation and discussions with some people I was
informed about the thee major risk factors:

1) Due to any negligence there are chances of contacting aids if
stem cells are obtained from a wrong source.

2) Some after effects cannot be ruled out which could be manifested
even years after the therapy which can cause any of the serious CNS
diseases.

3) I also fear that if I get this procedure done now then will it be
possible to have the same treatment again if needed or it could be
conducted only once. If it could be done only once then it will not
be possible to avail the benefit of advancements which are expected
in the coming days because people told me that at present the
chances of success are not so bright and the extent to which the
improvement is achieved cannot be ascertained. I am not sure if it
is true or only an assumption.

However, since she is in a terrible condition I am ready to take the
risk if the chances of improvement are bright.

It will be immensely useful to me if you will kindly guide me by
giving your opinion in this respect and let me know whether it will
be a good decision for me to get her treated by stem cell therapy
and what do you think would be the chances of success. Also let me
know if you know some good places where I can take her and the
expenses involved.

I will be extremely grateful if anyone can guide me in this respect.


Best regards

Mohammad Iqbal
10-Noorani Centre,
543-Adamjee Dawood Road,
Karachi-74000, Pakistan.

Phone: 92-333-3375410
Fax : (92-21) 2416365

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StemCells subscribers may also be interested in these sites:

Children's Neurobiological Solutions
http://www.CNSfoundation.org/

Cord Blood Registry
http://www.CordBlood.com/at.cgi?a=150123

The CNS Healing Group
http://groups.yahoo.com/group/CNS_Healing
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Sunday, July 29, 2007

Keyword News: [stem cell]

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Sunday, July 29, 2007 11:31 PM PDT

Calif. stem cell company transplanting HQ to Pa. or N.J.
BizJournals Sun, 29 Jul 2007 10:46 PM PDT
The Philadelphia region is in the running for a West Coast stem cell company that is scouting locations on the East Coast for its new corporate headquarters.

Bioethicist Welcomes Closing of Stem Cell Firm
Zenit News Agency Sun, 29 Jul 2007 3:36 PM PDT
PHILADELPHIA, Pennsylvania, JULY 29, 2007 ( Zenit.org ).- A prominent bioethicist says he hopes that the closure of ES Cell International, a leading embryonic stem cell research facility, is a sign of growing realism.

Administration encourages stem-cell work, but won't fund it
The Kansas City Star Sun, 29 Jul 2007 8:51 PM PDT
WASHINGTON | With the active encouragement of the Bush administration, U.S. scientists in the past year have developed several methods for creating embryonic stem cells without having to destroy human embryos.

STEM CELL HOPE
Daily Record Sun, 29 Jul 2007 9:11 PM PDT
STEM cells could repair damage caused by heart attacks, new research claims.

Paraplegic man back on his feet
Adelaide Now Sun, 29 Jul 2007 9:00 PM PDT
COSTLY and controversial stem-cell therapy has helped an Adelaide paraplegic to his feet.

Spout Off
Cape May County Herald Sun, 29 Jul 2007 12:43 PM PDT
TRENTON--New Jersey voters will decide in November whether to borrow $450 million to pay for stem cell research in the State. Governor Corzine signed the stem cell research bond act Thursday. The money would support research on adult and embryonic stem cells for 10 years.




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Saturday, July 28, 2007

Keyword News: [stem cell]

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Saturday, July 28, 2007 11:31 PM PDT

Metastatic Testicular Cancer Patients Cured By High-Dose Chemotherapy Combined With Stem Cell Transplant
Medical News Today Sat, 28 Jul 2007 5:11 PM PDT
Testicular cancer patients who do not respond to traditional therapy can be cured with high-dose chemotherapy and a stem cell transplant, according to an Indiana University School of Medicine report in the New England Journal of Medicine. [click link for full article]

Future of Stem Cell Tests May Hang on Defining Embryo Harm
Washington Post Sat, 28 Jul 2007 4:33 PM PDT
With the active encouragement of the Bush administration, U.S. scientists in the past year have developed several methods for creating embryonic stem cells without having to destroy human embryos.

StemCellPatents.com Applauds Stem Cell Clinic for Autism Publication
Business Wire via Yahoo! Finance Sat, 28 Jul 2007 10:45 AM PDT
TORONTO----StemCellPatents.com , an organization dedicated to dissemination of stem cell patent information, congratulates the Institute of Cellular Medicine for publishing the first peer reviewed paper describing a novel approach for utilizing stem cell therapy for the treatment of autism.

Congress votes to expand stem cell research
Tiscali Sat, 28 Jul 2007 3:44 AM PDT
"If this bill were to become law, American taxpayers would for the first time in our history be compelled to support the deliberate destruction of human embryos," Bush said in a statement. "Crossing that line would be a grave mistake."

Spout Off
Cape May County Herald Sat, 28 Jul 2007 6:57 AM PDT
TRENTON--New Jersey voters will decide in November whether to borrow $450 million to pay for stem cell research in the State. Governor Corzine signed the stem cell research bond act Thursday. The money would support research on adult and embryonic stem cells for 10 years.




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[StemCellInformation] California Stem Cell Report .....Friday, July 27, 2007

Friday, July 27, 2007

Stanford's Chris Scott and His New Stem Cell Blog

A snappy new blog on stem cell issues has popped up at Stanford University, complete with a reading list and podcasts.

Called "The Stem Cell Blog," it is published by Chris Scott, director of Stanford's Program on Stem Cells in Society and author of the book, "Stem Cell Now." (You can find a picture of Scott here.)

The first post dates back to June 26 with a graphic account about research with live pigs. More recently, the blog has a post based on work by Susan Stayn, Stanford's state stem cell legal expert. Called ?What Color is Your State?? it begins like this:
"Taking a cue from Homeland Security, we?ll periodically publish a color-coded ranking of American states and their legislative positions on embryonic stem cell research."
You can also download the state rankings in a PDF file.

We have added The Stem Cell Blog to our links on the left of this site.

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[StemCellInformation] # 352 Tuesday, July 24 , 2007 - MOTORCYCLES AND MONEY: KEYS TO RESEARCH?

 

  # 352 Tuesday, July 24 , 2007 - MOTORCYCLES AND MONEY: KEYS TO RESEARCH?

 

The passion good people bring to the research funding effort never ceases to amaze me.

 

As the scientific world knows, Dr. Hans Keirstead is a man to watch?and, more importantly, to help.

 

If he wins, we all win.

 

His efforts to advance neurological regeneration are mind-boggling. If you ever get a chance to listen to one of his speeches, don?t miss it. Not only does he speak with the flame of utter conviction, and with a depth of understanding that Einstein would approve?but he is actually understandable! (Well, most of the time anyway?anyone who can take the mountain-to-mountain intellectual leaps he does is completely comprehensible?but even I can get enough to know that here is something amazingly valuable.) His talks inspire, give hope, educate, and are sometimes even fun!

 

So here are two outstanding individuals, David Bailey and Ernesto Fonseca, who want to make sure Dr. Hans gets the funding he needs to make the magic happen.

Media Advisory
 

  Paralyzed motocross racers to host event in support of UCI stem cell research
 
EVENT: Motocross racing icons David Bailey and Ernesto Fonseca will host a fundraiser to support the research efforts of Hans Keirstead, co-director of the Sue and Bill Gross Stem Cell Research Center and associate professor in the Reeve-Irvine Research Center at UC Irvine. Keirstead will present his research in hopes of raising money for pre-clinical safety studies of human stem cell therapies to treat spinal cord injuries, spinal muscular atrophy and amyotrophic lateral sclerosis. Bailey and Fonseca suffered spinal cord injuries as professional motocross racers for Team Honda.
DATE: Tuesday, July 24, 2007
TIME: 6:30 p.m.
LOCATION: Oakley USA Corporate Headquarters, 1 Icon, Foothill Ranch, Calif.
 
BACKGROUND: David Bailey was a leading motocross and Supercross racer in the 1980s, winning 30 national races during his eight-year career. In 1987, he crashed during practice and crushed his spinal cord, leaving him paralyzed from the waist down. Bailey has since become an expert motocross television commentator.

Ernesto Fonseca injured his spine in March 2006 while practicing on a California track for the Daytona Supercross. The injury left Fonseca without feeling from his chest down. Born in Costa Rica, Fonesca was named the American Motorcyclist Association Rookie of the Year in 1999, and he was the first to win AMA 125 Supercross titles on both coasts.

Hans Keirstead is a pioneer in the use of human embryonic stem cells in the study of spinal cord injuries. Keirstead?s laboratory was the first in the world to develop a method to restrict human embryonic stem cells so they generate large amounts of only one cell type in high purity. That type of cell, an oligodendrocyte, insulates connections in the spinal cord, allowing for the conduction of electricity. The treatment has improved mobility in rats with spinal cord injuries, and it now is in development for clinical trials.

http://today.uci.edu/images/space.gif http://today.uci.edu/images/space.gif Hans Keirstead Hans Keirstead

David Bailey David Bailey

Ernesto Fonseca Ernesto Fonseca

http://today.uci.edu/images/SPnavline.gif

 

There is an upcoming opportunity to hear Dr. Keirstead speak - August 26 at the Robert and Margrit Mondavi Center, UC Davis.  Visit http://researchforcure.org/events.htm

Don Reed
www.stemcellbattles.com


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[StemCellInformation] # 353 Friday, July 27, 2007 - WHICH WAY, MISSOURI?

# 353 Friday, July 27, 2007 - WHICH WAY, MISSOURI? 

  

The great state of Missouri has been robbed?of eight hundred and fifty million dollars.

 

Who are the thieves? That?s up to you to decide.

 

By my way of thinking, the Republican Party and the Religious Right should divide the guilt. Their political games denied Missouri eight hundred and fifty million dollars, which should have gone to that state?s economy?and to medical research, the fight against incurable disease.

 

First, let us judge the magnitude of what was lost.

 

$850,000,000.00  Big bucks. Thar?s enough to pay for a McDonald?s double cheeseburger for each of America?s three hundred million citizens.

 

How significant is that? Yesterday, another state, New Jersey began a battle to raise $450 million (over ten years) for stem cell research. Governor Jon S. Corzine signed legislation to allow New Jersey voters to make the decision?whether or not to spend $450 million?roughly half the amount of money that was lost to Missouri?

 

And golden California, our glorious Proposition 71, three hundred million a year?and Missouri could have had $850 million?  That?s almost like three extra years of full funding from the number one source in the world.

 

Jim and Virginia Stowers had planned an enormous expansion of their medical research institute in Missouri, but only if full stem cell research would be allowed.

 

The way I see it, the Stowers are heroes. These two cancer survivors have dedicated their fortune?the hard work of their lives-- to the battle against chronic illness.

 

Their motivation?  ?We founded the Institute so our grandchildren may have better options???Jim and Virginia Stowers.

 

But anti-science Republicans attacked the research at every step. They were trying to criminalize the science which may day allow my paralyzed son Roman to fulfill Christopher Reeve?s great prediction, to ?stand up from (his) wheelchair, and walk away from it forever.?

 

The state of Missouri took notice. Citizens came together in the Missouri Cures Coalition, and fought for a Constitutional Amendment.

 

Amendment 2 was offered, saying: ?to ensure that Missouri patients have access to stem cell therapies and cures, that Missouri researchers can conduct stem cell research in the state, and that all such research is conducted safely and ethically, any stem cell research permitted under federal law may be conducted in Missouri, and any stem cell therapies and cures permitted under federal law may be provided to patients in Missouri??

 

A huge battle was fought.

 

The Stowers helped provide a budget. Some trash was talked about them for this, implying they were trying to make a dollar by backing the research. That was dumb, even by the standards of the opposition?the Stowers are billionaires already, they do not need more money?they are actively engaged in giving it away.

 

Of course, the Religious Right and anti-abortion groups went to work, developing and distributing the most poisonous propaganda imaginable. (I have never understood why anti-abortion groups oppose embryonic stem cell research, since there is no pregnancy involved, and therefore no possibility of either a child or an abortion). Conservative churches ignored the Constitutional separation of church and state, and functioned as headquarters for the anti-research efforts. Week after week, lawn signs were passed out in church, and church bulletins and lectures ranted on  and on and on.

 

President George Bush visited Missouri so often it might have been thought he was changing residence.

 

But Missouri won anyway, passing Amendment 2.

 

As The Jurist (University of Pittsburgh School of Law) put it:

 

?What right is more fundamental than a citizen?s right to equal treatment under laws that govern access to medical therapies and cures? On November 7, Missourians stated clearly that they do not want to be second-class citizens when it comes to decisions about the health of their families. By passing Amendment 2, Missouri voters ensured that these important decisions will be made by patients, their families, and their health care providers, not by politicians in the state capital.??November 13, 2006

 

The Stowers Institute could go forward. Happy ending, right?

 

Unfortunately?

 

Religious Right Republicans like Senator Matt Bartle and Representative Jim Lembke are now trying to overturn Amendment 2, trying to block the will of the Show Me state.   They tried to work within the State government to get a bill to overthrow the Amendment. When that didn?t succeed, they supported an initiative to do the same.

 

But I am an outsider, what do I know about Missouri?

 

Good point. So let?s listen to a couple Missourians.

 

Like Henry J. Waters III, publisher of the Columbia Daily Tribune.

 

?Except for the perverse attitude of Missouri Right to Life, the Catholic Conference and their lapdogs in the Missouri General Assembly, life sciences research and development could be one of the largest and most promising industries in our state?

 

??cultural conservatives?are doing all they can in the Missouri legislature to prohibit life sciences research, particularly in the promising area using stem cells...

 

?Amid this poisonous atmosphere, the highly prestigious Stowers Institute for Medical Research? announced it will put on hold resources to fund a major expansion???Henry J. Waters III,  July 3, 2007

 

The Kansas City Star weighed in.

 

?Missouri politicians like to talk about the state?s promise as a bioscience hub? But those same politicians are undermining efforts to advance medical research by pandering to groups opposed to embryonic stem-cell research?

 

?The passage of Amendment 2, which protects all forms of medical research allowable under federal law, should have removed the barriers to scientific progress. But too many lawmakers continue to cower before groups such as Missouri Right to Life.

 

?These lawmakers delude themselves by thinking life science can flourish here if the climate remains hostile to promising forms of stem cell research.??May 22, 2007, the Kansas City Star.

 

How do scientists feel about it?

 

?I couldn?t possibly come to a place where I thought the potentially lifesaving research I want to do could become illegal,? said Dr. Kevin Eggan.???Stem Cell Movement Faces Setbacks?, Andale Gross, AP, July 24, 2007

 

What is the situation right now?

 

A press release from the Stowers Institute for Medical Research states:

 

??the Institute has transferred approximately $850 million? from Missouri non-profit corporations???whoosh, there went the money, out of the state.

 

Is there a chance the money can come back, and Missouri take its rightful place among the great research centers of the world?

 

?We remain steadfastly committed to the search for life-saving cure through research with human embryonic stem cells,? said Bill Neaves, President and CEO of the Stowers Institute?Unfortunately? As long as the political climate in Missouri remains unfavorable, outstanding scientists who work with human embryonic stem cells will prefer to work elsewhere, and Missouri will be denied the opportunity to advance what many consider the single most field of biomedical science.?

 

So the Stowers pulled their money out.

 

However? they also bought 100 acres of land in Kansas City, Missouri?getting ready for the day, whenever it comes, when the politicians get out of the way.

 

The way I see it, the Stowers have faith in us. We should not let them down.

 

So what do we do?

 

I can tell you in two words.

 

We fight.

 

Yesterday, I gave away twenty-five dollars.

 

That?s two ten dollar bills and a five, twelve double cheeseburgers from McDonald?s, or six bridge tolls and a dollar, from an old retired schoolteacher.

 

I plan to do it again, next month, when I can afford it again.

 

That particular $25 went to www.Kay4Congress.com  an up-and-coming Democratic representative, Kay Barnes, stem cell supporter, 21st district, Missouri, USA.

 

The way I see it, people like Ms. Barnes are going to help right a terrible wrong that was done to America. Her opponent is against the research we support. So?I will do what little bit I can to help her, and every stem cell research supportive leader, from whichever party they may come.

 

We are all Missourians. What happens in the Show Me state affects everyone. We can and should take part in that great struggle, supporting leaders like Kay Barnes, and Senator Claire McCaskill, and Senator Chuck Graham, and Representative Teresa Schooley?stem cell research supporters all, working together for the public good.

 

Which way, Missouri?

 

Forward.

 

P.S. A personal message from Donn Rubin, who led Missouri?s Amendment 2 effort:

 

?With Missouri?s world class medical research institutions and its growing life sciences industry, last fall?s vote demonstrated that our citizens want our state to be at the forefront of advancing medicine and finding new cures.   It is disappointing that there remain some politicians and interest groups, in Missouri and around the country that would prefer to go backwards.  These are the same people who used every deception in the book last year in their unsuccessful attempt to defeat the Missouri Stem Cell Amendment.  But they will fail, and I am confident we will soon get past this unfortunate, divisive chapter that has threatened to slow medical progress.?

 

 

Don Reed
www.stemcellbattles.com

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[StemCellInformation] Stem Cell Robbery in Missouri?

Stem Cell Robbery in Missouri?

Fri Jul 27, 2007 at 11:49:03 PM PDT

The great state of Missouri has been robbed— of eight hundred and fifty million dollars.

Who are the thieves? That's up to you to decide.

By my way of thinking, the Republican Party and the Religious Right should divide the guilt.

Stem Cell Research— Robbery in Missouri?

The great state of Missouri has been robbed— of eight hundred and fifty million dollars.

Who are the thieves? That's up to you to decide.

By my way of thinking, the Republican Party and the Religious Right should divide the guilt. Their political games denied Missouri eight hundred and fifty million dollars, which should have gone to that state's economy—and to medical research, the fight against incurable disease.

First, let us judge the magnitude of what was lost.

$850,000,000.00  Big bucks. That's enough to pay for a McDonald's double cheeseburger for each of America's three hundred million citizens.

How significant is that? Yesterday, another state, New Jersey began a battle to raise $450 million (over ten years) for stem cell research. Governor Jon S. Corzine signed legislation to allow New Jersey voters to make the decision—whether or not to spend $450 million—roughly half the amount of money that was lost to Missouri...

And golden California, our glorious Proposition 71, three hundred million a year—and Missouri could have had $850 million?  That's almost like three extra years of full funding from the number one source in the world.

Jim and Virginia Stowers had planned an enormous expansion of their medical research institute in Missouri, but only if full stem cell research would be allowed.

The way I see it, the Stowers are heroes. These two cancer survivors have dedicated their fortune—the hard work of their lives-- to the battle against chronic illness.

Their motivation?  "We founded the Institute so our grandchildren may have better options..."—Jim and Virginia Stowers.

But anti-science Republicans attacked the research at every step. They were trying to criminalize the science which may one day allow my paralyzed son Roman to fulfill Christopher Reeve's great prediction, to "stand up from (his) wheelchair, and walk away from it forever."

The state of Missouri took notice. Citizens came together in the Missouri Coalition for Lifesaving Cures, and fought for a Constitutional Amendment.

Amendment 2 was offered, saying: "to ensure that Missouri patients have access to stem cell therapies and cures, that Missouri researchers can conduct stem cell research in the state, and that all such research is conducted safely and ethically, any stem cell research permitted under federal law may be conducted in Missouri, and any stem cell therapies and cures permitted under federal law may be provided to patients in Missouri..."

A huge battle was fought.

The Stowers helped provide a budget. Some trash was talked about them for this, implying they were trying to make a dollar by backing the research. That was dumb, even by the standards of the opposition—the Stowers are billionaires already, they do not need more money—they are actively engaged in giving it away.

Of course, the Religious Right and anti-abortion groups went to work, developing and distributing the most poisonous propaganda imaginable. (I have never understood why anti-abortion groups oppose embryonic stem cell research, since there is no pregnancy involved, and therefore no possibility of either a child or an abortion). Conservative churches ignored the Constitutional separation of church and state, and functioned as headquarters for the anti-research efforts. Week after week, lawn signs were passed out in church, and church bulletins and lectures ranted on  and on and on.

President George Bush visited Missouri so often it might have been thought he was changing residence.

But Missouri won anyway, passing Amendment 2.

As The Jurist (University of Pittsburgh School of Law) put it:

"What right is more fundamental than a citizen's right to equal treatment under laws that govern access to medical therapies and cures? On November 7, Missourians stated clearly that they do not want to be second-class citizens when it comes to decisions about the health of their families. By passing Amendment 2, Missouri voters ensured that these important decisions will be made by patients, their families, and their health care providers, not by politicians in the state capital."—November 13, 2006

The Stowers Institute could go forward. Happy ending, right?

Unfortunately...

Religious Right Republicans like Senator Matt Bartle and Representative Jim Lembke are now trying to overturn Amendment 2, trying to block the will of the Show Me state.   They tried to work within the State government to get a bill to overthrow the Amendment. When that didn't succeed, they supported an initiative to do the same.

But I am an outsider, what do I know about Missouri?

Good point. So let's listen to a couple Missourians.

Like Henry J. Waters III, publisher of the Columbia Daily Tribune.

"Except for the perverse attitude of Missouri Right to Life, the Catholic Conference and their lapdogs in the Missouri General Assembly, life sciences research and development could be one of the largest and most promising industries in our state...

"...cultural conservatives...are doing all they can in the Missouri legislature to prohibit life sciences research, particularly in the promising area using stem cells...

"Amid this poisonous atmosphere, the highly prestigious Stowers Institute for Medical Research... announced it will put on hold resources to fund a major expansion..."—Henry J. Waters III,  July 3, 2007

The Kansas City Star weighed in.

"Missouri politicians like to talk about the state's promise as a bioscience hub... But those same politicians are undermining efforts to advance medical research by pandering to groups opposed to embryonic stem-cell research...

"The passage of Amendment 2, which protects all forms of medical research allowable under federal law, should have removed the barriers to scientific progress. But too many lawmakers continue to cower before groups such as Missouri Right to Life.

"These lawmakers delude themselves by thinking life science can flourish here if the climate remains hostile to promising forms of stem cell research."—May 22, 2007, the Kansas City Star.

How do scientists feel about it?

"I couldn't possibly come to a place where I thought the potentially lifesaving research I want to do could become illegal," said Dr. Kevin Eggan."—"Stem Cell Movement Faces Setbacks", Andale Gross, AP, July 24, 2007

What is the situation right now?

A press release from the Stowers Institute for Medical Research states:

"...the Institute has transferred approximately $850 million... from Missouri non-profit corporations..."—whoosh, there went the money, out of the state.

Is there a chance the money can come back, and Missouri take its rightful place among the great research centers of the world?

"We remain steadfastly committed to the search for life-saving cure through research with human embryonic stem cells," said Bill Neaves, President and CEO of the Stowers Institute...Unfortunately... As long as the political climate in Missouri remains unfavorable, outstanding scientists who work with human embryonic stem cells will prefer to work elsewhere, and Missouri will be denied the opportunity to advance what many consider the single most field of biomedical science."

So the Stowers pulled their money out.

However... they also bought 100 acres of land in Kansas City, Missouri—getting ready for the day, whenever it comes, when the politicians get out of the way.

The way I see it, the Stowers have faith in us. We should not let them down.

So what do we do?

I can tell you in two words.

We fight.

Yesterday, I gave away twenty-five dollars.

That's two ten dollar bills and a five, twelve double cheeseburgers from McDonald's, or six bridge tolls and a dollar, from an old retired schoolteacher.

I plan to do it again, next month, when I can afford it again.

That particular $25 went to www.Kay4Congress.com  an up-and-coming Democratic representative, Kay Barnes, stem cell supporter, 21st district, Missouri, USA.

The way I see it, people like Ms. Barnes are going to help right a terrible wrong that was done to America. Her opponent is against the research we support. So—I will do what little bit I can to help her, and every stem cell research supportive leader, from whichever party they may come.

We are all Missourians. What happens in the Show Me state affects everyone. We can and should take part in that great struggle, supporting leaders like Kay Barnes, and Senator Claire McCaskill, and Senator Chuck Graham, and Representative Teresa Schooley—stem cell research supporters all, working together for the public good.

Which way, Missouri?

Forward.

P.S. A personal message from Donn Rubin, who led Missouri's Amendment 2 effort:

"With Missouri's world class medical research institutions and its growing life sciences industry, last fall's vote demonstrated that our citizens want our state to be at the forefront of advancing medicine and finding new cures.   It is disappointing that there remain some politicians and interest groups, in Missouri and around the country that would prefer to go backwards.  These are the same people who used every deception in the book last year in their unsuccessful attempt to defeat the Missouri Stem Cell Amendment.  But they will fail, and I am confident we will soon get past this unfortunate, divisive chapter that has threatened to slow medical progress."

Don C. Reed
www.stemcellbattles.com

Tags: stem cells, Missouri, Jim Stowers, Virginia Stowers, coalition, veto, stem cell research, Democrats, Republicans, Amendment 2, Proposition 71, California, Claire McCaskill (D-Sen-MO) (all tags)

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International Society for Cell and Gene Therapy of Cancer 2007 conference in Mumbai


Annual conference of the International Society for Cell and Gene Therapy of Cancer, to be held in Mumbai, India, on 16th to18th November this year. We are delighted to be able to hold this conference in Mumbai, a most important biotechnology hub in India, representing one of the fastest growing biotechnology sectors both academically and industrially. The main theme of the conference this year will be molecular diagnostics and therapeutics in cancer, and our aim is to host a widely inclusive multi-disciplinary conference covering not only cell and gene therapy, but also other important developments in the molecular diagnosis and therapy of cancer. This we hope will ensure both adequate representation of the local interests and expertise, and to encourage a broader exchange of ideas than has been the case at previous ISCGT conferences.

Friday, July 27, 2007

Keyword News: [stem cell]

Yahoo! Alerts Yahoo! News - My Alerts - Edit Alert
Friday, July 27, 2007 11:31 PM PDT

Stem-cell measure to go on ballot
The Philadelphia Inquirer Fri, 27 Jul 2007 10:04 PM PDT
WEST ORANGE, N.J. - Gov. Corzine and lawmakers yesterday urged voters to approve a November ballot measure that would allow the state to borrow $450 million over 10 years to fund stem-cell research.

Business Council CEO named to stem cell board
BizJournals Fri, 27 Jul 2007 2:22 PM PDT
Kenneth Adams, the new president and CEO of the Business Council of New York State Inc., has been named to serve on the Empire State Stem Cell Board.

Stem cell issue on ballot
Asbury Park Press Fri, 27 Jul 2007 1:41 AM PDT
Gov. Jon S. Corzine and lawmakers yesterday urged voters to approve a November ballot measure that would allow the state to borrow $450 million over 10 years to fund stem cell research.

Spitzer establishes stem cell panel
Rochester Democrat and Chronicle Fri, 27 Jul 2007 2:09 AM PDT
State says appointments will go rapidly now, and so too should grant making for stem cell scientists.

SU prof named to stem cell board
The Post-Standard Fri, 27 Jul 2007 2:25 AM PDT
Gov. Eliot Spitzer on Thursday appointed a Syracuse University philosophy professor to serve on the Empire State Stem Cell Board, which will overseeÕ7GorovitzÕ the distribution of $600 million in grants for stem cell research and development.

Agilent Technologies Tools Used To Derive New Type Of Mouse Embryonic Stem Cell That Shares Key Features Of Human ...
BioresearchOnline Fri, 27 Jul 2007 7:34 AM PDT
Using a variety of Agilent Technologies (NYSE:A) genomics tools, researchers at the National Institute of Neurological Disorders and Stroke (NINDS), National Institutes of Health (NIH), and the University of Oxford, U.K., have achieved a major milestone in solving some of the perplexing differences between embryonic stem (ES) cells of humans and mice

Stem Cells Treat Urinary Incontinence
WFTV 9 Orlando Fri, 27 Jul 2007 12:07 PM PDT
About 13-million Americans are living with urinary incontinence. It's a condition that causes the bladder to leak urine. Surgical slings, pills, and exercises are some common treatments. Now new stem cell therapy is offering some patients lasting relief. More On Urinary Incontinence VIDEO: Stem Cells Treat Urinary Incontinence

BrainStorm Cell Therapeutics Has Met Equity Financing Condition
Business Wire via Yahoo! Finance Fri, 27 Jul 2007 5:30 AM PDT
NEW YORK & PETACH TIKVAH, Israel----BrainStorm Cell Therapeutics Inc. , a leading developer of adult stem cell technologies and therapeutics, is pleased to announce that it has met the conditions to the satisfaction of ACCBT Corp. to receive the first portion of the equity financing transaction from ACCBT Corp., a company under the control of Brainstorm's president, Chaim Lebovits, and that it ...




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[StemCells] qPCR NEWSLETTER - July 2007

qPCR NEWSLETTER - July 2007

If this newsletter is not displayed correctly by your email client,
please use following LINK:
http://www.gene-quantification.de/qpcr-news.html

Dear researcher,
dear Gene Quantification page reader,

Our newsletter informs about the latest news in quantitative real-time
PCR (qPCR and qRT-PCR), which are compiled and summarised on the Gene
Quantification homepage. The focus of this newsletter issue is:

- A lot new publications around the normalisation procedure appeared
during the last years:
- Normalisation - Reference Genes - Housekeeping Genes
- Update of our Gene Quantification Page Directory
- Update of the qPCR Webinar page
- qPCR application workshops in autumn in Germany
- qPCR Symposium USA in October/November 2007

----------------------------------------------------------

Normalisation - Reference Genes - Housekeeping Genes

page 1 - http://www.gene-quantification.de/hkg.html
page 2 - http://www.gene-quantification.de/hkg1.html
page 3 - http://www.gene-quantification.de/hkg2.html

Data normalisation in real-time RT-PCR is a further major step in gene
quantification analysis (Bustin 2002, Pfaffl 2001). The reliability of
any relative RT-PCR experiment can be improved by including an
invariant endogenous control (reference gene) in the assay to correct
for sample to sample variations in RT-PCR efficiency and errors in
sample quantification. A biologically meaningful reporting of target
mRNA copy numbers requires accurate and relevant normalisation to some
standard and is strongly recommended in kinetic RT-PCR. But the
quality of normalized quantitative expression data cannot be better
than the quality of the normalizer itself. Any variation in the
normalizer will obscure real changes and produce artifactual changes
(Bustin 2000). Real-time RT-PCR-specific errors in the quantification
of mRNA transcripts are easily compounded with any variation in the
amount of starting material between the samples, e.g. caused by
sample-to-sample variation, variation in RNA integrity, RT efficiency
differences and cDNA sample loading variation (Stahlberg 2003, 2004a,
2004b). This is especially relevant when the samples have been
obtained from different individuals, different tissues and different
time courses, and will result in the misinterpretation of the derived
expression profile of the target genes. Therefore, normalisation of
target gene expression levels must be performed to compensate intra-
and inter-kinetic RT-PCR variations (sample-to-sample and run-to-run
variations) (Pfaffl & Hageleit 2001).

Data normalisation can be carried out against an endogenous
unregulated reference gene transcript or against total cellular DNA or
RNA content (molecules/g total DNA/RNA and concentrations/g total
DNA/RNA). Normalisation according the total cellular RNA content is
increasingly used, but little is known about the total RNA content of
cells or even about the mRNA concentrations. The content per cell or
per gram tissue may vary in different tissues in vivo, in cell culture
(in vitro), between individuals and under different experimental
conditions. Nevertheless, it has been shown that normalisation to
total cellular RNA is the least unreliable method (Bustin 2000 Bustin
2002). It requires an accurate quantification of the isolated total
RNA or mRNA fraction by optical density at 260 nm, Agilent Bioanalyser
2100, or Ribogreen RNA Quantification Kit. Alternatively the rRNA
content has been proposed as an optimal and stable basis for
normalisation, despite reservations concerning its expression levels,
transcription by a different RNA polymerase and possible imbalances in
rRNA and mRNA fractions between different samples (=> RNA and RT ).

To normalize the absolute quantification according to a single
reference gene, a second set of kinetic PCR reactions has to be
performed for the invariant endogenous control on all experimental
samples and the relative abundance values are calculated for internal
control as well as for the target gene. For each target gene sample,
the relative abundance value obtained is divided by the value derived
from the control sequence in the corresponding target gene. The
normalized values for different samples can then directly be compared
(Pfaffl 2001 and => relative expression).

----------------------------------------------------------

A lot new publications around the normalisation procedure appeared
during the last years => please have a look!
Normalization in real-time PCR - page 3 -
http://www.gene-quantification.de/hkg2.html

Development of a new set of reference genes for normalization of
real-time RT-PCR data of porcine backfat and longissimus dorsi muscle,
and evaluation with PPARGC1A.

Selection of reference genes for quantitative real-time PCR in bovine
preimplantation embryos.

Generic normalization method for real-time PCR Application for the
analysis of the mannanase gene expressed in germinating tomato seed.

Simultaneous control of DNA and RNA processing efficiency using a
nucleic acid calibration set.

Universal reference method for real-time PCR gene expression analysis
of preimplantation embryos.

Development and evaluation of canine reference genes for accurate
quanti&#64257;cation of gene expression.

Genome-Wide Identification and Testing of Superior Reference Genes for
Transcript Normalization in Arabidopsis.

Normalizing genes for quantitative RT-PCR in differentiating human
intestinal epithelial cells and adenocarcinomas of the colon.

Statistical Selection of Maintenance Genes for Normalization of Gene
Expressions.

Evaluation of Reference Genes for Studies of Gene Expression in Human
Adipose Tissue.

Validation of rat reference genes for improved quantitative gene
expression analysis using low density arrays.

A Relevant Reference Gene and Normalization for mRNA Real-Time PCR
Quantification in Specimens with Distinct Cell Types and Variant
Integrity.

Quantification of cDNA generated by reverse transcription of total RNA
provides a simple alternative tool for quantitative RT-PCR normalization.

Error propagation in relative real-time reverse transcription
polymerase chain reaction quanti&#64257;cation models: The balance between
accuracy and precision.

Selection of reference genes in mouse embryos and in differentiating
human and mouse ES cells.

Sex-dependent expression of seven housekeeping genes in rat liver.

QuantitativeMulti-Gene Expression Profiling of Primary Prostate Cancer.

Selection of reference genes for quantitative RT-PCR studies in
striped dolphin (Stenella coeruleoalba) skin biopsies.

Genomic DNA standards for gene expression profling in Mycobacterium
tuberculosis.

Housekeeping gene selection for real-time RT-PCR normalization in
potato during biotic and abiotic stress.

Normalization in real-time PCR - page 3 -
http://www.gene-quantification.de/hkg2.html


----------------------------------------------------------

TALKS Update of the qPCR Talk and Webinar page

A lot of interesting TALKs, WEBINARs, SLIDE SHOWs, and PODCASTs from
various speakers, biotec companies, qPCR Events, and international
journals (Nature and Science) are FREE for download. Have a look and
you will definitely something interesting for your scientific work !
http://talks.gene-quantification.info/
http://webinar.gene-quantification.info/

----------------------------------------------------------

INFOPORTAL Protocols on qPCR INFOPORTAL

http://infoportal.gene-quantification.info/

Protocols online is a resource for protocols, including authoritative,
peer-reviewed 'protocols and an interactive network.

NEW => qPCR and Molecular Biology - Discussion Forums

----------------------------------------------------------

Upcoming Events World-wide academic and commercial qPCR Events
http://events.gene-quantification.info/

Symposia, Meetings, Conferences, Workshops, Seminars, Online-Seminars,
qPCR Education Program, ...etc...
Please submit your qPCR event here => events@gene-quantification.info


----------------------------------------------------------

qPCR Symposium USA
http://www.qPCRsymposium.com

Symposium Focus:
Markers, Stem Cells, Single Cell, siRNA, miRNA, Diagnostics,
Immuno-qPCR, Expression Profiling,
Poster Presentation, Workshops in qPCR

----------------------------------------------------------

WORKSHOP


Opening Opening of TATAA Biocenter, Prague =>
http://www.img.cas.cz/ge/TATAAPrague.html
Real time open qPCR course from 21th - 25th May 2007 => download flyer


TATAA Biocenter Germany - qPCR Application workshops

At the TATAA Biocenter Germany we offer qPCR application workshops,
the 3-day Core Module and a 2-day Biostatistics Module. qPCR courses
are held in regularly in Göteborg, Sweden, in English and in
Freising-Weihenstephan, Germany, in German and English, and in Prague,
Czech Republic in English and Czech.
Depending on the occasion the workshop language and the different
prices may apply. Further customized workshops and specialized
trainings will be held as well across Europe and world-wide. TATAA
Biocenter Germany courses are held in cooperation with the Institute
of Physiology, located at the Technical University of Munich, in
Freising-Weihenstephan, near Munich, very close to the Munich Airport
(MUC). For more information and to register for the qPCR application
workshops, please see our web page:

http://tataa.gene-quantification.info/

Course Occasions 2007:
3-day qPCR Core Module (Mon. - Wed.) and 2-day BioStatistics
Module (Thu. - Fri.)

24 - 28th September 2007 (in Freising, Germany, Kurs wird in DEUTSCH
gehalten, German language)
22 - 26th October 2007 (in Freising, Germany, English language)
26 - 30th November 2007 (in Freising, Germany, English language)
Please register here => http://www.tataa.com/


----------------------------------------------------------

Forward Please send the qPCR NEWS to further scientists and friends
who are interested in qPCR !


Best regards,

Michael W. Pfaffl
responsible Editor of the Gene Quantification Pages
http://www.gene-quantification.info

----------------------------------------------------------

If this newsletter is not displayed correctly by your email client,
please use following LINK
The qPCR NEWS and the Gene Quantification Pages are educational sites
with the only purpose of facilitating access to qPCR related
information on the internet. The qPCR NEWS and the Gene
Quantification Pages are edited by Michael W. Pfaffl and powered by
BioScience Events. Copyright © 2005 - 2007 All rights reserved. Any
unauthorized use, reproduction, or transfer of this message or its
contents, in any medium, is strictly prohibited. Disclaimer &
Copyrights are displayed on the homepage www.gene-quantification.com
To subscribe or change your e-mail address in qPCR NEWS, and if you
would like to receive future issues FREE of charge, please send an
e-mail with the subject SUBSCRIBE to
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ScienceDirect Alert: Cell, Vol. 130, Iss. 2, 2007


ScienceDirect

     New Volume/Issue is now available on ScienceDirect     
 
    Cell

   Cell
  Volume 130, Issue 2,  Pages 193-386 (27 July 2007)
 
 
  Leading Edge
 1. In This Issue
Pages 193, 195
 
 2. Neurobiology Select
Pages 197, 199
 
  Obituary
 3. Anne McLaren 1927–2007
Pages 201-203
Patrick Tam and Robin Lovell-Badge
 
  Essay
 4. Specifying Positional Information in the Embryo: Looking Beyond Morphogens
Pages 205-209
Michel Kerszberg and Lewis Wolpert
 
  Previews
 5. Mitochondrial DNA Transcription: Regulating the Power Supply
Pages 211-213
Robert W. Taylor and Douglass M. Turnbull
 
 6. A New Twist in the Transmembrane Signaling Tool-Kit
Pages 213-215
Mark A. Lemmon and Kathryn M. Ferguson
 
 7. A Sweet Sensor for Size-Conscious Bacteria
Pages 216-218
Daisuke Shiomi and William Margolin
 
 8. Listeria InlB Takes a Different Route to Met
Pages 218-219
Esteban Veiga and Pascale Cossart
 
 9. ATP Synthase: Motoring to the Finish Line
Pages 220-221
Alan E. Senior
 
  Review
 10. Cellular Senescence in Cancer and Aging
Pages 223-233
Manuel Collado, Maria A. Blasco and Manuel Serrano
 
  Articles
 11. Structure of the Human Receptor Tyrosine Kinase Met in Complex with the Listeria Invasion Protein InlB
Pages 235-246
Hartmut H. Niemann, Volker Jäger, P. Jonathan G. Butler, Joop van den Heuvel, Sabine Schmidt, Davide Ferraris, Ermanno Gherardi and Dirk W. Heinz
 
 12. Type 5 Adenylyl Cyclase Disruption Increases Longevity and Protects Against Stress
Pages 247-258
Lin Yan, Dorothy E. Vatner, J. Patrick O'Connor, Andreas Ivessa, Hui Ge, Wei Chen, Shinichi Hirotani, Yoshihiro Ishikawa, Junichi Sadoshima and Stephen F. Vatner
 
 13. BLM Ortholog, Sgs1, Prevents Aberrant Crossing-over by Suppressing Formation of Multichromatid Joint Molecules
Pages 259-272
Steve D. Oh, Jessica P. Lao, Patty Yi-Hwa Hwang, Andrew F. Taylor, Gerald R. Smith and Neil Hunter
 
 14. MTERF3 Is a Negative Regulator of Mammalian mtDNA Transcription
Pages 273-285
Chan Bae Park, Jorge Asin-Cayuela, Yolanda Cámara, Yonghong Shi, Mina Pellegrini, Martina Gaspari, Rolf Wibom, Kjell Hultenby, Hediye Erdjument-Bromage, Paul Tempst, Maria Falkenberg, Claes M. Gustafsson and Nils-Göran Larsson
 
 15. Drosophila microRNAs Are Sorted into Functionally Distinct Argonaute Complexes after Production by Dicer-1
Pages 287-297
Klaus Förstemann, Michael D. Horwich, LiangMeng Wee, Yukihide Tomari and Phillip D. Zamore
 
 16. Sorting of Drosophila Small Silencing RNAs
Pages 299-308
Yukihide Tomari, Tingting Du and Phillip D. Zamore
 
 17. Coupling of Rotation and Catalysis in F1-ATPase Revealed by Single-Molecule Imaging and Manipulation
Pages 309-321
Kengo Adachi, Kazuhiro Oiwa, Takayuki Nishizaka, Shou Furuike, Hiroyuki Noji, Hiroyasu Itoh, Masasuke Yoshida and Kazuhiko Kinosita Jr.
 
 18. Structural Basis for Activation of the Receptor Tyrosine Kinase KIT by Stem Cell Factor
Pages 323-334
Satoru Yuzawa, Yarden Opatowsky, Zhongtao Zhang, Valsan Mandiyan, Irit Lax and Joseph Schlessinger
 
 19. A Metabolic Sensor Governing Cell Size in Bacteria
Pages 335-347
Richard B. Weart, Amy H. Lee, An-Chun Chien, Daniel P. Haeusser, Norbert S. Hill and Petra Anne Levin
 
 20. Regulation of Pax3 by Proteasomal Degradation of Monoubiquitinated Protein in Skeletal Muscle Progenitors
Pages 349-362
Stéphane C. Boutet, Marie-Hélène Disatnik, Lauren S. Chan, Kevin Iori and Thomas A. Rando
 
  Resource
 21. A Tunable Genetic Switch Based on RNAi and Repressor Proteins for Regulating Gene Expression in Mammalian Cells
Pages 363-372
Tara L. Deans, Charles R. Cantor and James J. Collins
 
  Matters Arising
 22. Local and cis Effects of the H Element on Expression of Odorant Receptor Genes in Mouse
Pages 373-384
Stefan H. Fuss, Masayo Omura and Peter Mombaerts
 
  Errata
 23. GEFs and GAPs: Critical Elements in the Control of Small G Proteins
Page 385
Johannes L. Bos, Holger Rehmann and Alfred Wittinghofer
 
 24. GAPDH and Autophagy Preserve Survival after Apoptotic Cytochrome c Release in the Absence of Caspase Activation
Page 385
Anna Colell, Jean-Ehrland Ricci, Stephen Tait, Sandra Milasta, Ulrich Maurer, Lisa Bouchier-Hayes, Patrick Fitzgerald, Ana Guio-Carrion, Nigel J. Waterhouse, Cindy Wei Li, Bernard Mari, Pascal Barbry, Donald D. Newmeyer, Helen M. Beere and Douglas R. Green
 
  SnapShot
 25. SnapShot: Hedgehog Signaling Pathway
Pages 386-386.e2
Miao-Hsueh Chen, Christopher W. Wilson and Pao-Tien Chuang
 


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Australian Life Scientist Weekly | That was the week that was ... / Oncaidia goes public with mAb

 

 Friday 27th July 2007

Australian Life Scientist Weekly

That was the week that was ...
Bracks' legacy, AIDS conference, the art of Odile Crick and the science of the Simpsons. More...

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Oncaidia goes public with mAb
SA company offers IPO to further commercialise monoclonal antibody technology. More...

Hydra from out of nowhere
Nine-headed gene in Drosophila thought to have developed from transposon. More...

No wilting in the face of Fusarium
A NSW PhD student is looking at a cotton fungus to understand its interaction with other seedling pathogens. More...

Pigs and pathogens: understanding antibiotic resistance
Research shows that the use of one antibiotic increases resistance but also increases the carriage of resistance genes against other classes of antibiotics. More...

PROFILE: Seek and we shall provide
A Brisbane biomedical scientist has set up an online matching service for researchers. And before you ask, it's aimed at finding professional partners, not romantic ones. More...

TB diagnostic agreement for Proteome Systems
Sputum-based test to be developed by Proteome Systems and BD. More...

Regular boost for high fibre research
CSIRO and universities come together to research new grain varieties with higher fibre. More...

HLA-C may be Achilles heel of HIV
Three SNPs identified in HIV+ people may help delay disease. More...

Microbicide well tolerated, even by men
Starpharma's anti-HIV and herpes microbicide is well tolerated by men, the company told the IAS conference today. More...

Molecular dictator with a conscience
Gene suppressor controls bad cells to allow good cells free rein. More...



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Thursday, July 26, 2007

Keyword News: [stem cell]

Yahoo! Alerts Yahoo! News - My Alerts - Edit Alert
Thursday, July 26, 2007 11:31 PM PDT

Stem cell research plan put on ballot with fanfare
The Star-Ledger Thu, 26 Jul 2007 10:13 PM PDT
Calling stem cell research an engine for medical science and economic development, Gov. Jon Corzine yesterday signed legislation that gives residents the chance to vote on spending $450 million for stem cell research grants.

N.J.: Corzine Signs $450M Stem Cell Bill
AP via Yahoo! Finance Thu, 26 Jul 2007 10:17 AM PDT
New Jersey voters will decide this November whether to approve borrowing $450 million to pay for stem cell research in the state for 10 years under legislation signed Thursday by Gov.

N.J. to vote on stem cell research bond issue
BizJournals Thu, 26 Jul 2007 3:29 PM PDT
Gov. Jon S. Corzine signed into law Thursday the New Jersey Stem Cell Research Bond Act.

Scientists Find Stem Cell Switch In Plants
Science Daily Thu, 26 Jul 2007 12:04 PM PDT
Scientists have discovered how plant stem cells in roots detect soil structure and whether it is favourable for growth. Poor soil structure is a problem in tropical agriculture, where soil becomes compact as it dries out. Scientists have now determined that the plant hormone ethylene regulates cell division in root stem cells.

N.J.: Corzine signs $450M stem cell bill
Boston Globe Thu, 26 Jul 2007 11:30 AM PDT
New Jersey voters will decide this November whether to approve borrowing $450 million to pay for stem cell research in the state for 10 years under legislation signed Thursday by Gov. Jon S. Corzine.

Corzine signs landmark stem cell research bill
WABC-TV New York Thu, 26 Jul 2007 9:42 AM PDT
New Jersey Governor Jon Corzine signed a landmark stem cell research bond act Thursday, which calls for a $450 million bond referendum that will provide financing for stem cell research grants to eligible institutions over a 10 year period.

Corzine signs bill seeking $450M for stem cell research
Asbury Park Press Thu, 26 Jul 2007 9:45 AM PDT
New Jersey voters will decide this November whether to approve borrowing $450 million to pay for stem cell research in the state for 10 years under legislation signed Thursday by Gov. Jon S. Corzine. Corzine signed the bill at the Kessler Rehabilitation Center in West Orange. "Given the lack of leadership from the Bush administration, it is up to the states to do what is necessary to cultivate ...

Corzine to sign bill seeking $450M for stem cell research
Herald News Thu, 26 Jul 2007 6:28 AM PDT
TRENTON -- New Jersey voters will decide this November whether to approve borrowing $450 million to pay for stem cell research in the state for 10 years under legislation scheduled to be signed Thursday by Gov. Jon S. Corzine.

Voters to decide on stem cell funding
Courier-Post Thu, 26 Jul 2007 10:30 AM PDT
WEST ORANGE (AP) -- New Jersey voters will decide this November whether to approve borrowing $450 million to pay for stem cell research in the state for 10 years under legislation signed today by Gov. Jon S. Corzine.

Corzine Asks Voters to Approve $450 Mill for Stem Cell Research
WCBS 880 New York Thu, 26 Jul 2007 10:33 AM PDT
New Jersey voters will decide this November whether to approve borrowing $450 million [Newsday] to pay for stem cell research in the state for 10 years under legislation signed Thursday by Gov. Jon S. Corzine. LISTEN to Reporter Levon Putney with details on the bill.




See more news stories that match my keyword


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Stem Cells Express: Newly Published Papers Online

Stem Cells
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Announcing a 30% increase in the STEM CELLS'
Impact Factor from 6.094 to 7.924!

Stem Cells Online Stem Cells Express Alert

New Stem Cells Stem Cells Express articles have been made available
(for the period 19 Jul 2007 to 26 Jul 2007):


TRANSLATIONAL AND CLINICAL RESEARCH
Injectable Mesenchymal Stem Cell Therapy for Large Cartilage Defects- A Porcine Model
Kevin BL LEE, James HP HUI, Im Chim SONG, Lenny ARDANY, Eng Hin LEE
Stem Cells published 26 July 2007, 10.1634/stemcells.2006-0311
http://stemcells.alphamedpress.org/cgi/content/abstract/2006-0311v1


TISSUE-SPECIFIC STEM CELLS
Chondrogenic Differentiation of Human Bone Marrow Stem Cells in Transwell Cultures: Generation of Scaffold-free Cartilage
Alan D. Murdoch, Lisa M. Grady, Matthew P. Ablett, Theoni Katopodi, Roger S. Meadows, Tim E Hardingham
Stem Cells published 26 July 2007, 10.1634/stemcells.2007-0374 Open Access   OPEN ACCESS ARTICLE
http://stemcells.alphamedpress.org/cgi/content/abstract/2007-0374v1

CD45-positive Blood Cells Give Rise to Uterine Epithelial Cells in Mice
András Bratincsák, Michael J. Brownstein, Riccardo Cassiani-Ingoni, Sandra Pastorino, Ildikó Szalayova, Zsuzsanna E. Tóth, Sharon Key, Krisztián Németh, James Pickel, Éva Mezey
Stem Cells published 26 July 2007, 10.1634/stemcells.2007-0301 Open Access   OPEN ACCESS ARTICLE
http://stemcells.alphamedpress.org/cgi/content/abstract/2007-0301v1

Specification of a Dopaminergic Phenotype from Adult Human Mesenchymal Stem Cells
Katarzyna A. Trzaska, Eldo V. Kuzhikandathil, Pranela Rameshwar
Stem Cells published 26 July 2007, 10.1634/stemcells.2007-0212
http://stemcells.alphamedpress.org/cgi/content/abstract/2007-0212v1

Mesenchymal Stem Cells: their Phenotype, Differentiation Capacity, Immunological Features and Potential for Homing
Giselle Chamberlain, James Fox, Brian Ashton, Jim Middleton
Stem Cells published 26 July 2007, 10.1634/stemcells.2007-0197 Open Access   OPEN ACCESS ARTICLE
http://stemcells.alphamedpress.org/cgi/content/abstract/2007-0197v1

Transcriptional Profiling Of Bipotential Embryonic Liver Cells To Identify Liver Progenitor Cell Surface Markers
SA Ochsner, H Strick-Marchand, Q Qiu, S Venable, A Dean, M Wilde, MC Weiss, GJ Darlington
Stem Cells published 26 July 2007, 10.1634/stemcells.2007-0101 Open Access   OPEN ACCESS ARTICLE
http://stemcells.alphamedpress.org/cgi/content/abstract/2007-0101v2


EMBRYONIC STEM CELLS
The Potential of Stem Cells for Auditory Neuron Generation and Replacement
Bryony Coleman, Michelle G de Silva, Robert K Shepherd
Stem Cells published 26 July 2007, 10.1634/stemcells.2007-0393 Open Access   OPEN ACCESS ARTICLE
http://stemcells.alphamedpress.org/cgi/content/abstract/2007-0393v1

HCN and Cav3 ion Channels Confer Automaticity of Embryonic Stem Cell-derived Cardiomyocytes
Kentoku Yanagi, Makoto Takano, Genta Narazaki, Hideki Uosakii, Takuhiro Hoshino, Takahiro Ishii, Takurou Misaki, Jun K. Yamashita
Stem Cells published 26 July 2007, 10.1634/stemcells.2006-0388
http://stemcells.alphamedpress.org/cgi/content/abstract/2006-0388v1


THE STEM CELL NICHE
The Role of the Donor in the Repair of the Marrow Vascular Niche Following Hematopoietic Stem Cell Transplant
William B. Slayton, Xiao Miao Li, Jason Butler, Steven M. Guthrie, Marda L. Jorgensen, John R. Wingard, Edward W. Scott
Stem Cells published 26 July 2007, 10.1634/stemcells.2007-0158
http://stemcells.alphamedpress.org/cgi/content/abstract/2007-0158v1


LETTER TO THE EDITOR
Beyond the FACS
Raymond Barfield, Xiaohua Chen, Mario Otto, Rupert Handgretinger
Stem Cells published 26 July 2007, 10.1634/stemcells.2007-0519
http://stemcells.alphamedpress.org/cgi/content/abstract/2007-0519v1


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STEM CELLS THE ONCOLOGIST CME ALPHAMED PRESS JOURNALS

Copyright © 2007 by AlphaMed Press.

Wednesday, July 25, 2007

Keyword News: [stem cell]

Yahoo! Alerts Yahoo! News - My Alerts - Edit Alert
Wednesday, July 25, 2007 11:31 PM PDT

Corzine to sign bill seeking $450M for stem cell research
phillyburbs.com Wed, 25 Jul 2007 11:08 PM PDT
TRENTON, N.J. - New Jersey voters will decide this November whether to approve borrowing $450 million to pay for stem cell research in the state for 10 years under legislation scheduled to be signed Thursday by Gov. Jon S. Corzine.

Back fractures common after stem cell transplant, say researchers
The Star Wed, 25 Jul 2007 9:17 PM PDT
New York - More than one third of children and adolescents who undergo allogenic stem cell transplantation have thinning of their bones, and one in five had crushed vertebrae in their backs, researchers have said.

San Francisco hotelier buys stake in Florida stem cell bank
San Francisco Business Times Wed, 25 Jul 2007 12:44 PM PDT
Ki Yong Choi, president and founder of a San Francisco hotel company, has bought 13 percent of the stock of Florida stem cell bank Cryo-Cell International Inc.

International Stem Cell Corporation Issues Letter to Shareholders
Business Wire via Yahoo! Finance Wed, 25 Jul 2007 1:37 PM PDT
OCEANSIDE, Calif.----International Stem Cell Corporation has issued a message from Chairman Kenneth C. Aldrich containing a recap of company milestones achieved since the company completed its Share Exchange Agreement on December 29, 2006.

Stem cell setbacks
Jefferson City News Tribune Wed, 25 Jul 2007 6:52 AM PDT
KANSAS CITY, Mo. (AP) - Eight months ago, Missouri seemed well on its way to becoming a national leader in stem cell research. Voters amended the state's constitution to protect stem cell research - even the controversial form using cells from human embryos.

Eight months after amendment, stem cell movement in Missouri suffers setbacks
Daily Journal Wed, 25 Jul 2007 8:09 AM PDT
KANSAS CITY, Mo. (AP) — Eight months ago, Missouri seemed well on its way to becoming a national leader in stem cell research.

Stem Cell Therapeutics Corp. Announces Initiation of Preclinical Comparator TBI Study
CCNMatthews via Yahoo! Finance Wed, 25 Jul 2007 9:42 AM PDT
CALGARY, ALBERTA-- - Stem Cell Therapeutics Corp. is pleased to announce the initiation of a pre-clinical comparator study designed to characterize the neuroregenerative effects of stem cell proliferative agents plus erythropoietin in an animal model of traumatic brain injury .

ISSCR to focus on scientific, ethical and global challenges in stem cell research
News-Medical-Net Wed, 25 Jul 2007 3:39 AM PDT
The International Society for Stem Cell Research (ISSCR) introduced the 2007-2008 Officers this June at the 5th ISSCR Annual Meeting in Cairns, Australia.

National Stem Cell Holding Announces Patent Application for Newly Discovered Cellular Derived Biomaterials for Tissue ...
PR Newswire via Yahoo! Finance Wed, 25 Jul 2007 5:00 AM PDT
National Stem Cell Holding, Inc. , together with Michael Cohen and Jacob Cohen, today announced the filing of a provisional patent application for a newly discovered group of cellular derived biomaterials that appear to promote tissue repair in a variety of wound care applications.

Cornerstone welcomes Prentice to discuss stem cell research
Murrysville Star Wed, 25 Jul 2007 9:18 AM PDT
David Prentice doesn't want people to think that just because he's speaking at Cornerstone Ministries he's only going to talk about religion. read more »




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Mol. Biol. Cell MBC In Press for 25 Jul 2007

Molecular Biology of the Cell

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Mol. Biol. Cell Online MBC In Press Alert

New Molecular Biology of the Cell MBC In Press articles have been made available
(for the period 18 Jul 2007 to 25 Jul 2007):


Articles
Mrc1 and Tof1 Regulate DNA Replication Forks in Different Ways during Normal S Phase
Ben Hodgson, Arturo Calzada, and Karim Labib
Mol. Biol. Cell published 25 July 2007, 10.1091/mbc.E07-05-0500
http://www.molbiolcell.org/cgi/content/abstract/E07-05-0500v1

Disulfide Bond-mediated Multimerization of Ask1 and Its Reduction by Thioredoxin-1 Regulate H2O2-induced JNK Activation and Apoptosis
Philippe J. Nadeau, Steve J. Charette, Michel B. Toledano, and Jacques Landry
Mol. Biol. Cell published 25 July 2007, 10.1091/mbc.E07-05-0491
http://www.molbiolcell.org/cgi/content/abstract/E07-05-0491v1

Expansion of Chromosome Territories with Chromatin Decompaction In BAF53-depleted Interphase Cells
Kiwon Lee, Mi Jin Kang, Su Jin Kwon, Yunhee Kim Kwon, Ki Woo Kim, Jae-Hwan Lim, and Hyockman Kwon
Mol. Biol. Cell published 25 July 2007, 10.1091/mbc.E07-05-0437
http://www.molbiolcell.org/cgi/content/abstract/E07-05-0437v1

Identification of a Common Subnuclear Localization Signal
Karim Mekhail, Luis Rivero-Lopez, Ahmad Al-Masri, Caroline Brandon, Mireille Khacho, and Stephen Lee
Mol. Biol. Cell published 25 July 2007, 10.1091/mbc.E07-03-0295
http://www.molbiolcell.org/cgi/content/abstract/E07-03-0295v1

Role of the V-ATPase in Regulation of the Vacuolar Fission-Fusion Equilibrium
Tonie L. Baars, Sebastian Petri, Christopher Peters, and Andreas Mayer
Mol. Biol. Cell published 25 July 2007, 10.1091/mbc.E07-03-0205
http://www.molbiolcell.org/cgi/content/abstract/E07-03-0205v1

A Bir1p-Sli15p Kinetochore Passenger Complex Regulates Septin Organization during Anaphase
Scott Thomas and Kenneth B. Kaplan
Mol. Biol. Cell published 25 July 2007, 10.1091/mbc.E07-03-0201
http://www.molbiolcell.org/cgi/content/abstract/E07-03-0201v1

The Abl-related Gene (Arg) Tyrosine Kinase Acts through p190RhoGAP to Inhibit Actomyosin Contractility and Regulate Focal Adhesion Dynamics upon Adhesion to Fibronectin
Justin G. Peacock, Ann L. Miller, William D. Bradley, Olga C. Rodriguez, Donna J. Webb, and Anthony J. Koleske
Mol. Biol. Cell published 25 July 2007, 10.1091/mbc.E07-01-0075
http://www.molbiolcell.org/cgi/content/abstract/E07-01-0075v1

Tumor Cell Apoptosis Polarizes Macrophages—Role of Sphingosine-1-Phosphate
Andreas Weigert, Nico Tzieply, Andreas von Knethen, Axel M. Johann, Helmut Schmidt, Gerd Geisslinger, and Bernhard Brüne
Mol. Biol. Cell published 25 July 2007, 10.1091/mbc.E06-12-1096
http://www.molbiolcell.org/cgi/content/abstract/E06-12-1096v1


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Mol. Biol. Cell Table of Contents for 1 August 2007; Vol. 18, No. 8

Molecular Biology of the Cell

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Mol. Biol. Cell Online Table of Contents Alert

A new issue of Molecular Biology of the Cell is available online:
1 August 2007; Vol. 18, No. 8

The below Table of Contents is available online at: http://www.molbiolcell.org/content/vol18/issue8/?etoc


Articles
Probing the Membrane Environment of the TOR Kinases Reveals Functional Interactions between TORC1, Actin, and Membrane Trafficking in Saccharomyces cerevisiae
Sofia Aronova, Karen Wedaman, Scott Anderson, John Yates, III, and Ted Powers
Mol. Biol. Cell 2007;18 2779-2794
http://www.molbiolcell.org/cgi/content/abstract/18/8/2779

A Developmentally Regulated Chaperone Complex for the Endoplasmic Reticulum of Male Haploid Germ Cells
Marcel van Lith, Anna-Riikka Karala, Dave Bown, John A. Gatehouse, Lloyd W. Ruddock, Philippa T.K. Saunders, and Adam M. Benham
Mol. Biol. Cell 2007;18 2795-2804
http://www.molbiolcell.org/cgi/content/abstract/18/8/2795

Spc24 and Stu2 Promote Spindle Integrity When DNA Replication Is Stalled
Lina Ma, Jennifer McQueen, Lara Cuschieri, Jackie Vogel, and Vivien Measday
Mol. Biol. Cell 2007;18 2805-2816
http://www.molbiolcell.org/cgi/content/abstract/18/8/2805

Bsr, a Nuclear-retained RNA with Monoallelic Expression
Hélène Royo, Eugenia Basyuk, Virginie Marty, Maud Marques, Edouard Bertrand, and Jérôme Cavaillé
Mol. Biol. Cell 2007;18 2817-2827
http://www.molbiolcell.org/cgi/content/abstract/18/8/2817

Myosin Vb Interacts with Rab8a on a Tubular Network Containing EHD1 and EHD3
Joseph T. Roland, Anne K. Kenworthy, Johan Peranen, Steve Caplan, and James R. Goldenring
Mol. Biol. Cell 2007;18 2828-2837
http://www.molbiolcell.org/cgi/content/abstract/18/8/2828

E-Cadherin Inhibits Cell Surface Localization of the Pro-Migratory 5T4 Oncofetal Antigen in Mouse Embryonic Stem Cells
Helen L. Spencer, Angela M. Eastham, Catherine L.R. Merry, Thomas D. Southgate, Flor Perez-Campo, Francesca Soncin, Sarah Ritson, Rolf Kemler, Peter L. Stern, and Christopher M. Ward
Mol. Biol. Cell 2007;18 2838-2851
http://www.molbiolcell.org/cgi/content/abstract/18/8/2838

Interaction of SNAREs with ArfGAPs Precedes Recruitment of Sec18p/NSF
Christina Schindler and Anne Spang
Mol. Biol. Cell 2007;18 2852-2863
http://www.molbiolcell.org/cgi/content/abstract/18/8/2852

Ets-2 Repressor Factor Silences Extrasynaptic Utrophin by N-Box–mediated Repression in Skeletal Muscle
Kelly J. Perkins, Utpal Basu, Murat T. Budak, Caroline Ketterer, Santhosh M. Baby, Olga Lozynska, John A. Lunde, Bernard J. Jasmin, Neal A. Rubinstein, and Tejvir S. Khurana
Mol. Biol. Cell 2007;18 2864-2872
http://www.molbiolcell.org/cgi/content/abstract/18/8/2864

Mesenchymal Stem Cells Use Integrin beta1 Not CXC Chemokine Receptor 4 for Myocardial Migration and Engraftment
James E. Ip, Yaojiong Wu, Jing Huang, Lunan Zhang, Richard E. Pratt, and Victor J. Dzau
Mol. Biol. Cell 2007;18 2873-2882
http://www.molbiolcell.org/cgi/content/abstract/18/8/2873

Quantitative Analysis of Membrane Remodeling at the Phagocytic Cup
Warren L. Lee, David Mason, Alan D. Schreiber, and Sergio Grinstein
Mol. Biol. Cell 2007;18 2883-2892
http://www.molbiolcell.org/cgi/content/abstract/18/8/2883

Interaction of the Endocytic Scaffold Protein Pan1 with the Type I Myosins Contributes to the Late Stages of Endocytosis
Sarah L. Barker, Linda Lee, B. Daniel Pierce, Lymarie Maldonado-Báez, David G. Drubin, and Beverly Wendland
Mol. Biol. Cell 2007;18 2893-2903
http://www.molbiolcell.org/cgi/content/abstract/18/8/2893

Acetylcholinesterase Mobility and Stability at the Neuromuscular Junction of Living Mice
Isabel Martinez-Pena y Valenzuela and Mohammed Akaaboune
Mol. Biol. Cell 2007;18 2904-2911
http://www.molbiolcell.org/cgi/content/abstract/18/8/2904

Nucleoporins Prevent DNA Damage Accumulation by Modulating Ulp1-dependent Sumoylation Processes
Benoit Palancade, Xianpeng Liu, Maria Garcia-Rubio, Andrès Aguilera, Xiaolan Zhao, and Valérie Doye
Mol. Biol. Cell 2007;18 2912-2923
http://www.molbiolcell.org/cgi/content/abstract/18/8/2912

The Nucleolar Net1/Cfi1-related Protein Dnt1 Antagonizes the Septation Initiation Network in Fission Yeast
Quan-Wen Jin, Samriddha Ray, Sung Hugh Choi, and Dannel McCollum
Mol. Biol. Cell 2007;18 2924-2934
http://www.molbiolcell.org/cgi/content/abstract/18/8/2924

Activated Ezrin Promotes Cell Migration through Recruitment of the GEF Dbl to Lipid Rafts and Preferential Downstream Activation of Cdc42
Soren Prag, Maddy Parsons, Melanie D. Keppler, Simon M. Ameer-Beg, Paul Barber, James Hunt, Andrew J. Beavil, Rosy Calvert, Monique Arpin, Borivoj Vojnovic, and Tony Ng
Mol. Biol. Cell 2007;18 2935-2948
http://www.molbiolcell.org/cgi/content/abstract/18/8/2935

The M-Ras-RA-GEF-2-Rap1 Pathway Mediates Tumor Necrosis Factor-{alpha}–dependent Regulation of Integrin Activation in Splenocytes
Yoko Yoshikawa, Takaya Satoh, Takashi Tamura, Ping Wei, Shymaa E. Bilasy, Hironori Edamatsu, Atsu Aiba, Koko Katagiri, Tatsuo Kinashi, Kazuki Nakao, and Tohru Kataoka
Mol. Biol. Cell 2007;18 2949-2959
http://www.molbiolcell.org/cgi/content/abstract/18/8/2949

Plasma Membrane and Nuclear Localization of G Protein–coupled Receptor Kinase 6A
Xiaoshan Jiang, Jeffrey L. Benovic, and Philip B. Wedegaertner
Mol. Biol. Cell 2007;18 2960-2969
http://www.molbiolcell.org/cgi/content/abstract/18/8/2960

The Kinesin-13 Proteins Kif2a, Kif2b, and Kif2c/MCAK Have Distinct Roles during Mitosis in Human Cells
Amity L. Manning, Neil J. Ganem, Samuel F. Bakhoum, Michael Wagenbach, Linda Wordeman, and Duane A. Compton
Mol. Biol. Cell 2007;18 2970-2979
http://www.molbiolcell.org/cgi/content/abstract/18/8/2970

Mechanism Underlying the Iron-dependent Nuclear Export of the Iron-responsive Transcription Factor Aft1p in Saccharomyces cerevisiae
Ryo Ueta, Naoko Fujiwara, Kazuhiro Iwai, and Yuko Yamaguchi-Iwai
Mol. Biol. Cell 2007;18 2980-2990
http://www.molbiolcell.org/cgi/content/abstract/18/8/2980

Canonical Interaction of Cyclin G–associated Kinase with Adaptor Protein 1 Regulates Lysosomal Enzyme Sorting
Satoshi Kametaka, Kengo Moriyama, Patricia V. Burgos, Evan Eisenberg, Lois E. Greene, Rafael Mattera, and Juan S. Bonifacino
Mol. Biol. Cell 2007;18 2991-3001
http://www.molbiolcell.org/cgi/content/abstract/18/8/2991

Identification of Arabidopsis Cyclase-associated Protein 1 as the First Nucleotide Exchange Factor for Plant Actin
Faisal Chaudhry, Christophe Guérin, Matthias von Witsch, Laurent Blanchoin, and Christopher J. Staiger
Mol. Biol. Cell 2007;18 3002-3014
http://www.molbiolcell.org/cgi/content/abstract/18/8/3002

Evidence that Mono-ADP-Ribosylation of CtBP1/BARS Regulates Lipid Storage
René Bartz, Joachim Seemann, John K. Zehmer, Ginette Serrero, Kent D. Chapman, Richard G.W. Anderson, and Pingsheng Liu
Mol. Biol. Cell 2007;18 3015-3025
http://www.molbiolcell.org/cgi/content/abstract/18/8/3015

Phosphatidylinositol-4,5 Bisphosphate Produced by PIP5KI{gamma} Regulates Gelsolin, Actin Assembly, and Adhesion Strength of N-Cadherin Junctions
T. Y. El Sayegh, P. D. Arora, K. Ling, C. Laschinger, P. A. Janmey, R. A. Anderson, and C. A. McCulloch
Mol. Biol. Cell 2007;18 3026-3038
http://www.molbiolcell.org/cgi/content/abstract/18/8/3026

Immobilization of the Type XIV Myosin Complex in Toxoplasma gondii
Terezina M. Johnson, Zenon Rajfur, Ken Jacobson, and Con J. Beckers
Mol. Biol. Cell 2007;18 3039-3046
http://www.molbiolcell.org/cgi/content/abstract/18/8/3039

MRX-dependent DNA Damage Response to Short Telomeres
Valeria Viscardi, Diego Bonetti, Hugo Cartagena-Lirola, Giovanna Lucchini, and Maria Pia Longhese
Mol. Biol. Cell 2007;18 3047-3058
http://www.molbiolcell.org/cgi/content/abstract/18/8/3047

Replication Fork Velocities at Adjacent Replication Origins Are Coordinately Modified during DNA Replication in Human Cells
Chiara Conti, Barbara Saccà, John Herrick, Claude Lalou, Yves Pommier, and Aaron Bensimon
Mol. Biol. Cell 2007;18 3059-3067
http://www.molbiolcell.org/cgi/content/abstract/18/8/3059

Evidence for Coupled Biogenesis of Yeast Gap1 Permease and Sphingolipids: Essential Role in Transport Activity and Normal Control by Ubiquitination
Elsa Lauwers, Guido Grossmann, and Bruno André
Mol. Biol. Cell 2007;18 3068-3080
http://www.molbiolcell.org/cgi/content/abstract/18/8/3068

Naked2 Acts as a Cargo Recognition and Targeting Protein to Ensure Proper Delivery and Fusion of TGF-{alpha}–containing Exocytic Vesicles at the Lower Lateral Membrane of Polarized MDCK Cells
Cunxi Li, Mingming Hao, Zheng Cao, Wei Ding, Ramona Graves-Deal, Jianyong Hu, David W. Piston, and Robert J. Coffey
Mol. Biol. Cell 2007;18 3081-3093
http://www.molbiolcell.org/cgi/content/abstract/18/8/3081

Poleward Tubulin Flux in Spindles: Regulation and Function in Mitotic Cells
Daniel W. Buster, Dong Zhang, and David J. Sharp
Mol. Biol. Cell 2007;18 3094-3104
http://www.molbiolcell.org/cgi/content/abstract/18/8/3094

Parkin-mediated Monoubiquitination of the PDZ Protein PICK1 Regulates the Activity of Acid-sensing Ion Channels
Monica Joch, Ariel R. Ase, Carol X.-Q. Chen, Penny A. MacDonald, Maria Kontogiannea, Amadou T. Corera, Alexis Brice, Philippe Séguéla, and Edward A. Fon
Mol. Biol. Cell 2007;18 3105-3118
http://www.molbiolcell.org/cgi/content/abstract/18/8/3105

Multiple Receptor Interactions Trigger Release of Membrane and Intracellular Calcium Stores Critical for Herpes Simplex Virus Entry
Natalia Cheshenko, Wen Liu, Lisa M. Satlin, and Betsy C. Herold
Mol. Biol. Cell 2007;18 3119-3130
http://www.molbiolcell.org/cgi/content/abstract/18/8/3119

Fast Turnover of L1 Adhesions in Neuronal Growth Cones Involving Both Surface Diffusion and Exo/Endocytosis of L1 Molecules
Caroline Dequidt, Lydia Danglot, Philipp Alberts, Thierry Galli, Daniel Choquet, and Olivier Thoumine
Mol. Biol. Cell 2007;18 3131-3143
http://www.molbiolcell.org/cgi/content/abstract/18/8/3131

Myosin-IIA Heavy-Chain Phosphorylation Regulates the Motility of MDA-MB-231 Carcinoma Cells
Natalya G. Dulyaninova, Reniqua P. House, Venkaiah Betapudi, and Anne R. Bresnick
Mol. Biol. Cell 2007;18 3144-3155
http://www.molbiolcell.org/cgi/content/abstract/18/8/3144

Regulation of RasGRP1 by B Cell Antigen Receptor Requires Cooperativity between Three Domains Controlling Translocation to the Plasma Membrane
Nadine Beaulieu, Bari Zahedi, Rebecca E. Goulding, Ghazaleh Tazmini, Kira V. Anthony, Stephanie L. Omeis, Danielle R. de Jong, and Robert J. Kay
Mol. Biol. Cell 2007;18 3156-3168
http://www.molbiolcell.org/cgi/content/abstract/18/8/3156

Rab11A Controls the Biogenesis of Birbeck Granules by Regulating Langerin Recycling and Stability
Stéphanie Uzan-Gafsou, Huguette Bausinger, Fabienne Proamer, Solange Monier, Dan Lipsker, Jean-Pierre Cazenave, Bruno Goud, Henri de la Salle, Daniel Hanau, and Jean Salamero
Mol. Biol. Cell 2007;18 3169-3179
http://www.molbiolcell.org/cgi/content/abstract/18/8/3169

Two Alternative Mechanisms That Regulate the Presentation of Apoptotic Cell Engulfment Signal in Caenorhabditis elegans
Victor Venegas and Zheng Zhou
Mol. Biol. Cell 2007;18 3180-3192
http://www.molbiolcell.org/cgi/content/abstract/18/8/3180

The Clathrin Adaptor Complex AP-1 Binds HIV-1 and MLV Gag and Facilitates Their Budding
Grégory Camus, Carolina Segura-Morales, Dorothee Molle, Sandra Lopez-Vergès, Christina Begon-Pescia, Chantal Cazevieille, Peter Schu, Edouard Bertrand, Clarisse Berlioz-Torrent, and Eugenia Basyuk
Mol. Biol. Cell 2007;18 3193-3203
http://www.molbiolcell.org/cgi/content/abstract/18/8/3193

Dynein Light Chain Association Sequences Can Facilitate Nuclear Protein Import
Gregory W. Moseley, Daniela Martino Roth, Michelle A. DeJesus, Denisse L. Leyton, Richard P. Filmer, Colin W. Pouton, and David A. Jans
Mol. Biol. Cell 2007;18 3204-3213
http://www.molbiolcell.org/cgi/content/abstract/18/8/3204

E-Cadherin Adhesion Activates c-Src Signaling at Cell–Cell Contacts
Robert W. McLachlan, Astrid Kraemer, Falak M. Helwani, Eva M. Kovacs, and Alpha S. Yap
Mol. Biol. Cell 2007;18 3214-3223
http://www.molbiolcell.org/cgi/content/abstract/18/8/3214


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Stem Cells Future Table of Contents for September 2007; Vol. 25, No. 9

Stem Cells
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Announcing a 30% increase in the STEM CELLS'
Impact Factor from 6.094 to 7.924!

Stem Cells Online -- Future Table of Contents Alert

A new future TOC for Stem Cells is available online for the issue:
September 2007; Vol. 25, No. 9

This Future Table of Contents is available online at: http://stemcells.alphamedpress.org/future/25.9.shtml

These articles have been accepted for this issue. Change is possible before publication.


Letters to the Editor
Stem Cell Therapy for Human Liver Cirrhosis: A Cautious Analysis of the Results
Stefania Lorenzini, Pietro Andreone
Stem Cells 2007 25 (9)

Re: Selection of Stem Cells by Using Antibodies That Target Different CD34 Epitopes Yields Different Patterns of T-Cell Differentiation
D. Robert Sutherland, Michael Keeney
Stem Cells 2007 25 (9)


The Stem Cell Niche
Concise Review: Dendritic Cell Development in the Context of the Spleen Microenvironment
Jonathan K. H. Tan, Helen C. O'Neill
Stem Cells 2007 25 (9)

Novel Extracellular Matrix Structures in the Neural Stem Cell Niche Capture the Neurogenic Factor FGF-2 from the Extracellular Milieu
Aurelien Kerever, Jason Schnack, Dirk Vellinga, Naoki Ichikawa, Chris Moon, Eri Arikawa-Hirasawa, Jimmy T. Efird, Frederic Mercier
Stem Cells 2007 25 (9)


Embryonic Stem Cells
The Future (r)evolution of PGD/HLA Testing: Ethical Reflections
Guido de Wert, Inge Liebaers, Hilde Van de Velde
Stem Cells 2007 25 (9)

High Histone Acetylation and Decreased Polycomb Repressive Complex 2 Member Levels Regulate Gene-Specific Transcriptional Changes During Early Embryonic Stem Cell Differentiation Induced by Retinoic Acid
Elliot R. Lee, Fern E. Murdoch, Michael K. Fritsch
Stem Cells 2007 25 (9)

Tissue Engineering with Chondrogenically-Differentiated Human Embryonic Stem Cells
Eugene J. Koay, Gwen M. B. Hoben, Kyriacos A. Athanasiou
Stem Cells 2007 25 (9)

Differentiation In Vivo of Cardiac Committed Human Embryonic Stem Cells in Post-Myocardial Infarcted Rats
André Tomescot, Julia Leschik, Valérie Bellamy, Gilbert Dubois, Emmanuel Messas, Patrick Bruneval, Michel Desnos, Albert A. Hagège, Michal Amit, Joseph Itskovitz, Philippe Menasché, Michel Pucéat
Stem Cells 2007 25 (9)

Differentiation of Human Embryonic Stem Cells in Serum-Free Medium Reveals Distinct Roles for BMP4, VEGF, SCF, and FGF2 in Hematopoiesis
Marjorie Pick, Lisa Azzola, Anna Mossman, Edouard G. Stanley, Andrew G. Elefanty
Stem Cells 2007 25 (9)

Zfp206 Is a Transcription Factor That Controls Pluripotency of Embryonic Stem Cells
Zheng-Xu Wang, Jacqueline L. L. Kueh, Christina Hui-Leng Teh, Michael Rossbach, Linda Lim, Pin Li, Kee-Yew Wong, Thomas Lufkin, Paul Robson, Lawrence W. Stanton
Stem Cells 2007 25 (9)

Disruption of Apical-Basal Polarity of Human Embryonic Stem Cells Enhances Hematoendothelial Differentiation
Ana Krtolica, Olga Genbacev, Carmen Escobedo, Tamara Zdravkovic, Adam Nordstrom, Diana Vabuena, Aneel Nath, Carlos Simon, Keith Mostov, Susan J. Fisher
Stem Cells 2007 25 (9)

Rotary Suspension Culture Enhances the Efficiency, Yield, and Homogeneity of Embryoid Body Differentiation
Richard L. Carpenedo, Carolyn Y. Sargent, Todd C. McDevitt
Stem Cells 2007 25 (9)

The Effects of Soluble Growth Factors on Embryonic Stem Cell Differentiation Inside of Fibrin Scaffolds
Stephanie M. Willerth, Tracy E. Faxel, David I. Gottlieb, Shelly E. Sakiyama-Elbert
Stem Cells 2007 25 (9)


Stem Cell Genetics and Genomics
Alteration of Marrow Cell Gene Expression, Protein Production, and Engraftment into Lung by Lung-Derived Microvesicles: A Novel Mechanism for Phenotype Modulation
Jason M. Aliotta, Fermin M. Sanchez-Guijo, Gerri J. Dooner, Kevin W. Johnson, Mark S. Dooner, Kenneth A. Greer, Deborah Greer, Jeffrey Pimentel, Luiz M. Kolankiewicz, Napoleon Puente, Sam Faradyan, Paulette Ferland, Elaine L. Bearer, Michael A. Passero, Mehrdad Adedi, Gerald A. Colvin, Peter J. Quesenberry
Stem Cells 2007 25 (9)


Technology Development
Markers and Methods for Cell Sorting of Human Embryonic Stem Cell-Derived Neural Cell Populations
Jan Pruszak, Kai-Christian Sonntag, Moe Hein Aung, Rosario Sanchez-Pernaute, Ole Isacson
Stem Cells 2007 25 (9)


Tissue-Specific Stem Cells
Chemotaxis and Differentiation of Human Adipose Tissue CD34+/CD31- Progenitor Cells: Role of SDF-1 Released by Adipose Tissue Capillary Endothelial Cells
Coralie Sengenès, Alexandra Miranville, Marie Maumus, Sandra de Barros, Rudi Busse, Anne Bouloumié
Stem Cells 2007 25 (9)

New GABAergic Interneurons Supported by Myelin-Specific T Cells Are Formed in Intact Adult Spinal Cord
Ravid Shechter, Yaniv Ziv, Michal Schwartz
Stem Cells 2007 25 (9)

Oxygen Tension Regulates Survival and Fate of Mouse Cortical Precursors at Multiple Levels
Hui-Ling Chen, Francesca Pistollato, Daniel J. Hoeppner, Hsiao-Tzu Ni, Ronald D. G. McKay, David M. Panchision
Stem Cells 2007 25 (9)

A Novel, Immortal, Multipotent Human Neural Stem Cell Line, Generating Functional Neurons and Oligodendrocytes
Lidia De Filippis, Giuseppe Lamorte, Evan Y. Snyder, Antonio Malgaroli, Angelo L. Vescovi
Stem Cells 2007 25 (9)

Malignant Transformation of Multipotent Muscle-Derived Cells by Concurrent Differentiation Signals
Jonathan B. Pollett, Karin A. Corsi, Kurt R. Weiss, Gregory M. Cooper, Denise A. Barry, Burhan Gharaibeh, Johnny Huard
Stem Cells 2007 25 (9)

Timing and Expression Level of PKCε Regulate the Megakaryocytic Differentiation of Human CD34 Cells
Giuliana Gobbi, Prisco Mirandola, Ivonne Sponzilli, Cristina Micheloni, Chiara Malinverno, Lucio Cocco, Marco Vitale
Stem Cells 2007 25 (9)

Identification and Characterization of Vitamin A-Storing Cells in Fetal Liver: Implications for Functional Importance of Hepatic Stellate Cells in Liver Development and Hematopoiesis
Hiroshi Kubota, Hsin-lei Yao, Lola M. Reid
Stem Cells 2007 25 (9)

Clonal Multipotency of Skeletal Muscle-Derived Stem Cells Between Mesodermal and Ectodermal Lineage
Tetsuro Tamaki, Yoshinori Okada, Yoshiyasu Uchiyama, Kayoko Tono, Maki Masuda, Mika Wada, Akio Hoshi, Tetsuya Ishikawa, Akira Akatsukaa
Stem Cells 2007 25 (9)

Characterization, Cryopreservation, and Ablation of Spermatogonial Stem Cells in Adult Rhesus Macaques
Brian P. Hermann, Meena Sukhwani, Chih-Cheng Lin, Yi Sheng, Jamie Tomko, Mario Rodriguez, Jennifer J. Shuttleworth, David McFarland, Robin M. Hobbs, Pier Paolo Pandolfi, Gerald P. Schatten, Kyle E. Orwig
Stem Cells 2007 25 (9)


Translational and Clinical Research
A Tissue Engineering Approach to Progenitor Cell Delivery Results in Significant Cell Engraftment and Improved Myocardial Remodeling
David Simpson, Hong Liu, Tai-Hwang Michael Fan, Robert Nerem, Samuel C. Dudley, Jr.
Stem Cells 2007 25 (9)

Extending JAK2V617F and MPLW515 Mutation Analysis to Single Hematopoietic Colonies and B- and T-Lymphocytes
Animesh Pardanani, Terra L. Lasho, Christy Finke, Ruben A. Mesa, William J. Hogan, Rhett P. Ketterling, D. Gary Gilliland, Ayalew Tefferi
Stem Cells 2007 25 (9)


Translational and Clinical Research: Mesenchymal Stem Cells
Functional Network Analysis on the Transcriptomes of Mesenchymal Stem Cells Derived from Amniotic Fluid, Amniotic Membrane, Cord Blood, and Bone Marrow
Ming-Song Tsai, Shiaw-Min Hwang, Kuang-Den Chen, Yun-Shien Lee, Li-Wen Hsu, Yu-Jen Chang, Chao-Nin Wang, Hsiu-Huei Peng, Yao-Lung Chang, An-Shine Chao, Shuenn-Dyh Chang, Kuan-Der Lee, Tzu-Hao Wang, Hsin-Shih Wang, Yung-Kuei Soong
Stem Cells 2007 25 (9)

Angiogenic Effects of Human Multipotent Stromal Cells (MSCs): Conditioned Medium Activates the PI3K-Akt Pathway in Hypoxic Endothelial Cells to Inhibit Apoptosis, Increase Survival, and Stimulate Angiogenesis
Shih-Chieh Hung, Radhika R. Pochampally, Sy-Chi Chen, Shu-Ching Hsu, Darwin J. Prockop
Stem Cells 2007 25 (9)

Expression of the p16INK4A Gene Is Associated Closely with Senescence of Human Mesenchymal Stem Cells and Potentially Silenced by DNA Methylation During In Vitro Expansion
Kotaro Shibata, Tomoki Aoyama, Yasuko Shima, Kenichi Fukiage, Seiji Otsuka, Moritoshi Furu, Yoshiki Kohno, Kinya Ito, Shunsuke Fujibayashi, Masashi Neo, Tomitaka Nakayama, Takashi Nakamura, Junya Toguchida
Stem Cells 2007 25 (9)


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[StemCells] SC research, eggs, and the poor

Stem cells 'to boost' risky egg trade
Anna Salleh
ABC Science Online
Thursday, 5 July 2007

Poor women are already selling their eggs to pay the rent, new
research shows. Now the added demand for eggs for stem cell research
may place extra pressure on them (Image: iStockphoto)
Demand for eggs for stem cell research will put vulnerable women at
increased pressure to sell their ova to unscrupulous dealers, says an
Australian researcher.

This may not be such an issue for well regulated countries like
Australia, says Associate Professor Catherine Waldby of the
University of Sydney.

But she says it is more likely to affect women in poorly regulated
countries, who already supply eggs to rich nations for IVF programs,
and whose health can suffer as a result.

"There have been various serious medical problems develop in women
involved in selling eggs," says Waldby.

Her findings will be published in the journal New Genetics and
Society.

Waldby, a sociologist of life sciences, says she is concerned about
the effect of stem cell research on an already stretched global
supply of women's eggs.

She is concerned about the implication of obtaining eggs for
therapeutic cloning, which are already in short supply because of the
popularity of IVF.

Therapeutic cloning involves removing the nucleus from an egg and
replacing it with one from a non-reproductive cell, of a patient for
example, to produce an embryo for stem cell research.

She says in countries like Australia, where women are not permitted
to sell their eggs on the open market, the onerous nature of
procuring eggs means that donation is rare and demand is outstripping
supply.

Egg brokers

Waldby says growth in IVF together with cheap air travel have led to
the development of clinics that trade eggs beyond the borders of
national regulation, often selling eggs from poor nations to rich
ones.

"They actually function as brokers between people in countries where
they can't get ova and where it's very regulated, and countries where
it's not," she says.

Waldby says in recent years there has been trafficking of ova from
women in Eastern Europe.

One Romanian clinic has bought eggs from really poor women, she says.

"The clinic was paying them about US$200 a procedure, which is about
two months' salary for these women."

The supply of eggs to create human embryonic stem cells, like this,
is concerning some researchers (Image: M William Lensch, Harvard
Medical School)
One study found some women were repeatedly selling their eggs to pay
for rent, clothes and even cigarettes, says Waldby.

In 2004, UK authorities banned the purchase of eggs from the clinic.
There were concerns the clinic was not telling women about the risks
involved, or looking after them when things went wrong, Waldby says.

Removing eggs involves multiple hormone injections and a surgical
procedure.

Some of the Romanian women developed ovarian hyperstimulation
syndrome, which involves painful abdominal inflammation, possible
renal failure, infertility and cardiovascular problems, says Waldby.

She says there are a lot of countries where this could be a problem.

"Both China and India have large, impoverished populations, extensive
networks of fertility clinics and burgeoning stem cell industries,
setting the scene for exploitative forms of oocyte procurement."

Unlike Australia and the UK, the US allows women to sell their eggs
on the open market. Women with desirable characteristics can get up
to U$100,000 per cycle from IVF clinics for their eggs, says Waldby.

But eggs for research don't command such high premiums because they
depend less on characteristics, she says.

She says at least one US company has been set up specifically to
procure eggs for the biotechnology industry, paying women around
US$4000 per "donation".

This is despite a US National Academy of Sciences recommendation
against the use of purchased eggs for research.

Waldby says there should be international laws that prohibit
scientists from using any cell lines derived from eggs procured in
the absence of ethical guidelines and oversight.

Scientific response

Australian stem cell researcher Professor Bernie Tuch, of the Prince
of Wales Hospital in Sydney, says donating eggs is difficult and
risky and it would be a pity if Waldby's predictions were right.

But he emphasises Australian law prevents trading in human eggs.

"[Waldby's concerns are] of no direct relevance to Australia," he
says.

He also says National Health and Medical Research Council guidelines
require imported embryonic stem cell lines to be developed under the
same conditions that apply in Australia.

http://abc.net.au/science/news/stories/2007/1970360.htm?tech

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StemCells subscribers may also be interested in these sites:

Children's Neurobiological Solutions
http://www.CNSfoundation.org/

Cord Blood Registry
http://www.CordBlood.com/at.cgi?a=150123

The CNS Healing Group
http://groups.yahoo.com/group/CNS_Healing
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[StemCells] Neural SC insight & therapies

Source: Jennifer O'Brien
jobrien@pubaff.ucsf.edu
415-476-2557

05 July 2007

UCSF's Arturo Alvarez-Buylla
Insight into neural stem cells has implications for designing
therapies

Scientists have discovered that adult neural stem cells, which exist
in the brain throughout life, are not a single, homogeneous group.
Instead, they are a diverse group of cells, each capable of giving
rise to specific types of neurons. The finding, the team says,
significantly shifts the perspective on how these cells could be used
to develop cell-based brain therapies.

The results of their study are reported online in "Science Express"
today, July 5, and will be published in an upcoming issue
of "Science."

Adult neural stem cells give rise to the three major types of brain
cells – astrocytes, oligodendrocytes and neurons. Their role in
producing neurons is of particular interest to scientists because
neurons orchestrate brain functions -- thought, feeling and movement.
If scientists could figure out how to create specific types of new
neurons, they potentially could use them to replace damaged cells,
such as the dopamine-producing neurons destroyed in Parkinson's
disease.

In recent years, scientists have determined that adult neural stem
cells are located primarily in two regions of the brain -- the lining
of the brain's fluid-filled cavity, known as the subventricular zone,
and a horseshoe shaped area known as the hippocampus. The laboratory
of the senior author of the current study, UCSF's Arturo Alvarez-
Buylla identified the stem cells in the subventricular zone in 1999
("Cell", June 11, 1999).

While scientists have known that neural stem cells in the developing
brain produce particular types of neurons based on where the stem
cells are located in the embryo, studies carried out in cell culture
have suggested that adult neural stem cells of the fully formed brain
can give rise to many types of brain cells.

In the current study, conducted in mice, the team set out to explore
whether neural stem cells in different locations of the
subventricular zone are all the same. They did so using a method they
developed to follow the fate of early neonatal and adult neural stem
cells in 15 different regions of the subventricular zone. These cells
typically produce young neurons that migrate to the olfactory bulb,
where they mature into several distinct types of interneurons,
neurons that are essential for the sense of smell.

To the team's surprise, the adult neural stem cells in the various
regions of the subventricular zone each gave rise to only very
specific subsets of interneurons. Moreover, the stem cells were not
susceptible to being re-specified. When they were taken out of their
niche and transplanted into another region of the subventricular
zone, they continued to produce the same subset of interneurons.
Similarly, they retained their specialized production of distinct
subtypes of neurons when removed from the animals' brains and exposed
to a cocktail of growth factors in a culture dish.

The findings, says the lead author of the study, Florian T. Merkle a
graduate student in the Alvarez-Buylla lab, suggests that while adult
neural stem cells of the subventricular zone can produce the three
major types of brain cells -- astrocytes, neurons and
oligodendrocytes – when it comes to neurons they seem to be
specified, or programmed, to produce very specific subtypes.

"The data supporting the finding is remarkably clean and was highly
unexpected," says senior author Alvarez-Buylla, UCSF Heather and
Melanie Muss Professor of Neurological Surgery. "We've been studying
this region of the brain for many years and Florian's data has
produced a different scenario, so we have to readjust now."

"We should abandon the idea that these cells are good for making any
kind of neuron. This is just not going to be the case unless we find
ways to reprogram these cells genetically."

The insight, says Merkle, is a key step toward understanding the
molecular mechanisms of neural stem cell potential. "Now you could
compare adult stem cells in different regions at the genetic level.
Since different neural stem cells make different types of neurons,
maybe you could determine which genes are important for making, say,
dopaminergic cells. In theory you could activate these genes in
embryonic stem cells in the culture dish to try to create the desired
type of neuron".

The Alvarez-Buylla lab has identified neural stem cells in the adult
human brain, but it is not known if these cells are heterogeneous. If
human brains show a similar regionalization of stem cells, it might
also be possible, says Alvarez-Buylla, to harvest them from the
brains of patients, expand their numbers in the culture dish to
obtain a particular neuron type, and transplant them back into
patients.

Notably, the distribution of adult neural stem cells throughout the
subventricular zone raises the possibility, he says, that the cells'
activity is regionally modulated in order to regulate the production
of different types of neurons. "This may provide a mechanism for the
brain to dynamically fine tune the olfactory bulb circuitry, raising
a fascinating basic question about neuronal replacement: Why are so
many different types of neurons, with such diverse origins, required
for olfactory function?"

"The implication for cell-based therapies might be that it isn't
sufficient to replace one neuron," he says. "You might have to
replace combinations of different neuronal types when it comes to
reestablishing neural function."

The finding, he says, has not been without its hints. In 1996, the
lab reported (PNAS, Dec. 1996) what he describes as "an amazing
network of pathways" that collect adult neural stem cells from
throughout the wall of the lateral ventricle of the subventricular
zone.

"It's taken us 10 years," he says, "to figure out that these pathways
reflect the transport of young neurons of different types born in
unique locations."

The study was funded by the National Institute of Neurological
Disorders and Stroke, which is part of the National Institutes of
Health, a fellowship from the National Science Foundation and a gift
from Francis and John Bowes.

UCSF is a leading university that advances health worldwide by
conducting advanced biomedical research, educating graduate students
in the life sciences and health professions, and providing complex
patient care.

Alvarez-Buylla lab:
http://neurosurgery.medschool.ucsf.edu/neurosurgery_research/BTRC/alva
rez_buylla_lab.html

UCSF Institute for Regeneration Medicine: http://irm.ucsf.edu

http://pub.ucsf.edu/newsservices/releases/200707052/

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¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯
StemCells subscribers may also be interested in these sites:

Children's Neurobiological Solutions
http://www.CNSfoundation.org/

Cord Blood Registry
http://www.CordBlood.com/at.cgi?a=150123

The CNS Healing Group
http://groups.yahoo.com/group/CNS_Healing
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[StemCells] Facial Reconstruction

A New Path to Facial Reconstruction
07/16/07
USC researcher Songtao Shi and his colleagues experiment with stem
cells that can regenerate bone and skin tissue.
By Ben Creighton

Photo/Ben CreightonIf Songtao Shi's latest discovery ever reaches
Southern California clinics, "Oh, she's had a stem cell job," may one
day replace the ubiquitous "She's had work done" as a tabloid
euphemism for the efforts of the well-heeled to turn back the clock.

Shi, a researcher at USC's Center for Craniofacial Molecular Biology,
and colleagues at dental schools in Korea and China have discovered
that mesenchymal stem cells (MSCs) are capable of regenerating facial
bone and skin tissue in mouse and swine models.

While there remains much to learn, their work published in the April
2007 issue of the journal Stem Cells points to a future in which MSCs
become a plastic surgeon's weapon of choice for everything from
repairing severe facial disfigurement to removing wrinkles.

"It's very exciting," Shi said. "It is fundamentally different from
current techniques. At this point it is just a concept, but in the
future it may change the way we do plastic surgery."

The research employs MSCs derived from two sources. To construct
orofacial bone tissue, Shi and colleagues utilized MSCs extracted
from human bone marrow and transplanted them into the frontal skull.

After eight weeks, a pronounced expansion of the skull was readily
visible. Tests of this new tissue showed it was healthy and fully
integrated into existing bone.

Even more remarkably, the new bone tissue showed evidence of
homeostasis – the process by which red and white blood cells are
created.

"This is very important. This is not an implant. This is an extension
of the body. These cells have the ability to work with and organize
existing cells and tissue," Shi said.

Their second technique relied on MSCs derived from the periodontal
ligament. Introducing these stem cells into the facial wrinkles of a
mouse model, Shi and colleagues found that the periodontal ligament
MSCs eliminated the wrinkles through the production of new collagen
fibers.

Shi hopes to improve his initial results by experimenting with
delivery methods – the stem cells have varying degrees of success
based upon the material used to serve as a scaffold. He also hopes to
investigate the potential of autologous stem cells, those derived
from the animal's own tissue, to improve clinical results.

"There are many potential applications for these techniques," Shi
said. "There is still so much that we don't understand fully. It is
clear that we need more studies to explore new therapies and improve
clinical consequences."

http://www.usc.edu/uscnews/stories/14044.html

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StemCells subscribers may also be interested in these sites:

Children's Neurobiological Solutions
http://www.CNSfoundation.org/

Cord Blood Registry
http://www.CordBlood.com/at.cgi?a=150123

The CNS Healing Group
http://groups.yahoo.com/group/CNS_Healing
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[StemCells] SC aging

Effects Of Aging In Stem Cells
Date: July 24, 2007

Science Daily — There is little disagreement that the body's
maintenance and repair systems deteriorate with age, even as there is
plenty of disagreement as to why. Stem cells combat the aging process
by replenishing old or damaged cells--particularly in the skin, gut,
and blood--with a fresh supply to maintain and repair tissue.

Aging HSCs exhibit a functional decline (yet an increase in cell
number) and display a heightened stress and inflammatory response
along with signs of epigenetic erosion. (Credit: S. M. Chambers, PLoS
Biology, article authors)Ads by Google Advertise on this site

Unfortunately, new evidence published in the open-access journal PLoS
Biology suggests that this regenerative capacity also declines with
age as stem cells acquire functional defects.

Stuart Chambers, Margaret Goodell, and their colleagues investigated
the molecular mechanisms underlying aging of stem cells by looking at
the gene expression profiles of aging hematopoietic stem cells
(HSCs), the precursors of blood cells. They found that genes involved
in the inflammatory and stress response became more active with age,
while genes important for regulating gene expression and genomic
integrity became less active. These results lend strong support to
the notion that HSCs succumb to the wear and tear of aging, just like
other cells, and shed light on the mechanisms of aging.

To study HSCs' regenerative capacity over time, Chambers et al.
isolated HSCs from young (aged 2 months) and old (aged 21 months)
mice and then transplanted either young or old cells into mice whose
bone marrow cells had been destroyed by radiation. The young and old
HSCs gave rise to new marrow cells at roughly the same pace 4 weeks
after transplantation. But at 8 and 16 weeks after transplantation,
the old HSCs' contributions had dropped considerably, suggesting that
aging HSCs lose their repopulating capacity. Yet, because HSCs
increased in number, overall blood production from HSCs remained
stable.

The finding that genes involved in the inflammatory response are
expressed more (called up-regulation) as HSCs age fits with evidence
linking inflammation and aging in the kidney, brain, and arteries. It
may also help explain why HSCs lose function. One of the up-regulated
genes, P-selectin, encodes a cell surface adhesion molecule. Because
transplanted HSCs depend on cell adhesion to colonize bone marrow
properly, the researchers explain, inappropriate up-regulation of
genes encoding P-selectin may interfere with this process.

The markedly reduced expression (or down-regulation) of genes
involved in chromatin remodeling, an "epigenetic" regulator of gene
expression, suggested that transcriptional activity might be
dysregulated across the genome.

Though the dominant model attributes the physical effects of aging to
an accretion of isolated genetic insults, these results link age-
related decline to global mechanisms operating across the genome. In
the researchers' "epigenetic view of aging," chromatin dysregulation
provides a logical explanation for the numerous and diverse age-
related changes observed at the molecular, cellular, and organismal
levels.

Over the normal course of aging, chromatin dysregulation leads to
dysregulation of many genes, which in turn leads to a loss of normal
cellular functions and a loss of growth regulation. These changes
ultimately increase the risk of cancer, which, in many of its forms,
increases dramatically with age. Future studies can investigate how
epigenetic regulation, inflammation, and the stress response interact
to better understand the molecular mechanisms of aging, and why so
many of us face a high risk of cancer in our later years.

Reference: Chambers SM, Shaw CA, Gatza C, Fisk CJ, Donehower LA, et
al. (2007) Aging hematopoietic stem cells decline in function and
exhibit epigenetic dysregulation. PLoS Biol 5(8): e201.
doi:10.1371/journal.pbio.0050201.

Note: This story has been adapted from a news release issued by PLoS
Biology
http://www.sciencedaily.com/releases/2007/07/070724114053.htm

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StemCells subscribers may also be interested in these sites:

Children's Neurobiological Solutions
http://www.CNSfoundation.org/

Cord Blood Registry
http://www.CordBlood.com/at.cgi?a=150123

The CNS Healing Group
http://groups.yahoo.com/group/CNS_Healing
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[StemCells] Monitor bone thinning after (not self) SC transplants

Back fractures common after stem cell transplant
Tue Jul 24, 2007 11:42PM BST
By Martha Kerr

NEW YORK (Reuters Health) - More than one third of children and
adolescents who undergo allogenic stem cell transplantation have
thinning of their bones, and one in five had crushed vertebrae in
their backs, Finnish researchers report.

Allogeneic stem cell transplantation is used to treat leukemia and a
variety of other cancerous and non-cancerous conditions. Allogeneic
means that the cells from a closely matched donor are removed and
implanted in the patient. The goal of therapy is typically to replace
diseased cells of the bone marrow with fully functioning cells from
another person.

Dr. Mervi Taskinen of the University of Helsinki and colleagues
evaluated the bone health of 44 children a few years after they
underwent stem cell transplantation. Study subjects were 18.5 years
of age or younger; at the time of transplantation, they were around
10 years old.

Sixteen patients had evidence of bone thinning, the investigators
report in the journal Cancer. These children were similar to the
other 28 patients in terms of clinical characteristic and laboratory
test results.

Bone thinning "was especially evident at the hip" in the pubertal and
postpubertal children, the investigators say.

Nine patients (20 percent) had vertebral fractures and five patients
(11 percent) had other fractures. Seven of the nine vertebral
fractures caused no symptoms.

The investigators conclude that because of the heightened risk of
bone thinning and vertebral fractures, children undergoing stem cell
transplantation should be carefully monitored after the procedure and
possibly given drugs that help strengthen the bones.

SOURCE: Cancer, July 15, 2007.
http://uk.reuters.com/article/healthNews/idUKLAU48167720070724

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StemCells subscribers may also be interested in these sites:

Children's Neurobiological Solutions
http://www.CNSfoundation.org/

Cord Blood Registry
http://www.CordBlood.com/at.cgi?a=150123

The CNS Healing Group
http://groups.yahoo.com/group/CNS_Healing
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Monday, July 23, 2007

16. CORCELL: www.corcell.com

It seems like every umbilical cord blood bank claims to be the oldest, best, and largest, but at CorCell, we let our experienced team and history speak for themselves. We are a licensed and accredited private cord blood company who has been dedicated to and deeply rooted in stem cell preservation since 1995. Our recognized stem-cell harvesting procedure is preferred by obstetricians for its safe, simple, uncomplicated method. We provide a specialized medical courier to your hospital room to transport your baby's cord blood to our processing facility, in a time and temperature controlled environment. Finally, your baby's cord blood is stored in a recognized, state-of-the-art, AABB accredited cord blood banking facility that has successfully transplanted a significant number of cord blood units to date. Our roots in umbilical stem cell preservation began when we became the first private cord blood company to be licensed in New Jersey for umbilical cord blood collection. Our highly experienced and diverse team is dedicated to providing you with a cord blood stem cell harvesting and preservation process that is preferred by obstetricians and transplant physicians alike. Or Cell, headquartered in Philadelphia, Pennsylvania, began as the first private cord blood company licensed for umbilical cord blood collection, and is now a leader in the processing and storage of umbilical cord blood stem cells for families seeking to safeguard their health for the future. CorCell stores umbilical cord blood stem cells in its private laboratory within the internationally known, AABB accredited banking facility, Bergen Community Blood Services, which has transplanted a significant number of cord blood units to date. Founded in 1995, the Philadelphia-based CorCell was anticipated to be a cord blood bank serving the local area including various parts of Pennsylvania and New Jersey. Over the past several years, however, CorCell has collected umbilical cord blood stem cells from thousands of hospitals in all 50 states and from several other countries, as far away as Australia.

Mailing address
CorCell
1717 Arch Street, Suite 1410
Philadelphia, PA 19103

Contact
Matthew L. Schissler
Phone: 888-882-2673
Fax: 888-588-2673
mls@cordpartners.com

Google Alert - stem cell, embryonic stem cell, adult stem cell

Google News Alert for: stem cell, embryonic stem cell, adult stem cell

CellCyte Executives Highlight Plans for Breakthrough Stem Cell ...
PharmaLive.com (press release) - Newtown,PA,USA
We are focused on basically (adult) stem cell delivery, not embryonic stem cells." Mr. Reys also noted, "CellCyte Genetics' business platform is now well ...
See all stories on this topic

Stem cell specialists face questioning - 2007-07-16
exduco.net - Toscany,Italy
Also on the panel are Alan Coleman, from Embryonic Stem Cell International, Singapore, Chris Mason, from University College, London, and Daniel Brison, ...
See all stories on this topic

House Adopts Smith Amendment That Triples Funding for Life-Saving ...
PharmaLive.com (press release) - Newtown,PA,USA
Unlike embryonic stem cell research -- which to date has yet to produce any cures or treatments -- cord blood and other adult stem cell research already ...
See all stories on this topic

Stem cells and the meaning of life
Waterloo Record - Waterloo,Ontario,Canada
Among religious communities, the question of embryonic stem cell research prompts soul searching about when human life begins. Different faith groups have ...
See all stories on this topic

Japanese Team May Have Found Stem Cell "Holy Grail"
Lifesite - Niagara Falls,NY,USA
By Hilary White MANCHESTER, July 20, 2007 (LifeSiteNews.com) - Since its publication in the journals Nature and Stem Cell on June 7, a report that Japanese ...
See all stories on this topic

LCMS takes stand on stem-cell research
Sioux City Journal - Sioux City,IA,USA
The resolution states opposition to embryonic stem-cell research that destroys human life and has not yet shown success for treatment of diseases in humans. ...
See all stories on this topic

Google Blogs Alert for: stem cell, embryonic stem cell, adult stem cell

Adult Stem Cell Growth Treats Cornea Disorders
By stemceller (posted by Zonk)(pater@slashdot.org)
stemcellar writes with a link to the ScienceDaily site, reporting on a method for adult stem cells to grow cornea stem cells. This use of differentiated stem cells in therapies on specific parts of the body is fairly novel, ...
Slashdot: Generated for crimsun (4771) - http://slashdot.org/

New Method Of Adult Stem Cell Growth Treats Cornea Disorders
A new method of adult stem cell growth has demonstrated its efficacy for its capacity to grow cornea stem cells. The scientists demonstrated applying the growth technique in treating diseases of the cornea, using stem cells, ...
Online Information NEWS & Entertainme... - http://www.apnaavenue.com

Adult Stem Cell Growth Treats Cornea Disorders
By Vash the Stampede
ScienceDaily site, reports on a method for adult stem cells to grow cornea stem cells. This use of differentiated stem cells in therapies on specific parts of the body is fairly novel, the article states, and could have numerous ...
vashNYC: the 60 billion $$ man - http://fanpotai.wordpress.com

Body's repair skills key to stem cell success - Radio Australia
By success
This is also cool stuff An international research team has found the success of adult stem cell therapy depends on the body's ability to repair tissue damaged by ageing. Somthing like that princess Diana Tribute Concert A Huge Success ...
Success Blog - http://success.eblogworldreport.com

New method of adult stem cell therapy to grow cornea stem cells
A new method of adult stem cell growth, designed in the Area of Cellular Therapy of the University Clinic (University of Navarra), has demonstrated its efficacy for its capacity to grow cornea stem cells.
News-Medical News Feed - http://www.news-medical.net

Immune deficiencies
By Dr.Vishaal Bhat(Dr.Vishaal Bhat)
Severe combined immunodeficiency disease (SCID) is a rare disorder characterized by a genetic defect in stem cells that results in the absence of the thymus gland and t and b cells. Affected children are extremely susceptible to ...
MBBS To MD - http://pre-pg.blogspot.com/

US House of Reps. Allocates $15 Million to National Umbilical Cord ...
By scribe
Unlike embryonic stem cell research, which requires the destruction of the human embryo and has yet to produce any cures or treatments, cord blood and other adult stem cell research have resulted in clinical treatments.
Commentary - http://brownpelicanla.com/index.php/all

More adult stem cell advances
By Sister Toldjah
A new method of adult stem cell growth, designed in the Area of Cellular Therapy of the University Clinic (University of Navarra), has demonstrated its efficacy for its capacity to grow cornea stem cells. So Ana Fernández Hortelano, ...
Sister Toldjah - http://sistertoldjah.com

Google Web Alert for: stem cell, embryonic stem cell, adult stem cell

Do No Harm: The Coalition of Americans for Research Ethics
New Research On Adult Cells with Pluripotent Characteristics (President's Council on Bioethics). New Advances in Non-Embryonic Stem Cell Research Since 2004 ...

Slashdot | Adult Stem Cell Growth Treats Cornea Disorders
Adult Stem Cell Growth Treats Cornea Disorders -- article related to Biotech and Science.

Thousands of Adult Stem Cell Deaths Show Urgency of Embryonic Research
Read about the latest medical technology, pharmaceuticals and biotech trends including diets, drugs, genetics, stem cells, medicine, health, ...

MediCult's Novel Media Promotes Adult Stem Cell Growth - Positive ...
MediCult a/s (OSE: MEC), a leader in assisted reproductive technologies (ART), announced that it has successfully demonstrated that its proprietary ...

MIT bioengineer advances survival, promise of adult stem cells ...
MIT researchers have developed a technique to encourage the survival and growth of adult stem cells, a step that could help realize the therapeutic ...

news @ nature.com - Simple switch turns cells embryonic ...
In theory, embryonic stem cells can propagate themselves indefinitely and are ... replacing their genetic material with that from an adult cell and then ...

stemcellresearch.org - Fact Sheet: Adult Stem Cells (72) v ...
The Facts - Prentice, D. "Adult Stem Cells" Appendix K in Monitoring Stem Cell Research: A Report of the President's Council on Bioethics (Washington, ...

Stem cell - Wikipedia, the free encyclopedia
While embryonic stem cell potential remains untested, adult stem cell treatments .... "Induction of pluripotent stem cells from mouse embryonic and adult ...

A new method of adult stem cell growth efficacious in treatment of ...
A new method of adult stem cell growth, designed in the Area of Cellular Therapy of the University Clinic (University of Navarra), has demonstrated its ...

ScienceDaily: A New Method Of Adult Stem Cell Growth Efficacious ...
A new method of adult stem cell growth has demonstrated its efficacy for its capacity to grow cornea stem cells. The scientists demonstrated applying the ...

Can Adult Stem Cells Do It All?: Scientific American
Scientists may have turned mouse skin cells into embryolike stem cells, but prior claims for the power of adult cells have yet to stand the test of time.

What are adult stem cells? [Stem Cell Information]
Some scientists now use the term somatic stem cell instead of adult stem cell. Unlike embryonic stem cells, which are defined by their origin (the inner ...


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Sunday, July 22, 2007

15. CRYOCORD: www.cryocord.com.my

CryoCord Sdn. Bhd. was established early 2002 in answer to the call by the Ministry of Science, Technology and Environment of Malaysia for the research and development of science by local and foreign partnerships in the medical biotechnology sector, where there is a need for companies and institutions in both the public and private sectors to work together, especially in cutting-edge technology. We are a medical biotechnology company specializing in Cord Blood Banking and Stem Cell Research, geared towards establishing itself in South East Asia. In addition, having been conferred MSC Status by the Multimedia Development Corporation, our collection and processing procedures are of the highest standard, and are in line with European standards on Cord Blood Banking. CryoCord Sdn. Bhd. is located within the Multimedia Super Corridor (MSC) at Century Square, Cyberjaya, a high-tech science and research based development center. CryoCord employs very stringent criteria set by the American Association of Blood Banks, and is in strict compliance with European standards on Cord Blood Banking and Stem Cell Research. The CryoCord Processing Laboratory is a state-of-the-art, Class 100 Clean-Room, laboratory and Cryo-Storage facility to ensure the highest quality in the handling of your baby's precious cord blood. The company further supports as well as complements the move by the Malaysian government to develop the biotechnology industry in Malaysia, with a view to establishing Malaysia as one of the leading nations in this industry.

Due to our rapid expansion, we are currently seeking aggressive, highly motivated and professional individuals to join us. Those who are keen to pursue a rewarding and challenging career at CryoCord are invited to submit their resumes to hr@cryocord.com.my


CryoCord Sdn. Bhd.,
29-2, Jalan PJU 1/41,
Block D1, Dataran Prima,
47301 Petaling Jaya, Selangor.
Fax: 603-7880 1919
Email
info@cryocord.com.my

14. BIO-MATRIX SCIENTIFIC GROUP: www.bmsnonline.com

"Adult stem cells obviously have a universal program for division that is common to all the kinds of tissue stem cells, and makes them mutually interchangeable. This was discovered by Alexei Terskikh at Stanford University School of Medicine in California. He was able to prove that adult stem cells of blood-forming tissues, and of the brain, activate the same genes, in order to preserve their status as stem cells." "If these observations are correct and are confirmed by other teams of scientists, science should concentrate on research with adult stem cells and renounce further experiments with the embryonic."

Bio-Matrix Scientific Group Inc. is currently developing products in the following areas:

  • Stem Cell Cryogenics
  • Instrumentation for Stem Cell Research and Tissue
  • Management
  • Non-Invasive Bio-Systems Monitoring and Measuring Devices
  • Niche Medical Device Instrumentation

The Company has recently filed a provisional patent application with the U. S. Patent Office. It anticipates numerous utility patents will result from this filing.

Bio-Matrix Scientific Group Inc.
8885 Rehco Road
San Diego, CA 92122
Telephone: 619.398.3517
FAX: 619.325.0702

Saturday, July 21, 2007

[StemCells] Mesenchymal SCs & lung injury survival

: J Immunol. 2007 Aug 1;179(3):1855-63.
Intrapulmonary delivery of bone marrow-derived mesenchymal stem cells
improves survival and attenuates endotoxin-induced acute lung injury
in mice.Gupta N, Su X, Popov B, Lee JW, Serikov V, Matthay MA.
Cardiovascular Research Institute, University of California, San
Francisco, CA 94143.

Recent in vivo and in vitro work suggests that mesenchymal stem cells
(MSC) have anti-inflammatory properties. In this study, we tested the
effect of administering MSC directly into the airspaces of the lung 4
h after the intrapulmonary administration of Escherichia coli
endotoxin (5 mg/kg). MSC increased survival compared with PBS-treated
control mice at 48 h (80 vs 42%; p < 0.01). There was also a
significant decrease in excess lung water, a measure of pulmonary
edema (145 +/- 50 vs 87 +/- 20 mul; p < 0.01), and bronchoalveolar
lavage protein, a measure of endothelial and alveolar epithelial
permeability (3.1 +/- 0.4 vs 2.2 +/- 0.8 mg/ml; p < 0.01), in the MSC-
treated mice. These protective effects were not replicated by the use
of further controls including fibroblasts and apoptotic MSC. The
beneficial effect of MSC was independent of the ability of the cells
to engraft in the lung and was not related to clearance of the
endotoxin by the MSC. MSC administration mediated a down-regulation
of proinflammatory responses to endotoxin (reducing TNF-alpha and MIP-
2 in the bronchoalveolar lavage and plasma) while increasing the anti-
inflammatory cytokine IL-10. In vitro coculture studies of MSC with
alveolar macrophages provided evidence that the anti-inflammatory
effect was paracrine and was not cell contact dependent. In
conclusion, treatment with intrapulmonary MSC markedly decreases the
severity of endotoxin-induced acute lung injury and improves survival
in mice.

PMID: 17641052 [PubMed - in process]
http://www.ncbi.nlm.nih.gov/sites/entrez?
Db=pubmed&Cmd=ShowDetailView&TermToSearch=17641052&ordinalpos=14&itool
=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

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¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯
StemCells subscribers may also be interested in these sites:

Children's Neurobiological Solutions
http://www.CNSfoundation.org/

Cord Blood Registry
http://www.CordBlood.com/at.cgi?a=150123

The CNS Healing Group
http://groups.yahoo.com/group/CNS_Healing
____________________________________________
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[StemCells] Spinal Cord Injury & blood SC stimulation

The Use of Stem Cells' Hematopoietic Stimulating Factors Therapy
Following Spinal Cord Injury.

Divani AA, Hussain MS, Magal E, Heary RF, Qureshi AI.

Department of Neurology and Neurosciences, UMDNJ, New Jersey Medical
School, Zeenat Qureshi Stroke Research Center, Medical Science
Building, H506, 185 South Orange Ave., Newark, NJ, 07103, USA.

Spinal cord injury (SCI) remains one of the most devestating
conditions in medicine, particularily due to the loss of productive
life years and the high economic burden it places on our society.
There are limited therapeutic options available to reduce the
morbidity and mortality related to SCI. However, recent work with
stem cells in repairing SCI appears to be promising, making this one
of the most exciting frontiers in medicine.A brief review of the
mechanisms of SCI is presented. Stem cells from a variety of sources
have shown effectiveness in improving motor function after SCI in
animals. The pre-clinical use of stem cells in SCI and methods of
delivery are discussed. The potential use of granulocyte-colony
stimulating factor (G-CSF) to increase the number of stem cells
engrafting at the site of injury in order to improve neurological and
motor function recovery following SCI is introduced.G-CSF, through
stimulation of lymphohemopoietic stem cells in peripheral blood, can
potentially cause repopulation of the SCI region with neural
progenitor cells. This allows for improved functional outcomes. More
pre-clinical and translational research exploring this possibility is
required.

Ann Biomed Eng. 2007 Jul 20;

PMID: 17641973 [PubMed - as supplied by publisher]

http://www.ncbi.nlm.nih.gov/sites/entrez

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StemCells subscribers may also be interested in these sites:

Children's Neurobiological Solutions
http://www.CNSfoundation.org/

Cord Blood Registry
http://www.CordBlood.com/at.cgi?a=150123

The CNS Healing Group
http://groups.yahoo.com/group/CNS_Healing
____________________________________________
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Friday, July 20, 2007

[StemCells] Cornea Stem Cells Grown

Stem cell growth efficacious in treatment of disorders of the cornea

A new method of adult stem cell growth, designed in the Area of
Cellular Therapy of the University Clinic (University of Navarra),
has demonstrated its efficacy for its capacity to grow cornea stem
cells.

So Ana Fernández Hortelano, ophthalmologist at the Hospital
demonstrated on applying the growth technique in treating diseases of
the cornea, using stem cells, in 70 test animals (rabbits). The aim
of the procedure was to regain the da maged epithelium and thus
restore transparency to the cornea.

In concrete, the thesis defended by doctor Fernández Hortelano at the
Faculty of Medicine of the University of Navarra, proves the
therapeutic efficiency in using corneal stem cells in patients with
pathologies of the cornea, such as caustications or ocular herpes, by
using stem cells from a healthy contralateral eye. The technique is
being currently applied to patients with satisfactory results.

The research has two essential parts. On the one hand, it describes
the design of a new method of cell growth and, on the other, explains
the clinical application of the procedure.Growth in two stages

The research undertaken by the ophthalmologist has shown that, from a
small biopsy sample, the new growth technique enables the growth of
the number of stem cells thus obtained to the point of obtaining
sufficient for the treatment to be effective. The cell sample is
taken from the limb of the healthy eye – the ocular structure
responsible for the transparency of the cornea.

The importance of this growth method lies in the fact that it enables
the characterisation of the cells obtained, i.e. determining the
quantity and viability of the units to be used.

The method developed combines culture on a plastic chip with that of
an amniotic membrane one. The novelty of the technique focuses on the
first stage – where the plastic chip is used. The fragment of tissue
obtained from the healthy eye divides into smaller fractions which
are grown on the chip. Thus a greater number of halos of stem cells
are obtained (as many as the fragments of tissue). A sample of the
cells obtained are then sent the Anatomic Pathology laboratory where
the viability and quality of the cell units are verified.

The cells are transferred to the amniotic membrane growth culture,
one that is highly suitable when dealing with stem cells that are to
be transplanted for ocular regeneration treatment.

Once in the amniotic membrane, the stem cells expand in a homogeneous
manner, enabling a better cell identification in order to select the
most suitable units for the treatment. This method permits finding
out with precision the cell population that we are implanting in the
eye and to verify, thereby, both the quality and quantity of the
cells transplanted.Clínical application

The second part of the research involved the clinical application of
the adult stem cells transplant in rabbits, which previously have had
an epithelial corneal lesion induced, causing loss of corneal
transparency. This is a pathology that does not respond to a corneal
transplant nor to other conventional treatment.

The procedure used by Dr Fernández Hortelano involved obtaining this
type of cell – corneal stem cells – by means of a biopsy of cells
from a healthy eye of the rabbit. This is a small sample of cells - 3
by 4 mm - and so the contrateral eye is not in danger. A tiny number
of cells thus being involved, it is necessary to grow the samples in
order to obtain greater numbers of cells, an expansion achieved by
transferring the culture to the amniotic membrane.

The adult stem cells obtained are implanted in the da maged eye and
the limb is regenerated, this leading to the recovery of the corneal
epithelium and, thereby, the transparency of the cornea. The results
to date achieved amongst the group of rabbits, with induced limbic
insufficiency and which then had a transplant of adult stem cells,
showed recovery of the corneal epithelium in 60% of the treated
animals. The corneal epithelium is the layer that is da maged with
limbic insufficiency, a problem which, in the long term, results in
opacity of the cornea.

http://www.spiritindia.com/health-care-news-articles-11563.html

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StemCells subscribers may also be interested in these sites:

Children's Neurobiological Solutions
http://www.CNSfoundation.org/

Cord Blood Registry
http://www.CordBlood.com/at.cgi?a=150123

The CNS Healing Group
http://groups.yahoo.com/group/CNS_Healing
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[StemCells] Genzyme's SC mobilizer , Mozobil, phase 3 trials successful

Genzyme Announces Phase 3 Trial of Mozobil in non-Hodgkin's Lymphoma
Meets Primary Endpoint

July 19, 2007: 08:59 AM EST

CAMBRIDGE, Mass., July 19 /PRNewswire-FirstCall/ -- Genzyme Corp.
today announced that it has successfully completed its phase 3 trial
of Mozobil(TM) (plerixafor) in non-Hodgkin's lymphoma (NHL), and that
the trial has robustly met its primary and secondary endpoints.

The randomized, double-blind, placebo-controlled trial included 298
patients who were undergoing a hematopoietic stem cell transplant
(HSCT) for NHL at medical centers in the United States and Canada. It
examined the effectiveness of Mozobil in increasing the number of
hematopoietic stem cells collected for a transplant. The study
compared the hematopoietic stem cell yield from patients treated with
Mozobil in combination with G-CSF to patients treated with G-CSF in
combination with placebo. G-CSF is the standard of care for
stimulating the mobilization of stem cells from the bone marrow;
Mozobil is designed to allow for the more rapid and effective release
of those stem cells from the marrow into the circulating blood for
collection by apheresis.

In the primary efficacy endpoint, 59 percent of patients treated with
a combination of Mozobil and G-CSF achieved the target threshold for
collection of at least 5 million CD34+cells/kg from the peripheral
blood with four or fewer days of apheresis sessions, compared with 20
percent of patients in the G-CSF/placebo group. The three-fold
increase was highly statistically significant in favor of the Mozobil-
treated patients (p<0.0001). The 40 percent absolute difference
between the two treatment groups was nearly double the target that
Genzyme prospectively defined in the protocol for the study, which
was reviewed by FDA as part of the Special Protocol Assessment
process.

In the secondary efficacy endpoint, nearly 87 percent of patients
treated with Mozobil and G-CSF achieved the minimum level of stem
cells generally associated with a successful transplant (2 million
CD34+cells/kg) in four or fewer days of apheresis sessions, compared
with approximately 47 percent in the placebo arm. This result was
also highly statistically significant in favor of the Mozobil-treated
patients (p<0.0001).

The other secondary efficacy endpoints were supportive of these
findings, including analysis of the number of days needed to reach
target ranges for stem cell mobilization, the success of engraftment,
the number of days needed to engraft, and the durability of the
engraftment for the first 100 days.

Mozobil was well tolerated in the trial, with the most common adverse
events being mild gastrointestinal effects and redness at the site of
injection. There were two related serious adverse events seen in the
Mozobil plus G-CSF arm, and one in the G-CSF plus placebo arm.

"These are very impressive results with far-reaching clinical
importance for patients undergoing a stem cell transplant for
lymphoma," said Principal Investigator John F. DiPersio, M.D., Ph.D.,
professor, Washington University, St. Louis. "Current literature
suggests that increasing the number of stem cells in circulation and
the number collected at the time of apheresis may improve the
outcomes of patients undergoing a stem cell transplant, reduce the
costs associated with stem cell collection and, more importantly,
broaden the pool of patients for whom transplantation is an option."

Based on these results Genzyme expects to file for US and European
approval in lymphoma in the first half of 2008. In addition, Genzyme
is completing a second phase 3 trial of Mozobil in multiple myeloma,
and results are expected in the coming weeks.

About Mozobil

Mozobil, a novel small molecule CXCR4 chemokine antagonist, has been
shown in multiple earlier studies to rapidly and effectively increase
the number of stem cells in circulation in the blood. Once
circulating in the blood, stem cells can be collected for use in a
stem cell transplant. Mozobil has been granted special protocol
assessment and orphan drug status in the United States and European
Union and the pivotal trials have undergone Special Protocol
Assessment by the FDA and Protocol Assistance by the EMEA. Genzyme
intends to commercialize Mozobil through its existing global
transplant business to hematologists and hematopoietic stem cell
transplant centers in more than 50 countries throughout the world.
Genzyme has been developing Mozobil since its acquisition of AnorMED,
Inc. in 2006.

Approximately 55,000 stem cell transplants are performed each year
for multiple myeloma, Hodgkin's and non-Hodgkin's lymphoma, and other
conditions in markets where Genzyme has a commercial infrastructure,
including the United States, Europe, Latin America and the Asian
Pacific countries.

About Genzyme

One of the world's leading biotechnology companies, Genzyme is
dedicated to making a major positive impact on the lives of people
with serious diseases. Since 1981, the company has grown from a small
start-up to a diversified enterprise with more than 9,000 employees
in locations spanning the globe and 2006 revenues of $3.2 billion.
Genzyme has been selected by FORTUNE as one of the "100 Best
Companies to Work for" in the United States.

With many established products and services helping patients in
nearly 90 countries, Genzyme is a leader in the effort to develop and
apply the most advanced technologies in the life sciences. The
company's products and services are focused on rare inherited
disorders, kidney disease, orthopaedics, cancer, transplant, and
diagnostic testing. Genzyme's commitment to innovation continues
today with a substantial development program focused on these fields,
as well as immune disease, infectious disease, and other areas of
unmet medical need.

This press release contains forward-looking statements, including the
statements regarding: the anticipated clinical importance for
patients undergoing stem cell transplants, the anticipated
improvements with respect to patient outcomes, the potential increase
in the number of patients for whom transplantation may become
available, the timing expectations associated with the multiple
myeloma phase 3 clinical trial results, Genzyme's anticipated timing
associated with regulatory submissions for US and European regulatory
approvals for Mozobil and Genzyme's global commercialization plans
for Mozobil and its ability to leverage its existing commercial
infrastructure. These statements are subject to risks and
uncertainties that could cause actual results to differ materially
from those projected in these forward-looking statements. These risks
and uncertainties include, among others, the possibility of
unfavorable multiple myeloma phase 3 clinical trial results, the
failure of Mozobil to receive regulatory approvals for the label or
on the schedule expected, the uncertainties of launching a new
product on a global scale following receipt of applicable regulatory
approvals due to misestimates of the time and resources required to
do so, or for other reasons, the failure of Mozobil to receive
favorable pricing or reimbursement; the possible inaccuracies of
Genzyme's analysis with respect to markets and number of potential
patients for Mozobil; and the risks and uncertainties described in
reports filed by Genzyme with the Securities and Exchange Commission
under the Securities Exchange Act of 1934, as amended, including
without limitation the information under the heading "Factors
Affecting Future Operating Results" in the Management's Discussion
and Analysis of Financial Condition and Results of Operations section
of the Genzyme Quarterly Report on Form 10-Q for the quarter ending
March 31, 2007. Genzyme cautions investors not to place substantial
reliance on the forward-looking statements contained in this press
release. These statements speak only as of the date of this press
release, and Genzyme undertakes no obligation to update or revise the
statements.

Genzyme(R) is a registered trademark and Mozobil TM is a trademark of
Genzyme Corporation. All rights reserved.

Genzyme's press releases and other company information are available
at www.genzyme.com and by calling Genzyme's investor information line
at 1-800-905-4369 within the United States or 1-678-999-4572 outside
the United States.

Media Contact: Investor Contact:
Dan Quinn Sally Curley
(617) 768-6849 (617) 768-6140

http://money.cnn.com/news/newsfeeds/articles/prnewswire/NETH0281907200
7-1.htm

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¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯
StemCells subscribers may also be interested in these sites:

Children's Neurobiological Solutions
http://www.CNSfoundation.org/

Cord Blood Registry
http://www.CordBlood.com/at.cgi?a=150123

The CNS Healing Group
http://groups.yahoo.com/group/CNS_Healing
____________________________________________
«¤»¥«¤»§«¤»¥«¤»§«¤»¥«¤»«¤»¥«¤»§«¤»¥«¤»§«¤»¥«
¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯¯
Recent Activity
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[StemCells] Marrow for Autoimmune (MS, etc.)

MS Society Announces 2.4 Million Dollars To Continue Ottawa Bone
Marrow Stem Cell Transplant Trial
Main Category: Multiple Sclerosis News
Article Date: 19 Jul 2007 - 1:00 PDT

The Multiple Sclerosis Society of Canada announced a 2.4 million
dollars grant to continue a closely-watched clinical trial involving
an experimental bone marrow stem cell transplant therapy. The trial
is being conducted by a team of Canadian MS specialists led by Dr.
Mark Freedman and Dr. Harry Atkins in Ottawa.

"The aim of the study was to see if this treatment protocol could
halt deterioration in a group of MS patients with rapidly progressive
disease," says Jon Temme, vice president of client services and
research for the MS Society. "Currently, the majority of the 18
patients have stabilized or improved, and the focus of this second
phase of the trial will be to determine if this stabilization can be
maintained."

Multiple sclerosis is a chronic, often disabling disease of the brain
and spinal cord. Between 55,000 and 75,000 Canadians have MS making
it the most common neurological disease of young adults in Canada.
Most people with MS are diagnosed between the ages of 15 and 40.

MS symptoms are unpredictable and vary greatly from person to person
but can include: double or blurred vision; extreme fatigue; loss of
balance; stiffness of muscles; speech problems; bladder and bowel
problems; and even partial or complete paralysis.

"The idea behind this clinical trial is to replace the diseased
immune system with a new one derived from the patient's own bone
marrow stem cells," explains Dr. Harry Atkins, a scientist at the
Ottawa Health Research Institute, bone marrow transplant specialist
at the Ottawa Hospital, and assistant professor at the University of
Ottawa. "First we purify and freeze the patient's stem cells, then we
use strong chemotherapy to destroy their existing immune system, and
then we transplant the purified stem cells back into the patient. It
takes time, but eventually these stem cells will form a completely
new immune system - one that does not attack the brain and spinal
cord - we hope."

A similar procedure has been used to treat certain types of blood
cancer for more than 25 years, but applying the procedure to treat
autoimmune diseases such as MS is novel.

"We hoped that this therapy would halt or slow the progression of MS,
and in the patients examined so far, it seems to have worked," says
Dr. Mark Freedman, a senior scientist at the Ottawa Health Research
Institute, director of the Ottawa Hospital MS Clinic, and professor
at the University of Ottawa. "In addition, some patients have
experienced substantial improvements in their ability to see and
walk. This was unexpected, and it suggests the exciting possibility
that the th